Fabrication and optimization of camptothecin loaded Eudragit S 100 nanoparticles by Taguchi L4 orthogonal array design

ABSTRACT

Introduction:The objective of this investigation was to design and optimize the experimental conditions for the fabrication of camptothecin (CPT) loaded Eudragit S 100. Nanoparticles, and to understand the effect of various process parameters on the average particles size, particle size uniformity and surface area of the prepared polymeric nanoparticles using Taguchi design. Materials and Methods:CPT loaded Eudragit S 100 nanoparticles were prepared by nanoprecipitation method and characterized by particles size analyzer. Taguchi orthogonal array design was implemented to study the infl uence of seven independent variables on three dependent variables. Eight experimental trials involving seven independent variables at higher and lower levels were generated by design expert. Results:Factorial design result has shown that (a) except, β-cyclodextrin concentration all other parameters do not signifi cantly infl uenced the average particle size (R1); (b) except, sonication duration and aqueous phase volume, all other process parameters signifi cantly infl uence the particle size uniformity; (c) all the process parameters does not signifi cantly infl uence the surface area. Conclusion: The R1, particle size uniformity and surface area of the prepared drug-loaded polymeric nanoparticles were found to be 120 nm, 0.237 and 55.7 m2/g and the results were good correlated with the data generated by the Taguchi design method.

KEYWORDS

• Camptothecin
• Eudragit S 100
• nanoprecipitation
• polymeric nanoparticles
• Taguchi orthogonal array design

Showing references and in-text citations exactly as published.

• DOI10.4103/2230-973X.160852Copy

RELATED ARTICLES

Matched on section and article type within this issue of IJPI.

• Article · VOLUME 5, ISSUE 3Synthesis and self-assembly of biodegradable polyethylene glycol-poly (lactic acid) diblock copolymers as polymersomes for preparation of sustained release system of doxorubicinMona Alibolandi, Fatemeh Sadeghi, Seyed Hossein Sazmand, Seyed Mohammad Shahrokhi, Mahmoud Seifi, Farzin Hadizadeh · pp. 134–141Original Research ArticleSame type: Article
• Article · VOLUME 5, ISSUE 3Enhancement of ketorolac tromethamine permeability through rat skin using penetration enhancers: An ex-vivo studyPawan Kumar, Shailendra Kumar Singh, Dina Nath Mishra, Priti Girotra · pp. 142–146Original Research ArticleSame type: Article
• Article · VOLUME 5, ISSUE 3Dual agents loaded polymeric nanoparticle: Effect of process variablesDeepak Sharma, Gilphy Philip, Reema Gabrani, Javed Ali, Shweta Dang · pp. 155–160Original Research ArticleSame type: Article
• Article · VOLUME 5, ISSUE 3Microspheres and tablet in capsule system: A novel chronotherapeutic system of ketorolac tromethamine for site and time specifi c deliveryPriya Shahi, Neeraj Kumari, Kamla Pathak · pp. 161–170Original Research ArticleSame type: Article