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Article

Measurement of invasive blood pressure in rats

Subramani Parasuraman1★, Ramasamy Raveendran1★ Corresponding author

  1. 1Department of Pharmacology, Jawaharlal Institute of Postgradute Medical Education and Research, Pondicherry, India ABSTRACT Blood pressure (BP) is one of the vital parameters used to assess the cardiovascular functions of a mammal. BP is commonly recorded using invasive, noninvasive, and radio telemetry methods, but invasive blood pressure (IBP) recording is considered the gold standard. IBP provides a direct indication of the effect of the investigational products on the circulatory system. Recording the IBP in rodents is an essential part of the preliminary screening of any product to determine its effect on the cardiovascular system. The present article describes the measurement of the IBP in Wistar rats/Sprague Dawley rats. Key words: Carotid artery, invasive blood pressure, tracheostomy.

CORRESPONDENCE

Subramani Parasuraman

Department of Pharmacology, Jawaharlal Institute of Postgradute Medical Education and Research, Pondicherry, India ABSTRACT Blood pressure (BP) is one of the vital parameters used to assess the cardiovascular functions of a mammal. BP is commonly recorded using invasive, noninvasive, and radio telemetry methods, but invasive blood pressure (IBP) recording is considered the gold standard. IBP provides a direct indication of the effect of the investigational products on the circulatory system. Recording the IBP in rodents is an essential part of the preliminary screening of any product to determine its effect on the cardiovascular system. The present article describes the measurement of the IBP in Wistar rats/Sprague Dawley rats. Key words: Carotid artery, invasive blood pressure, tracheostomy.

parasuphd@gmail.com

Volume 3, Issue 2 · pp. 87–93 · PUBLISHED 2010 · DOI: 10.4103/0976-500X.95521

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ABSTRACT

Blood pressure (BP) is one of the vital parameters used to assess the cardiovascular functions of a mammal. BP is commonly recorded using invasive, noninvasive, and radio telemetry methods, but invasive blood pressure (IBP) recording is considered the gold standard. IBP provides a direct indication of the effect of the investigational products on the circulatory system. Recording the IBP in rodents is an essential part of the preliminary screening of any product to determine its effect on the cardiovascular system. The present article describes the measurement of the IBP in Wistar rats/Sprague Dawley rats.

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    Parasuraman, S., & Raveendran, R. (2010). Measurement of invasive blood pressure in rats. Journal of Pharmacology and Pharmacotherapeutics, 3(2), 87–93. https://doi.org/10.4103/0976-500X.95521