Volume 2, Issue 1

· pp. 1–51 · 8 articles

In this issue

Forum Article
Thank you authors and reviewers
Javed Ali
pp. 1 · DOI: 10.4103/2230-973X.96919 · Published
First and foremost I express heartfelt appreciation to all authors and reviewers of the first year ofInternational Journal of Pharmaceutical Investigation (IJPI) on behalf of the entire editorial board and the publisher.…

Review
Drug delivery systems: An updated review
Gaurav Tiwari, Ruchi Tiwari, Birendra Sriwastawa, L Bhati, S Pandey, P Pandey, Saurabh K Bannerjee
pp. 2–11 · DOI: 10.4103/2230-973X.96920 · Published
Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are…
Review
Improvement in solubility of poor water-soluble drugs by solid dispersion
Swati Sareen, George Mathew, Lincy Joseph
pp. 12–17 · DOI: 10.4103/2230-973X.96921 · Published
This article is intended to combine recent literature on solid dispersion technology for solubility enhancement with special emphasis on mechanism responsible for the same by solid dispersion, various preparation methods…

Article
The effect of water on the solid state characteristics of pharmaceutical excipients: Molecular mechanisms, measurement techniques, and quality aspects of final dosage form
Gergely Szakonyi, Romána Zelkó
pp. 18–25 · DOI: 10.4103/2230-973X.96922 · Published
In this paper we give an overview about the interaction of water molecules with pharmaceutical excipients. Most of these excipients are amorphous or partially amorphous polymers and their characteristics are very sensiti…

Article
Design, evaluation and in vitro - in vivo correlation of glibenclamide buccoadhesive films
R Indira Prasanna, K Uma Sankari
pp. 26–33 · DOI: 10.4103/2230-973X.96923 · Published
Background: Glibenclamide (G) is a popular anti-diabetic drug, belonging to the class of sulfonylurea. The drug is widely used for treating type II diabetes but it undergoes first-pass effect. A novel aspiration in treat…
Article
Formulation and optimization of mucoadhesive bilayer buccal tablets of atenolol using simplex design method
SB Shirsand, Sarasija Suresh, GG Keshavshetti, PV Swamy, P Vijay Prakash Reddy
pp. 34–41 · DOI: 10.4103/2230-973X.96924 · Published
Introduction: In the present study, mucoadhesive buccal bilayer tablets of atenolol were fabricated with the objective of avoiding first pass metabolism and to improve its bioavailability with reduction in dosing frequen…

Article
Dissolution enhancement of glimepiride using modified gum karaya as a carrier
Manju Nagpal, Rampal Rajera, Kalpana Nagpal, Pankaj Rakha, SK Singh, DN Mishra
pp. 42–47 · DOI: 10.4103/2230-973X.96925 · Published
Objective: The aim of present investigation is to enhancein vitro dissolution of poorly soluble drug glimepiride by preparing solid dispersions using modified gum karaya. Materials and Methods: Solid dispersions of drug …
Article
In vitro evaluation of Moringa oleifera gum for colon- specific drug delivery
Anil Kumar Singhal, Edwin E Jarald, Ahmad Showkat, Anwar Daud
pp. 48–51 · DOI: 10.4103/2230-973X.96926 · Published
Background: Moringa gum obtained from stem of the plant Moringa oleifera Lam. belonging to family Moringaceae. Number of naturally occurring polysaccharides obtained from plant (guar gum, inulin), animal (chitosan, chond…