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Article

Comparison of Topical Ivermectin and Oral Ivermectin in the Treatment of Human Scabies: A Randomized Controlled Trial

Swetabh Verma1, Marya Ahsan2★★ Corresponding author

  1. 1Department of Pharmacology, Darbhanga Medical College, Darbhanga, Bihar, India.
  2. 2Department of Pharmacology, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Kingdom of Saudi Arabia.

CORRESPONDENCE

Marya Ahsan

Department of Pharmacology, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Kingdom of Saudi Arabia.

marya.ahsan@gmail.com

Received: 04-08-2020; Revised: 09-10-2020; Accepted: 10-02-2021.

Volume 11, Issue 4 · pp. 134–139 · PUBLISHED 14 May 2021 · DOI: 10.4103/jpp.JPP_116_20

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ABSTRACT

Objective: To compare the topical and oral ivermectin (IVM) in the management of scabies. Materials and Methods: An open-labeled parallel randomized trial was conducted among patients of scabies. Group A (n = 51) received two applications of 0.5% topical IVM cream 1 week apart, while Groups B (n = 50) received single dose of oral IVM (200 µg/kg body weight. The scabies severity and pruritus severity on the Visual Analog Scale (VAS) were compared at baseline and at the end of the 1st, 2nd, and 4th weeks. Mann–Whitney U-test and Wilcoxon Signed-Rank test were used for statistical analysis. Results: Significant improvement in scabies severity was seen at the 1st and 2nd follow-up in both groups (P < 0.001). The cure rate was 2%, 96.1%, and 100% in Group A, while 68%, 98%, and 100% in Group B at each follow-up, respectively. Group B had significantly better improvement than Group A at the 1st follow-up (P < 0.001). Highly significant improvement in pruritus was seen at each visit in both groups (P < 0.001) with no difference between the groups (P > 0.05). Adverse events were reported nine and 12 times in Groups A and B, respectively. Conclusion: Two applications of 0.5% topical IVM cream and single dose of oral IVM are equally efficacious and safe for the treatment of scabies at the end of the 2nd and 4th weeks.

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    Verma, S., & Ahsan, M. (2021). Comparison of Topical Ivermectin and Oral Ivermectin in the Treatment of Human Scabies: A Randomized Controlled Trial. Journal of Pharmacology and Pharmacotherapeutics, 11(4), 134–139. https://doi.org/10.4103/jpp.JPP_116_20