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International Journal of Pharmaceutical InvestigationNOW IN
Article

Dissolution enhancement of glimepiride using modified gum karaya as a carrier

Manju Nagpal1★, Rampal Rajera2, Kalpana Nagpal2, Pankaj Rakha3, SK Singh2, DN Mishra2★ Corresponding author

  1. 1College of Pharmacy, Chitkara University, Rajpura, Patiala, Punjab, INDIA.
  2. 2Department of Pharmaceutical Sciences, G.J. University of Science and Technology, Hisar, INDIA.
  3. 3Rajendra Institute of Technology and Sciences, Sirsa, Haryana, INDIA.

CORRESPONDENCE

Manju Nagpal

College of Pharmacy, Chitkara University, Rajpura, Patiala, Punjab, INDIA.

nagpalmanju@ymail.com

Volume 2, Issue 1 · pp. 42–47 · PUBLISHED · DOI: 10.4103/2230-973X.96925

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ABSTRACT

Objective: The aim of present investigation is to enhancein vitro dissolution of poorly soluble drug glimepiride by preparing solid dispersions using modified gum karaya. Materials and Methods: Solid dispersions of drug were prepared by solvent evaporation method using modified gum karaya as carrier. Four batches of solid dispersion (SD1, SD4, SD9, and SD14) and physical mixture (PM1, PM4, PM9, and PM14) were prepared and characterized by differential scanning colorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, powder X-Ray diffraction (X-RD), and scanning electron microscopy (SEM) studies. Equilibrium solubility studies were carried out in shaker incubator for 24 h and in vitro drug release was determined using USP Dissolution Apparatus-II. Results: Maximum solubility and in vitro dissolution were observed with Batch SD4. No significant enhancement of dissolution characteristics were observed in the corresponding physical mixture PM4. Low viscosity with comparable swelling characteristics as compared to GK of modified form of gum karaya may lead to improvement in dissolution behavior of solid dispersion batches. Also, the conversion of crystalline form of drug to amorphous form may be a responsible factor, which was further confirmed by DSC, FTIR studies, and X-RD studies. SEM photographs of batch SD4 revealed porous nature of particle surface. Conclusion:Modified forms of natural carriers prove beneficial in dissolution enhancement of poorly soluble drugs and exhibited a great potential in novel drug delivery systems.

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    Nagpal, M., Rajera, R., Nagpal, K., Rakha, P., Singh, S., & Mishra, D. (). Dissolution enhancement of glimepiride using modified gum karaya as a carrier. International Journal of Pharmaceutical Investigation, 2(1), 42–47. https://doi.org/10.4103/2230-973X.96925