Allelic Variants in the Warfarin-related Genes VKORC1 and CYP2C9 in a Western Saudi Population

ABSTRACT

Objectives: To investigate the allele and genotype frequencies of the warfarin-related genes VKORC1 (-1639G>A), CYP2C9*2, and CYP2C9*3 among healthy Saudis. Materials and Methods: This cross-sectional study involved 125 unrelated healthy Saudis ages 18–60 years visiting the King Abdulaziz University Hospital (KAUH) in Jeddah, Western Saudi Arabia. The Oragene™ DNA saliva collection kits were used to collect and extract DNA from saliva samples. A polymerase chain reaction-restriction fragment length polymorphism analysis was used to detect the mutant alleles. Results: Over 51.4% of the Saudi participants carried one or more mutant alleles. The frequency of the VKORC1 (-1639G>A) allele in Saudi was relatively high at 54.8%. The frequencies of the CYP2C9 allele were 19.6% and 54% for the CYP2C9*2 and CYP2C9*3 alleles, respectively, which are substantially more abundant than in other populations. Conclusion: The observed high frequencies of VKORC1 (-1639G>A) and CYP2C9*2 and CYP2C9*3 polymorphisms suggest that genetic testing should be considered before initiating warfarin therapy to predict the optimal initial dose of warfarin and minimize warfarin-related side effects.

KEYWORDS

• Saudi.VKORC1
• CYP2C9*2
• CYP2C9*3
• polymorphisms

Showing references and in-text citations exactly as published.

• DOI10.1177/0976500X231189351Copy

RELATED ARTICLES

Matched on section and article type within this issue of JPP.

• Article · VOLUME 14, ISSUE 2Quercetin Exerts a Protective Effect on Ischemic Stroke-induced Memory Deficits in MiceChrismawan Ardianto, Dewi Lestari, Luthfia Hany Primadani, Dwi Retno Puspitasari, I Nengah Budi Sumartha, Khoirotin Nisak, Aniek Setiya Budiatin, Dewi Wara Shinta, Mareta Rindang Andarsari, Farida Ifadotunnikmah, Amar Daud Iskandar Abdullah, Mahardian Rahmadi, Junaidi Khotib · pp. 133–141Research ArticleSame type: Article
• Article · VOLUME 14, ISSUE 2N-Acetyl-l-Cysteine Ameliorations Renal Function Early After Renal Ischemia and Reperfusion; it is not Protective over a Long Term under a High-Sodium Diet in RatsRafael Canavel Pereira, Carolina Martinez Romão, Beatriz Santos Geoffroy Corrêa, Wagner Vasques Dominguez, Luzia Naôko Shinohara Furukawa · pp. 142–152Research ArticleSame type: Article
• Article · VOLUME 14, ISSUE 2Pediatric Antimicrobial Usage in a Secondary Care Hospital in Ras Al Khaimah, United Arab EmiratesSarah Dawood, Yasmin Sharifian, Masah Mardini, Duaa Jawhar, Laxminarayana Kurady Bairy, Suresh Kumar Srinivasamurthy · pp. 153–159Research ArticleSame type: Article
• Article · VOLUME 14, ISSUE 2The Science of Antioxidants: Balancing the Pros and Cons for Our HealthMueen Ahmed K. K. · pp. 160–162Same type: Article