International Journal of Pharmaceutical Investigation
Volume 5, Issue 4
· pp. 179–283 · 12 articles
- Volume
- 5
- Issue
- 4
- Published
- Pages
- 179–283
- Articles
- 12
- Sections
- 3
- ISSN
- Print - 2230-973X, Online -2230-9713
- Journal
- IJPI
In this issue
Editorial
- Forum Article
An overview of viral and nonviral delivery systems for microRNA
Ningning Yang
pp. 179–181 · DOI: 10.4103/2230-973X.167646 · Published
MicroRNAs (miRNAs) are small endogenous noncoding RNAs that direct posttranscriptional regulation of gene expression. Mature miRNAs function as components of RNA-induced silencing complex and interact directly with the 3…
Review Article
- Review
Nanostructured lipid carriers: An emerging platform for improving oral bioavailability of lipophilic drugs
Saba Khan, Sanjula Baboota, Javed Ali, Sana Khan, Ramandeep Singh Narang, Jasjeet Kaur Narang
pp. 182–191 · DOI: 10.4103/2230-973X.167661 · Published
Nowadays exploration of novel lipid-based formulations is akin to a magnet for researchers worldwide for improving the in vivo performance of highly lipophilic drugs. Over the last few years, new compositions of lipids h…
- Review
Needle free injection technology: A complete insight
Ansh Dev Ravi, D Sadhna, D Nagpaal, L Chawla
pp. 192–199 · DOI: 10.4103/2230-973X.167662 · Published
Needle free injection technology (NFIT)is an extremely broad concept which include a wide range of drug delivery systems that drive drugs through the skin using any of the forces as Lorentz, Shock waves, pressure by gas …
Original Research Article
- Article
Eugenol significantly affects the flow of its nanodroplet gel
Kannissery Pramod, Salim Shanavas, Shahid H. Ansari, Javed Ali
pp. 200–204 · DOI: 10.4103/2230-973X.167669 · Published
Introduction:Development of novel biomaterials for drug delivery which forms a part of the so called novel drug delivery systems has always been exhilarating. Mechanical evaluation of polymer based topical gels, which wo…
- Article
Formulation, optimization, and evaluation of self-emulsifying drug delivery systems of nevirapine
Ramprasad Chintalapudi, T. E. G. K. Murthy, K. Rajya Lakshmi, G. Ganesh Manohar
pp. 205–213 · DOI: 10.4103/2230-973X.167676 · Published
Background: The aim of the present study was to formulate and optimize the self-emulsifying drug delivery systems (SEDDS) of nevirapine (NVP) by use of 22 factorial designs to enhance the oral absorption of NVP by improv…
- Article
Investigation of hydrogel membranes containing combination of gentamicin and dexamethasone for ocular delivery
Prabhakara Prabhu, Akhilesh Dubey, Vinod Parth, Vivek Ghate
pp. 214–225 · DOI: 10.4103/2230-973X.167684 · Published
Background:Hydrogel is a cross-linked network of polymers. Water penetrates these network causing swelling and giving the hydrogel a soft and rubbery consistency and there by maintaining the integrity of the membrane. Du…
- Article
Development and evaluation of in situ gel of pregabalin
Jyotsana R Madan, Bhushan R Adokar, Kamal Dua
pp. 226–233 · DOI: 10.4103/2230-973X.167686 · Published
Aim and Background:Pregabalin (PRG), an analog of gamma-aminobutyric acid, reduces the release of many neurotransmitters, including glutamate, and noradrenaline. It is used for the treatment of epilepsy; simple and compl…
- Article
Factorial designed 5-fluorouracil-loaded microsponges and calcium pectinate beads plugged in hydroxypropyl methylcellulose capsules for colorectal cancer
Ankita Gupta, Gaurav Tiwari, Ruchi Tiwari, Rishabh Srivastava
pp. 234–246 · DOI: 10.4103/2230-973X.167688 · Published
Introduction:The work was aimed to develop an enteric-coated hydroxypropyl methylcellulose (HPMC) capsules (ECHC) plugged with 5-fluorouracil (5-FU)-loaded microsponges in combination with calcium pectinate beads. Materi…
- Article
Dissolution enhancement of chlorzoxazone using cogrinding technique
Mihir K. Raval, Jaydeep M. Patel, Rajesh K. Parikh, Navin R. Sheth
pp. 247–258 · DOI: 10.4103/2230-973X.167689 · Published
Purpose:The aim of the present work was to improve rate of dissolution and processing parameters of BCS class II drug, chlorzoxazone using cogrinding technique in the presence of different excipients as a carrier. Materi…
- Article
Preparation and characterization of physicochemical properties of N, N-diethyl-meta-toluamide niosomes
Arezoo Amanatfard, Payam Khazaeli, Abbas Pardakhty, Moslem Lari Najafi, Amin Mohammadi
pp. 259–265 · DOI: 10.4103/2230-973X.167691 · Published
Introduction: The insect repellent compounds are used to protect humans, animals and plants against insect bites. Aromatic amides have insect repellent effects. N,N-diethyl-meta-toluamide (DEET) (C12H17NO) is one of the …
- Article
Development of novel multifunction directly compressible co-processed excipient by melt granulation technique
Nidhi Garg, Parijat Pandey, Deepak Kaushik, Harish Dureja
pp. 266–274 · DOI: 10.4103/2230-973X.167692 · Published
Introduction:The objective of the present investigation was to develop a novel multifunctional directly compressible co-processed excipient consisting of dibasic calcium phosphate anhydrous, polyethylene glycol 4000 (PEG…
- Article
Modified extrusion-spheronization as a technique of microencapsulation for stabilization of choline bitartrate using hydrogenated soya bean oil
Avinash Bhaskar Gangurde, Ajay Kumar Sav, Sharadchandra Dagadu Javeer, Kailas K Moravkar, Jaywant N Pawar, Purnima D Amin
pp. 275–283 · DOI: 10.4103/2230-973X.167696 · Published
Introduction: Choline bitartrate (CBT) is a vital nutrient for fetal brain development and memory function. It is hygroscopic in nature which is associated with stability related problem during storage such as developmen…