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International Journal of Pharmaceutical InvestigationNOW IN
Article

Synthesis, Spectral Characterization and Biological Evaluation of Cr(III) Complex with Mixed N,N and O-donor Ligands

R Govindharaju1★, N Muruganantham1, S Balasubramaniyan2, L Palanivelan2, B Jayalakshmi3, K Rajalakshmi4, T Ramachandramoorthy5★ Corresponding author

  1. 1Postgraduate and Research Department of Chemistry, Thanthai Hans Roever College (Autonomous), (Affiliated to Bharathidasan University), Perambalur, Tamil Nadu, INDIA.
  2. 2Postgraduate and Research Department of Chemistry, Government Arts College (Affiliated to Bharathidasan University), Ariyalur, Tamil Nadu, INDIA.
  3. 3Department of Chemistry, Syed Ammal Engineering College (Affiliated to Anna University), Ramanathapuram, Tamil Nadu, INDIA.
  4. 4Postgraduate and Research Department of Chemistry, Srimad Andavan Arts and Science College (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu, INDIA.
  5. 5Postgraduate and Research Department of Chemistry, Bishop Heber College (Autonomous), (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu, INDIA.

CORRESPONDENCE

R Govindharaju

Postgraduate and Research Department of Chemistry, Thanthai Hans Roever College (Autonomous), (Affiliated to Bharathidasan University), Perambalur, Tamil Nadu, INDIA.

argovindh@gmail.com

Volume 9, Issue 4 · pp. 158–163 · PUBLISHED · DOI: 10.5330/ijpi.2019.4.30

View on IJPI original site ↗

ABSTRACT

Objectives: 2-aminobenzonitrile is used as the starting materials for the synthesis of many biologically active compounds. The main objective of the study was to synthesize, characterization and biological evaluation of a binuclear bridged Cr(III) complex containing 2-aminobenzonitrile (N,N- donor) and octanoate ion (OC) as ligands. Methods: This study formulated, the required mole ratio of 2-aminobenzonitrile in methanol and sodium octanoate in ethanol were added to the chromium chloride in methanol followed by microwave irradiation for few seconds after each addition by using microwave oven and the precipitate was filtered off, washed with 1:1 ethanol: water and characterized by various spectral studies and biological significance. Results:The resulted complex was investigated by the help of elemental analysis, molar conductance, magnetic moment, electronic spectra, FT-IR, cyclic voltammetry, thermal analysis and powder-XRD tech- niques. The spectral data’s indicates that the geometry of the complex is octahedral. The antimicrobial activities of ligands and their Cr(III) complex were studied by agar-well diffusion method. The free radical scavenging activity of the complex and the ligands has been determined by measuring their interaction with the stable free radical DPPH. DNA-binding properties have been studied by fluorescence-emission method. Conclusion: The for- mulated Cr(III) complex showed moderate and potential activity against the tested bacteria, enhanced activity against the fungi and larger antioxidant activity as compared to the free ligands. The DNA binding study result sug- gests that the complex strongly binds to DNA.

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    Govindharaju, R., Muruganantham, N., Balasubramaniyan, S., Palanivelan, L., Jayalakshmi, B., Rajalakshmi, K., & Ramachandramoorthy, T. (). Synthesis, Spectral Characterization and Biological Evaluation of Cr(III) Complex with Mixed N,N and O-donor Ligands. International Journal of Pharmaceutical Investigation, 9(4), 158–163. https://doi.org/10.5330/ijpi.2019.4.30