Volume 5, Issue 4

Ningning Yang

pp. 179–181 · DOI: 10.4103/2230-973X.167646

MicroRNAs (miRNAs) are small endogenous noncoding RNAs that direct posttranscriptional regulation of gene expression. Mature miRNAs function as components of RNA-induced silencing complex and interact directly with the 3…

Saba Khan, Sanjula Baboota, Javed Ali, Sana Khan, Ramandeep Singh Narang, Jasjeet Kaur Narang

pp. 182–191 · DOI: 10.4103/2230-973X.167661

Nowadays exploration of novel lipid-based formulations is akin to a magnet for researchers worldwide for improving the in vivo performance of highly lipophilic drugs. Over the last few years, new compositions of lipids h…

Ansh Dev Ravi, D Sadhna, D Nagpaal, L Chawla

pp. 192–199 · DOI: 10.4103/2230-973X.167662

Needle free injection technology (NFIT)is an extremely broad concept which include a wide range of drug delivery systems that drive drugs through the skin using any of the forces as Lorentz, Shock waves, pressure by gas …

Kannissery Pramod, Salim Shanavas, Shahid H. Ansari, Javed Ali

pp. 200–204 · DOI: 10.4103/2230-973X.167669

Introduction:Development of novel biomaterials for drug delivery which forms a part of the so called novel drug delivery systems has always been exhilarating. Mechanical evaluation of polymer based topical gels, which wo…

Ramprasad Chintalapudi, T. E. G. K. Murthy, K. Rajya Lakshmi, G. Ganesh Manohar

pp. 205–213 · DOI: 10.4103/2230-973X.167676

Background: The aim of the present study was to formulate and optimize the self-emulsifying drug delivery systems (SEDDS) of nevirapine (NVP) by use of 22 factorial designs to enhance the oral absorption of NVP by improv…

Prabhakara Prabhu, Akhilesh Dubey, Vinod Parth, Vivek Ghate

pp. 214–225 · DOI: 10.4103/2230-973X.167684

Background:Hydrogel is a cross-linked network of polymers. Water penetrates these network causing swelling and giving the hydrogel a soft and rubbery consistency and there by maintaining the integrity of the membrane. Du…

Jyotsana R Madan, Bhushan R Adokar, Kamal Dua

pp. 226–233 · DOI: 10.4103/2230-973X.167686

Aim and Background:Pregabalin (PRG), an analog of gamma-aminobutyric acid, reduces the release of many neurotransmitters, including glutamate, and noradrenaline. It is used for the treatment of epilepsy; simple and compl…

Ankita Gupta, Gaurav Tiwari, Ruchi Tiwari, Rishabh Srivastava

pp. 234–246 · DOI: 10.4103/2230-973X.167688

Introduction:The work was aimed to develop an enteric-coated hydroxypropyl methylcellulose (HPMC) capsules (ECHC) plugged with 5-fluorouracil (5-FU)-loaded microsponges in combination with calcium pectinate beads. Materi…

Mihir K. Raval, Jaydeep M. Patel, Rajesh K. Parikh, Navin R. Sheth

pp. 247–258 · DOI: 10.4103/2230-973X.167689

Purpose:The aim of the present work was to improve rate of dissolution and processing parameters of BCS class II drug, chlorzoxazone using cogrinding technique in the presence of different excipients as a carrier. Materi…

Arezoo Amanatfard, Payam Khazaeli, Abbas Pardakhty, Moslem Lari Najafi, Amin Mohammadi

pp. 259–265 · DOI: 10.4103/2230-973X.167691

Introduction: The insect repellent compounds are used to protect humans, animals and plants against insect bites. Aromatic amides have insect repellent effects. N,N-diethyl-meta-toluamide (DEET) (C12H17NO) is one of the …

Nidhi Garg, Parijat Pandey, Deepak Kaushik, Harish Dureja

pp. 266–274 · DOI: 10.4103/2230-973X.167692

Introduction:The objective of the present investigation was to develop a novel multifunctional directly compressible co-processed excipient consisting of dibasic calcium phosphate anhydrous, polyethylene glycol 4000 (PEG…

Avinash Bhaskar Gangurde, Ajay Kumar Sav, Sharadchandra Dagadu Javeer, Kailas K Moravkar, Jaywant N Pawar, Purnima D Amin

pp. 275–283 · DOI: 10.4103/2230-973X.167696

Introduction: Choline bitartrate (CBT) is a vital nutrient for fetal brain development and memory function. It is hygroscopic in nature which is associated with stability related problem during storage such as developmen…