Volume 16, Issue 2

Original Article

1. Article

   In vitro Insights: Investigating the Cytotoxic Properties of Curcuma caesia Roxb. and Aloe vera in situ Gel

   Ankita Bohra, Thirupambaram Nataraja Sundaram Uma Maheswari

   pp. 1–8 · DOI: 10.5530/ijpi.20260087 · 2026

   Background Chewing areca nuts is associated with the development of Oral Submucous Fibrosis (OSF), an oral disorder with malignant potential. While OSF has only recently begun to appear in Europe and North America, it re…

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2. Article

   Screening of Phytochemicals as PIP5K1α Protein Inhibitors for Breast Cancer Treatment: A Bio Computational Study

   Ahmed Mulfi Alharbi

   pp. 585–589 · DOI: 10.5530/ijpi.20260049 · 2026

   Aim/Background Breast Cancer (BC) is one of the most common cancers affecting women globally. PIP5K1α catalyzes PtdIns-4,5-P2 (PIP2), a Precursor to PtdIns-3,4,5-P3 (PIP3), required for AKT activation. Overexpression of …

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3. Article

   Drug Utilization Evaluation of Proton Pump Inhibitors in the General Medicine Ward of a Tertiary Care Hospital

   Shivalingayya Gadagayya Hiremath, Umesh Chaudhary, Giridhar Koratagere Sreekanth, Sai Keerthana Ravishankar, Manikanta Devaraj, Shailesh Yadav

   pp. 590–598 · DOI: 10.5530/ijpi.20260331 · 2026

   Background Proton Pump Inhibitors (PPIs) are the most effective agents for managing acid related disorders. However, Inappropriate Prescribing of PPIs is becoming an issue of concern. Purpose To review proton pump inhibi…

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4. Article

   Formulation, Optimization, and Evaluation of Lornoxicam Medicated Chewing Gum Using Ion Exchange Resin Taste Masking

   Kinjal Shah, Hemani Joshi, Shailvi Shah, Tejal Mehta

   pp. 596–578 · DOI: 10.5530/ijpi.20260096 · 2026

   Background This study aimed to develop and evaluate a taste-masked Medicated Chewing Gum (MCG) of Lornoxicam (LXM) using Kyron T-114, a weak cation exchange resin, to improve palatability and patient compliance. LXM, a p…

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5. Article

   Drug Utilization Evaluation of Antibiotics in an Indian Hospital Setting: A Prospective Observational Study

   Sanatkumar Bharamu Nyamagoud, Laxmi Bhimappa Totar, Hema Yadav, S M Shoaib Ahamed, Khandke Shruti Achyut, Vaishanavi Vanasakrithmath, R Ranjani, Tanushree R Bantanur, Chandan Ashok Naik, Shivani Mathapati, Spoorthi G Lakkannavar, K H Karthik

   pp. 599–605 · DOI: 10.5530/ijpi.20260421 · 2026

   Background Rational drug use is essential to improving healthcare outcomes and minimizing risks such as antimicrobial resistance. This study evaluates prescription patterns in the General Medicine Department of an Indian…

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6. Article

   Preparative Separation, Identification and Characterization of N-Acylated Impurity in Ciprofloxacin Eye Drops Formulations Using 1D and 2D NMR Techniques

   Bhupinder Kumar, Raju Mudhulkar, Sreedhar Gundekari, Surbhi Tiwari, Dama Venugopala Rao, Lakki Reddy Prakash, Ramakrishna Yadav Belly, Sandeep Kumar

   pp. 606–617 · DOI: 10.5530/ijpi.20260460 · 2026

   Background Packaging, storage and transportation of under varying climatic conditions have the quality concern in the drug products. This study followed the observed unknown impurity of ciprofloxacin eye drop. Materials …

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7. Article

   In silico Analysis of 6, 6’-Dihydroxythiobinupharidine on the Enzymes Involved in Cognitive Impairment

   Pranav Nayak, Mohammad Ali, DR Bharathi

   pp. 618–624 · DOI: 10.5530/ijpi.20260468 · 2026

   Background Cognitive impairment signifies a reduction in mental abilities resulting from different factors like Alzheimer's disease leading to a diminished quality of life. Detecting it early and implementing interventio…

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8. Article

   DAVID and KEGG-Based Functional Enrichment Analysis of Breast Cancer Transcriptome: Mapping ECM Remodeling and Cell Division Pathways

   Akram Ahmed Aloqbi

   pp. 625–637 · DOI: 10.5530/ijpi.20260075 · 2026

   Background Breast cancer, affecting roughly 2.3 million people each year, stands as a major global health concern due to its molecular complexity across subtypes such as luminal, HER2-enriched, and triple-negative. These…

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9. Article

   Neuroprotection and Oxidative Stress Reduction by Bacillus coagulans: Anin vitro Comparison with Escitalopram

   Usha Dhoddametikurke Siddappa, Mandara Mathighatta Suresh, Mohd Sharique Katchhi, Babiker Bashir Haroun Baraka, Shilpashree Bettadapura Muralidhar, Chinthana Handankere Basavaraju, Chakure Aditya, Jyothi Murthy, Rajamma Abburu Jayaramu

   pp. 638–644 · 2026

   Background: Neurodegenerative and psychiatric disorders are often linked to oxidative stress and mitochondrial dysfunction, necessitating novel therapeutic strategies. Bacillus coagulans, a probiotic known for its role i…

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10. Article

    Detection of Various Poison in Biological Sample Using High Performance Thin Layer Chromatography

    Jayasutha Jayram, Jerad Suresh Ayyadurai, Jagadeesan Subramanian, Lokesh kumar Dhavanam Ramesh Babu, Mohanraj vadivelu, Naveen Raj Ravi Kumar, Silviya Jenifer John Bosco, Pravin Kumar Muthukumaresan, Sathya Samikkannu, Yashwan Babu, Raman Lakshmisundaram, Ramakrishnan Trichur Venkatakrishnan

    pp. 645–653 · DOI: 10.5530/ijpi.20260608 · 2026

    Background Poisoning is a major public health issue in many countries, particularly in India, where exposures to pesticides, household agents, drugs, industrial chemicals, and animal toxins are common. Contributing facto…

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11. Article

    Computational Tool and Molecular Properties to Identify the Molecular Targets of Novel Benzimidazole Derivatives as Potential COX Inhibitors via in silico Approaches

    Vinod Rajendra Tawate, Sanket Keshav Tambe, Shubham Popatrao Mankar, Nilima Mahesh Wani, Sneha Abhishek Vikhe, Manisha Dhondiram Sonawane, Rohit Jaysing Bhor

    pp. 654–666 · DOI: 10.5530/ijpi.20260528 · 2026

    Background Using a variety of computational techniques, in silico studies allow for forecasting structural changes and how they would impact the pharmacological properties as well as the efficiency of these modifications…

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12. Article

    Evaluating the Safety and Efficacy of Hydroxyurea in Adult Sickle Cell Disease: A Prospective Observational Study

    Rajesh Hadia, Kular Simran, Param Bhatt, Priyanka Yadav, Sarvajeet Khare, Cyril Sajan, Varunsingh Saggu, Hemraj Singh Rajput, Jitendra Lakhani

    pp. 667–678 · DOI: 10.5530/ijpi.20260007 · 2026

    Background Sickle Cell Disease (SCD) is characterized by recurrent hospitalizations and painful Vaso-Occlusive Crises (VOCs). VOCs are prevalent and often necessitate hospital admissions. Aim and Objectives This study ai…

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13. Article

    Formulation and Evaluation of Antiacne Emulgel Using Aloe vera

    Kamaladevi Kshatriya, Shivanand Swamy Panchayya Hiremath, Jathin Subhash Kalal, Fatima Sanjeri Dasankoppa, M Mahesh Yadav, Pradeep Bhimagouda Mirje, Jayatheertha Lokapur, Arpitha Lokapur, Rohan Ravsaheb Latwade, Pranav Babasaheb Patil

    pp. 679–686 · DOI: 10.5530/ijpi.20260041 · 2026

    Introduction Emulgels are emerging as efficient topical drug delivery systems due to their dual-release mechanism, combining the benefits of both emulsions and gels. This system facilitates the enhanced delivery of hydro…

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14. Article

    Phyllanthin Topical Formulation with Penetration Enhancers Alleviates Imiquimod-Induced Psoriasis in Rats via Modulation of Inflammatory Biomarkers and Oxidative Stress Markers

    Papiya Bigoniya, Vanita Chature

    pp. 687–701 · DOI: 10.5530/ijpi.20260554 · 2026

    Background Psoriasis is a persistent inflammatory skin condition marked by abnormal epidermal proliferation and excessive keratinization, impairing effective drug absorption. To overcome these barriers, topical formulati…

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15. Article

    In vitro Antioxidant and Antiglycemic Effects of Malus domestica, Musa acuminata Colla, Mangifera indica, Citrus reticulata and Punica granatum Fruits Peel Extracts

    C Reddy Prasad, Bibi Umeza, M Yuvaraj, A K Afzal Khan, Swapna R Nayaka, Thirunavukkarasu Jayaraman

    pp. 702–707 · DOI: 10.5530/ijpi.20260059 · 2026

    Objectives This study aims to evaluate the anti-glycemic and antioxidant qualities of Malus domestica fruit (apple), Musa acuminata Colla fruit (banana), Mangifera indica fruit (mango), Citrus reticulata fruit (orange), …

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16. Article

    Cardiovascular Disease Risk Factors in Diabetics with and without Metabolic Syndrome in NAFLD Patients

    Mohammad Shane Alam, Yahia Mjery, Kamal Ahmad, Yahia Ali Kaabi, Mohammad Suhail Akhter, Fakhra Jabeen, Jobran Mohammad Moshi, Alaa Ali Alhazmi, Md Intekhabul Haque, Saif Elden Babikar Abdalla, Mathkour Hazem

    pp. 708–714 · DOI: 10.5530/ijpi.20260150 · 2026

    Background Globally, Non-Alcoholic Fatty Liver Diseases (NAFLD) is considered as the frequent chronic liver diseases strongly linked with metabolic dysfunction and cardiovascular risk specifically in Type 2 Diabetes Mell…

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17. Article

    Investigating the Prevalence of Pathogens and Drug Sensitivity in Catheter-Associated Urinary Tract Infections among ICU Patients: Insights from a Hospital-Based Cross-Sectional Study

    Navpreet Singh Babbar, Rabinoor Singh, Arti Saini, Inderjeet Verma, Tarun Singh

    pp. 715–721 · DOI: 10.5530/ijpi.20260403 · 2026

    Background Catheter-Associated Urinary Tract Infections (CAUTIs) pose a major concern in Intensive Care Units (ICUs) due to their association with prolonged catheterization and severe underlying conditions. These infecti…

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18. Article

    Formulation and Development of Euphorbia hirta Phytosomes Capsule for Treatment of Urinary Tract Infection

    Supriya Waghmare, Shreeya Belwalkar, Amir Shaikh, Sidhhi Bansode, Akancha Kumari, Pooja Deshmane, Archana Nagare, Mohini Bhawane, Nitin Salunkhe

    pp. 728–736 · DOI: 10.5530/ijpi.20260344 · 2026

    Background Euphorbia hirta, also known as the "asthma plant" or "snake weed," belongs to the Euphorbiaceae family. However, its oral use as a drug has certain limitations, such as low bioavailability and high first-pass …

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19. Article

    Green Metric Based Thin-Layer Chromatography Coupled with Mass Spectrometry to Identify Degradation Products of Lumateperone in Bulk and Formulation

    Minal Ghante, Jyoti Tangde, Vidhya Bhusari, Arpana Patil, Payal Parmar

    pp. 744–753 · DOI: 10.5530/ijpi.20260273 · 2026

    Objectives The goal of current work was to develop a new, simple, reliable and sensitive High-Performance Thin-Layer Chromatography (HPTLC) method for the estimation of lumateperone. This study also includes the identifi…

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20. Article

    Evaluation of Potentially Inappropriate Medication Use in Elderly Patients Using Beers Criteria in Community Pharmacy

    G Guru., Jagadish kakadiya, S. Lavanya

    pp. 754–761 · DOI: 10.5530/ijpi.20260524 · 2026

    Background With a mature worldwide population, the safety and appropriateness of the medications prescribed to older adults become ever more important. This study expected to determine the occurrence and categorization o…

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