Volume 3, Issue 2

Methods

1. Article

   Measurement of invasive blood pressure in rats

   Subramani Parasuraman, Ramasamy Raveendran

   pp. 87–93 · DOI: 10.4103/0976-500X.95521 · Published 2010

   Blood pressure (BP) is one of the vital parameters used to assess the cardiovascular functions of a mammal. BP is commonly recorded using invasive, noninvasive, and radio telemetry methods, but invasive blood pressure (I…

Editorial

1. Forum Article

   Clinical trial ethics in India: One step forward, two steps back

   Anant Bhan

   pp. 95–97 · DOI: 10.4103/0976-500X.95501 · Published 2012

   The recent reporting of controversial drug trials being conducted by doctors of the government medical college and private practitioners on ‘mentally challenged’ patients in Indore has caused uproar.[5] It was alleged th…

Educational Forum

1. Article

   Pharmacotherapy for multidrug resistant tuberculosis

   Naveen Chhabra, M. L. Aseri, Ramakant Dixit, S. Gaur

   pp. 98–104 · DOI: 10.4103/0976-500X.95502 · Published 2012

   The current global concern in the treatment of tuberculosis (TB) is the emergence of resistance to the two most potent drugs namely, isoniazid and rifampicin. Emergence of multidrug resistance tuberculosis (MDR- TB) is n…

Mini Review

1. Article

   A review of antihistamines used during pregnancy

   Sumit Kar, Ajay Krishnan, Preetha K., Atul Mohankar

   pp. 105–108 · DOI: 10.4103/0976-500X.95503 · Published 2012

   Antihistamines are one of the most common drugs that are used extensively in various dermatological and nondermatological conditions. The use of H-1-antihistamines during pregnancy has been very controversial due to poss…

2. Article

   Ulipristal acetate, a progesterone receptor modulator for emergency contraception

   Shilpa P. Jadav, Dinesh M. Parmar

   pp. 109–111 · DOI: 10.4103/0976-500X.95504 · Published 2012

   Unwanted pregnancy is a global reproductive health problem. Emergency contraception is defined as the use of drug or device after unprotected or underprotected intercourse to prevent an unwanted pregnancy. 1.5 mg of levo…

Review Article

1. Review

   Epilepsy: Novel therapeutic targets

   Ashish P. Anovadiya, Jayesh J. Sanmukhani, C. B. Tripathi

   pp. 112–117 · DOI: 10.4103/0976-500X.95505 · Published 2012

   Despite of established and effective therapy for epilepsy, 20–25% patients develop therapeutic failure; this encourages finding newer drugs. Novel approaches target receptors which remain unaffected by conventional thera…

2. Review

   Vitamin D: The “sunshine” vitamin

   Rathish Nair, Arun Maseeh

   pp. 118–126 · DOI: 10.4103/0976-500X.95506 · Published 2012

   Vitamin D insufficiency affects almost 50% of the population worldwide. An estimated 1 billion people worldwide, across all ethnicities and age groups, have a vitamin D deficiency (VDD). This pandemic of hypovitaminosis …

3. Review

   Red carpeting the newer antidiabetics

   Dilip Gude

   pp. 127–131 · DOI: 10.4103/0976-500X.95507 · Published 2012

   The rapidly increasing prevalence of diabetes on a global scale beseeches an urgent need for newer and better treatment options. Our better understanding of the pathophysiology of diabetes has enabled a continual churn o…

Research Paper

1. Article

   Effect of rolipram, a phosphodiesterase enzyme type– 4 inhibitor, on γ-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress

   Amany Mohamed Shalaby, Sahar Mohamed Kamal

   pp. 132–137 · DOI: 10.4103/0976-500X.95509 · Published 2012

   Objectives: To investigate the alterations in GABA levels by rolipram in the model of depression. Materials and Methods: The alteration of GABA content by rolipram as a phosphodiesterase enzyme type-4 inhibitor in the fr…

2. Article

   Patient factors impacting antiretroviral drug adherence in a Nigerian tertiary hospital

   Kakjing D. Falang, P. Akubaka, N. S. Jimam

   pp. 138–142 · DOI: 10.4103/0976-500X.95511 · Published 2012

   Objective: To study the adherence levels and explore factors impacting them in out-patients on antiretroviral therapy (ART) at the AIDS Prevention Initiative in Nigeria antiretroviral clinic of the Jos University Teachin…

3. Article

   Cardiorenal benefits of early versus late cyclosporine to sirolimus conversion in a rat model

   José Sereno, Ana M. Romão, Belmiro Parada, Patrícia Lopes, Eugénia Carvalho, Frederico Teixeira, Flávio Reis

   pp. 143–148 · DOI: 10.4103/0976-500X.95513 · Published 2012

   Objective: To compare the cardiorenal effects of early versus late cyclosporine (CsA) to sirolimus (SRL) conversion, using a novel animal model that mimics these protocols used in the clinical practice, and focusing on b…

4. Article

   Association between altered thyroid state and insulin resistance

   Kunal B. Kapadia, Parloop A. Bhatt, Jigna S. Shah

   pp. 156–160 · DOI: 10.4103/0976-500X.95517 · Published 2012

   Objective: To determine the association between altered thyroid hormones and insulin resistance (IR). Materials and Methods: Eight euthyroid (EU), eight hypothyroid (HO), and eight hyperthyroid (HR) patients with no past…

5. Article

   Cortico-hippocampal salvage in chronic aluminium induced neurodegeneration by Celastrus paniculatus seed oil: Neurobehavioural, biochemical, histological study

   Mrinmoy Chakrabarty, Priyanka Bhat, Sweta Kumari, Avin D’Souza, K. L. Bairy, Abhishek Chaturvedi, Archana Natarajan, Mohandas Rao K. G., Shobha Kamath

   pp. 161–171 · DOI: 10.4103/0976-500X.95520 · Published 2012

   Objective: To investigate the effects of Celastrus paniculatus seed oil in preventing the onset of chronic aluminum induced cortico-hippocampal neurodegeneration and oxidative stress. Materials and Methods: An animal mod…

Research paper

1. Article

   Hepatoprotective activities of picroliv, curcumin, and ellagic acid compared to silymarin on carbon-tetrachloride-induced liver toxicity in mice

   C. Girish, S. C. Pradhan

   pp. 149–150 · DOI: 10.4103/0976-500X.95515 · Published 2012

   Introduction:To evaluate the hepatoprotective activity of active phytochemicals, picroliv, curcumin, and ellagic acid in comparison to silymarin in the mice model of carbon tetrachloride (CCl4) induced liver toxicity. In…

Report

1. Article

   The basic concepts of scientific research and scientific communication

   Pitchai Balakumar, Gowraganahalli Jagadeesh

   pp. 178–179 · DOI: 10.4103/0976-500X.95522 · Published 2012

   The 63rd Annual Conference of the Indian Pharmaceutical Congress (IPC) was held in Bengaluru, India, from 16 to 18 December 2011. It was hosted by the Karnataka state branch of the ‘Indian Pharmaceutical Association’. Th…

Research Letter

1. Article

   Evaluation of protective effect of Butea monosperma (lam.) Taub in experimental hepatotoxicity in rats

   Arti Gupta, N. R. Sheth, Sonia Pandey, Jitendra S. Yadav, D. R. Shah, B. Vyas, S. Joshi

   pp. 183–184 · DOI: 10.4103/0976-500X.95523 · Published 2012

   The liver is the second largest organ in the body, and is often seen as the most important one. Toxins, infectious agents, medications, and serum inflammatory mediators may result in a diverse range of disease processes,…

Research Letters

1. Article

   Antibiotic prescribing pattern in ophthalmology outpatient department in a tertiary care hospital

   Isabella Topno, B. Chennama, B. Yugandhar, S. Balakrishnan

   pp. 190–191 · DOI: 10.4103/0976-500X.95526 · Published 2012

   Drug utilization research is defined by World Health Organization (WHO) as the marketing, distribution, prescription and use of drugs in a society, with special emphasis on the resulting medical, social and economic cons…

2. Article

   Protective effects of apigenin against methyl methanesulfonate induced hsp70 expression in the third instar larvae of transgenic Drosophila melanogaster (hsp70- lacZ)Bg 9

   Yasir Hasan Siddique, Mohammad Afzal

   pp. · DOI: 10.4103/0976-500X.95525 · Published 2012

   A transgenic Drosophila melanogaster line expressing bacterial b-galactosidase as a response to stress was used in this study.[6] The flies and larvae were cultured on standard Drosophila food containing agar, cornmeal, …

3. Article

   Effect of Stereospermum tetragonum DC. in alloxan induced diabetic rats

   Isabella Topno, B. Chennama, B. Yugandhar

   pp. · DOI: 10.4103/0976-500X.95527 · Published 2012

   S. tetragonum root was collected from Tirunelveli district of Tamilnadu and identified by taxonomists of Tropical Botanic Garden and Research Institute (TBGRI) and a voucher specimen (TBGRI 8282) has been deposited. The …

Case Report

1. Article

   L-Asparginase induced cortical venous thrombosis in a patient with acute leukemia

   Biswajit Dubashi, Ankit Jain

   pp. 194–195 · DOI: 10.4103/0976-500X.95531 · Published 2012

   l-Asparginase is used for remission induction in acute lymphoblastic leukemia. We describe a case of 16-year-old boy who developed cortical venous thrombosis following the administration of l-Asparginase.

2. Article

   Ethionamide-induced gynecomastia

   Ramakant Dixit, Jacob George, Arun K. Sharma, Naveen chhabra, Suresh K. Jangir, Vikas Mishra

   pp. 196–199 · DOI: 10.4103/0976-500X.95532 · Published 2012

   Gynecomastia is very rare during antituberculosis chemotherapy. We describe a 38-year-old male patient who developed a painful gynecomastia following second-line drug therapy for multidrug-resistant pulmonary tuberculosi…

3. Article

   Docetaxel-induced hand foot syndrome: “No dose is a safe dose”

   Ankit Jain, Biswajit Dubashi

   pp. 200–201 · DOI: 10.4103/0976-500X.95534 · Published 2012

   Docetaxel is an important chemotherapeutic agent used in the management of many solid tumors. The most important side effect of this drug is myelosupression. We report a case of carcinoma breast that developed severe han…

4. Article

   Carbamazepine-induced erythema multiforme major in an epileptic patient with bipolar affective disorder

   Suneet K. Upadhyaya, Rangeel S. Raina, Archana Sharma, Vijay Thawani, Deepak Dimari

   pp. 202–204 · DOI: 10.4103/0976-500X.95537 · Published 2012

   Carbamazepine (CBZ) is frequently used for epilepsy and various psychiatric illnesses. It is known for its dermatological side effects which may range from mild rash to life-threatening reactions as Stevens Johnson syndr…

Interdisciplinary Communications

1. Article

   Problem solving interactive clinical seminars for undergraduates

   Bhavana Bhagya Rao, Vikram Kate

   pp. 205–206 · DOI: 10.4103/0976-500X.95539 · Published 2012

   In this context we have evaluated a different mode of clinical titled lectures, “Problem solving interactive clinical seminars (PSICS) based on clinical scenarios”, which is being conducted over the last few years in the…

Correspondence

1. Article

   Is gripe water baby-friendly?

   B. Adhisivam

   pp. 207–8 · DOI: 10.4103/0976-500X.95544 · Published 2012

   It has been hypothesized that the alcohol content of gripe water provides a soothing effect.[3] In some of the other commercial gripe waters, the alcohol content has been as high as 9% making even adults to get addicted.…

News and Views

1. Article

   Chronotherapy in hypertension

   pp. 209–209 · DOI: · Published 2012

   Chronotherapy may minimize side effects (fatigue and drowsiness), and maximize beneficial effects of antihypertensive medications. Ingestion of antihypertensives can affect circadian patterns of BP, but whether this tran…

2. Article

   Ketamine for fast alleviation of acute depression

   G. Sivagnanam

   pp. 210–210 · DOI: · Published 2012

   Medications (along with ECT, when specifically indicated) are the mainstays of treatment for severe major depressive disorder. It is a well-established fact that current medication treatments for depressive disorders req…

1. Article

   Clinical trials toolkit

   Jatinder Singh

   pp. 211–212 · DOI: 10.4103/0976-500X.95547 · Published 2012

   Clinical research aims to address the uncertainties that exist about treatments and interventions that are in use for a variety of diseases. This results in better choices for patients and more responsible decisions by p…

Molecules of the Millennium

1. Article

   Boceprevir: A new hope against hepatitis C virus

   Dick B. S. Brashier, Sushil Sharma, A. G. Mathur, Pragya Khare, Sparsh Gupta

   pp. 213–215 · DOI: 10.4103/0976-500X.95548 · Published 2012

   According to the statistics available, hepatitis C seems to affect 170 million people worldwide with varying prevalence according to the geographical distribution.[1] Out of 80% of infected population develop chronic hep…