Volume 13, Issue 3

Alanood Algarni

pp. 215–221 · DOI: 10.1177/0976500X221128643 · 2022

Diabetic ketoacidosis (DKA) is a medical emergency caused by the lack of insulin. Metabolic acidosis, hyperglycemia, and ketoacidosis are its defining features. Insulin deficiency can cause DKA either in the presence or …

Indumathi Prabath, Subhiksha Subramanian, Jamuna Rani

pp. 222–228 · DOI: 10.1177/0976500X221130851 · 2022

Tapinarof is a novel topical formulation approved recently, in May 2022, by the United States Food and Drug Administration to treat plaque psoriasis. Existing topical therapies for psoriasis are limited by systemic and l…

Mohammad Zubair Baba, S. Gomathy, Umair Wahedi

pp. 229–238 · DOI: 10.1177/0976500X221128855 · 2022

Oxidative stress plays a crucial role in the emergence of numerous neurodegenerative diseases, with protein accumulation and mitochondrial damage, which result in neurological disorders. To minimize oxidative stress, sev…

Anaiska Ray, Jayshri Sadashiv Jankar

pp. 239–245 · DOI: 10.1177/0976500X221128646 · 2022

Chromium is an essential trace element whose deficiency can cause impairment of glucose tolerance, growth and various biological functions. There are two isotopes of chromium-trivalent chromium and hexavalent chromium. B…

Queen Saikia, Ajit Hazarika, Ritu Mishra

pp. 246–257 · DOI: 10.1177/0976500X221129008 · 2022

Phosphodiesterase type 5 (PDE5) is a cyclic GMP (cGMP) specific protein. It hydrolyzes the phosphodiesterase linkage and catalyzes the conversion of cGMP to 5' GMP, which controls different physiological activities of th…

Parayil Varghese Christapher, Thanapakiam Ganeson, Suresh V. Chinni, Subramani Parasuraman

pp. 258–265 · DOI: 10.1177/0976500X221135691 · 2022

The coexistence of humans and animals has existed for centuries. Over the past decade, animal research has played a critical role in drug development and discovery. More and more diverse animals, including transgenic ani…

Ratna Prabha, Sumith K. Mathew, A. J. Joseph, Binu Susan Mathew

pp. 266–271 · DOI: 10.1177/0976500X221085804 · 2022

Aim: To determine the concentration of 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine (6-MMP), the interpatient variability, and the relationship with disease activity in patients with Chron’s disease on lon…

Santhosh Kumar Raju, Geetha S., Shobha Kamble

pp. 272–277 · DOI: 10.1177/0976500X221130841 · 2022

Objectives: To analyse the adverse drug reactions (ADRs) reported from clinical departments of a tertiary care hospital. Materials and Methods: A prospective, observational study to analyse the reported ADRs to the pharm…

Aparna Bagle, Spoorti Pujari, Krusha Shah, Shreyank Solanki, Chandrakala Singh

pp. 278–283 · DOI: 10.1177/0976500X221108533 · 2022

Objective: To evaluate the impact of ketamine following spinal anesthesia on the duration of postoperative analgesia and the need for analgesics. Methods: This was a prospective, randomized, double-blinded placebo-contro…

Venkata Aksheena Varahi Vedam, Mohan Krishna Ghanta, Suvarna Jyothi Kantipudi, Darling Chellathai David, Melanathuru Vijayalakshmi, Poojith Nuthalapati

pp. 284–292 · DOI: 10.1177/0976500X221128649 · 2022

Objectives: To find out the relation between homocysteine levels in peripheral blood and the effectiveness as well as the safety of haloperidol and olanzapine in schizophrenia treatment. Materials and Methods: A prospect…

Katharigatta N. Venugopala

pp. 293–299 · DOI: 10.1177/0976500X221138393 · 2022

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread rapidly and diffused to more than 180 countries at varying severities. This pandemic has accounted for increased mortality and morbidity in develope…