Formulation, optimization, and evaluation of self-emulsifying drug delivery systems of nevirapine
Ramprasad Chintalapudi1★, T. E. G. K. Murthy1, K. Rajya Lakshmi1, G. Ganesh Manohar2★ Corresponding author
- 1Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, INDIA.
- 2Department of Pharmaceutical Analysis, Nirmala College of Pharmacy, Mangalagiri, Guntur, Andhra Pradesh, INDIA.
CORRESPONDENCE
Ramprasad Chintalapudi
Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, INDIA.
Volume 5, Issue 4 · pp. 205–213 · PUBLISHED · DOI: 10.4103/2230-973X.167676
ABSTRACT
Background: The aim of the present study was to formulate and optimize the self-emulsifying drug delivery systems (SEDDS) of nevirapine (NVP) by use of 22 factorial designs to enhance the oral absorption of NVP by improving its solubility, dissolution rate, and diffusion profile. SEDDS are the isotropic mixtures of oil, surfactant, co-surfactant and drug that form oil in water microemulsion when introduced into the aqueous phase under gentle agitation. Materials and Methods: Solubility of NVP in different oils, surfactants, and co-surfactants was determined for the screening of excipients. Pseudoternary phase diagrams were constructed by the aqueous titration method, and formulations were developed based on the optimum excipient combinations with the help of data obtained through the maximum micro emulsion region containing combinations of oil, surfactant, and co-surfactant. The formulations of SEDDS were optimized by 22 factorial designs. Results:The optimum formulation of SEDDS contains 32.5% oleic acid, 44.16% tween 20, and 11.9% polyethylene glycol 600 as oil, surfactant, and co-surfactant respectively. The SEDDS was evaluated for the following drug content, self-emulsification time, rheological properties, zeta potential, in vitro diffusion studies, thermodynamic stability studies, and in vitro dissolution studies. An increase in dissolution was achieved by SEDDS compared to pure form of NVP. Conclusion: Overall, this study suggests that the dissolution and oral bioavailability of NVP could be improved by SEDDS technology.
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Chintalapudi, R., Murthy, T. E. G. K., Lakshmi, K. R., & Manohar, G. G. (). Formulation, optimization, and evaluation of self-emulsifying drug delivery systems of nevirapine. International Journal of Pharmaceutical Investigation, 5(4), 205–213. https://doi.org/10.4103/2230-973X.167676