Volume 16, Issue 3

Harikumar Selvaraj, Santhini Gopalakrishnan

pp. 836–842 · DOI: 10.5530/ijpi.20260035 · 2026

Sirtuin 1 (SIRT1) is a metabolic regulator implicated in insulin signaling, inflammation, and mitochondrial function. Several SIRT1 gene polymorphisms have been linked to Type 2 Diabetes Mellitus (T2DM) and its complicat…

Kaniga Pandi, Binoy Varghese Cheriyan, Dharshan Murali, Nesayan Boobalan, Jeevitha Harikrishnan, Deepshikaa Kannan, Lini Priyadharshini Christopher Jebaraj, Shamyuktha Munuswamy, Shagul Hameed Manaksha, Sriharan Sekar, Vimal Palaniraja, Naresh Sivagnanam, Revathy Kumar

pp. 843–858 · DOI: 10.5530/ijpi.20260055 · 2026

Bone-drug interactions represent a critical yet often under recognized domain within clinical pharmacology due to their long-term implications on skeletal integrity. The human skeletal system relies on a tightly regulate…

Teng Ma

pp. 859–862 · DOI: 10.5530/ijpi.20260112 · 2026

Schizophrenia is a chronic and severe psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive deficits, imposing profound burdens on patients, families, and healthcare systems worldwide.…

Isha Anil Mirzapure, Manish Deshmukh, Manjusha Bhange, Yash Manoj Salve, Mayur Rajeshwar Dandekar

pp. 863–879 · DOI: 10.5530/ijpi.20260500 · 2026

The delayed access to innovative medicinal products such as orphan drugs and biologics and mRNA vaccines and advanced therapy medicinal products ATMPs occurs in numerous developing nations because of disjointed regulator…

Vishal Kulkarni, R T Sai Kumari, Sanjunath Satteppa Muchandi, Sanatkumar Bharamu Nyamagoud, H M Nanjappaiah, Vishwanath Jagadevappa Hooli, Sangamesh Sharanbasappa Tadkal, Prasad Nijaguni Bali

pp. 880–884 · DOI: 10.5530/ijpi.20261067 · 2026

Parkinson's Disease (PD) is a common neurodegenerative disorder. It is defined by a progressive loss of dopamine neurons in the substantia nigra pars compacta and neurodegeneration, which eventually results in a decrease…

Durga Pani Kumar Anumolu, Bugga Veena, Syed Sara Afreen, Jahnavi Bandla, KNV. Chenchu Lakshmi, Veera Shakar Pulusu

pp. 885–891 · DOI: 10.5530/ijpi.20260116 · 2026

Background In vitro assays play a crucial part in evaluating the metabolic fate of drug candidates and understanding the activity of drug-metabolizing enzymes. Materials and Methods Model systems including Hepatocytes, S…

Pragati Jain, Abhinav Srivastava, Anurag Verma, Urvashi Saxena

pp. 892–909 · DOI: 10.5530/ijpi.20260186 · 2026

The stepwise overview of the regulatory approval pathway for new drugs in India, focusing on requirements and key forms mandated by the NDCT Rules, 2019. It explains how new drugs are legally defined and categorized, set…

Mohammed Tarique, Abdulmajeed Abdulghani Abdulmajeed Sindi, Nawal Helmi, Qamre Alam

pp. 910–918 · DOI: 10.5530/ijpi.20260225 · 2026

Breast Cancer (BC) is the leading cause of mortality in the majority of women around the globe. It stands as one of the most common types of cancer after non-melanoma skin cancer. Contemporary oncology distinguishes BC u…

Jitendra Pratap Singh, Deepak Singh, Gaurav Tiwari

pp. 953–960 · DOI: 10.5530/ijpi.20260053 · 2026

Background It is very hard to measure Methotrexate (MTX), $(CUR), and Etodolac (ETO) all at the same time because they have very different chemical and physical qualities and might work well together in inflammation and …

Chandana, Mohammad Ali, D.R Bharathi

pp. 978–983 · DOI: 10.5530/ijpi.20260012 · 2026

Background Diabetes-induced oxidative stress adversely impacts ovarian granulosa cells, affecting fertility in women. This study explores the protective effects of captopril and spironolactone, two RAAS inhibitors, again…

Nasrin E. Khalifa, Ghaida Fayez, Jomana Altamimi, Hanan Alanazi, Maha Soud, Ryam Alanazi, Haya Alshammari

pp. 990–996 · DOI: 10.5530/ijpi.20260537 · 2026

Background Although herbal remedies are commonly utilized among cardiovascular patients in Saudi Arabia, regional data from Hail remains limited. Objective: The present research investigated prevalence, patterns, motivat…

Kirti Ganeshprasad Sahu, Deepak Shamrao Khobragade, Ram Dnyaneshwar Bawankar

pp. 997–1004 · DOI: 10.5530/ijpi.20260346 · 2026

Background Endophytes are non-pathogenic microorganisms that reside within plant tissues without causing symptoms of infection. Mimosa pudica Linn., a sensitive plant with a long history of traditional medicinal use for …

Muhammad Abid Mustafa, Asad Majeed Khan, Ayesha Atif, Fatima Wajid, Nasir Ali, Khuram Ashfaq, Muhammad Abuzar Ghaffari, Nabeela Jabeen, Rabbia Nasir, Faiza Arshad, Laiba Kaleem

pp. 1005–1017 · DOI: 10.5530/ijpi.20260145 · 2026

Background Transdermal drug delivery systems provide a sophisticated and patient-compliant strategy for arthritis management by maintaining consistent plasma concentrations, reducing dosing frequency, and minimizing gast…

Saritha Medapati, Vandana Rani Malakar, Naga Mallikarjun Pyda, Prasanthi Pakalapati, Sheik Jakir Hussain Mustaq, Seetha Devi Alla

pp. 1018–1024 · DOI: 10.5530/ijpi.20260098 · 2026

Background To formulate and assess floating bilayer tablets of Tizanidine Hydrochloride (TZN) intended to extend gastric retention and for sustained release of the drug. Materials and Methods Six bilayered floating table…

Amal Satheesa Chandran, Ashok Patil, Sanjiv Kumar, Padmaveer Puthiyidam Sreenikakumar, Sreeja Kaimal Vijayakumara Kaimal

pp. 1025–1031 · DOI: 10.5530/ijpi.20260117 · 2026

Background Amalaka Rasayana Churna (ARC) is a polyherbal Ayurvedic formulation consisting of Amalaki (Emblica officinalis Gaertn.), Pippali (Piper longum L.), Ghrita (ghee), Madhu (honey), and Sarkara (sugar) traditional…

Gulam Mohammed Husain, Divya Kodavath, Tasleem Ahmad, Younis Iftikhar Munshi, Mohd Urooj

pp. 1032–1038 · DOI: 10.5530/ijpi.20260047 · 2026

Background Kushta is an ultra-fine powdered product in Unani medicine, created through calcination of animal, metals and mineral substances. Kushta-e-Faulad is a traditional compound Unani formulation to manage Su’al-Qin…

Lakshmipriya Bachina, Kanagala Anusha, Niveditha Pallerla

pp. 1039–1045 · DOI: 10.5530/ijpi.20260086 · 2026

Aim/Background Generative Artificial Intelligence (Generative AI or Gen AI) is a subset of Artificial Intelligence that produces multimedia content, including text, images, stories, videos, music, and other digital artif…

Veena Kalyani Sunkanna, Vedamurthy Joshi, Anoop Manjunath

pp. 1046–1055 · DOI: 10.5530/ijpi.20260088 · 2026

Aim/Background Parkinson’s Disease (PD) is second most common chronic ongoing neurodegenerative disease recorded in ageing population, which is primarily treated with medications that either replace dopamine or mimic its…

Neha Shyam Bora, Mayur Shivaji Bhosale, Amol Sambhaji Balsane, Vikrant Murlidhar Dhamak, Rohit Jaysing Bhor, Sagar Magar Dattatraya, Sanket KeshavTambe

pp. 1056–1063 · DOI: 10.5530/ijpi.20260097 · 2026

Background Cyclooxygenase-2 (COX-2) is a key enzyme involved in inflammation, making it an important target for anti-inflammatory drug discovery. Derivatives of benzoimidazole are well recognized for diverse pharmacologi…

Tiyagura Nagaraja Kumari, Bachunaga Kishore Babu, Daniel Pilli, Repalle Giddaiah, K. Sowjanya

pp. 1064–1077 · DOI: 10.5530/ijpi.20260100 · 2026

Background Network pharmacology provides a comprehensive systems-level framework for the domains of drug discovery, precision medicine, and the repurposing of therapeutics. Despite the rapid advancement of technology, th…