Cover: Journal of Pharmacology and Pharmacotherapeutics
Journal of Pharmacology and Pharmacotherapeutics
Volume 3, Issue 3
2012 · pp. 215–294 · 22 articles
- Volume
- 3
- Issue
- 3
- Published
- 2012
- Pages
- 215–294
- Articles
- 22
- Sections
- 10
- ISSN
- Print - 0976-500X, Online - 0976-5018
- Journal
- JPP
In this issue
Editorial
- Forum Article
Are we going to allow the last nail on the coffin of animal experimentation to be nailed?
Gitanjali B.
pp. 215–216 · DOI: 10.4103/0976-500X.99415 · Published 2012
Animal experimentation in pharmacology has been the mainstay of practical pharmacology teaching in India for many decades. Undergraduate students in medicine and pharmacy as well as postgraduate students in pharmacology …
Review Article
- Review
MicroRNAs as newer therapeutic targets: A big hope from a tiny player
Hardik S. Ghelani, Manish A. Rachchh, Rina H. Gokani
pp. 217–227 · DOI: 10.4103/0976-500X.99416 · Published 2012
MicroRNAs (miRNAs) are a novel group of universally present small noncoding endogenous RNAs that regulate gene expression and protein coding by base pairing with the 3′ untranslated region (UTR) of target mRNAs. So they …
Mini Review
- Article
Comparative evaluation of adverse drug reaction reporting forms for introduction of a spontaneous generic ADR form
Anshi Singh, Parloop Bhatt
pp. 228–229 · DOI: 10.4103/0976-500X.99417 · Published 2012
Despite comprehensive and stringent phases of clinical trials and surveillance efforts, unexpected and serious adverse drug reactions (ADRs) repeatedly occur after the drug is marketed. ADR reporting is an important aspe…
Research Paper
- Article
Induction of cell-specific apoptosis and protection of mice from cancer challenge by a steroid positive compound from Zornia diphylla (L.) Pers
R. Arunkumar, S. Ajikumaran Nair, A. Subramoniam
pp. 233–241 · DOI: 10.4103/0976-500X.99420 · Published 2012
Objectives: Zornia diphylla (L.) Pers is an ethnomedical herb. The aim of the study is to scientifically verify the traditional use of Z. diphylla as an anticancer medicine. Materials and Methods: Different extracts, fra…
- Article
Impact of clinical pharmacist interventions on the cost of drug therapy in intensive care units of a tertiary care teaching hospital
Jisha M. Lucca, M. Ramesh, Gopalakrishna M. Narahari, N. Minaz
pp. 242–247 · DOI: 10.4103/0976-500X.99422 · Published 2012
Objective: To analyze clinical pharmacist interventions in the intensive care units (ICUs) setting of a tertiary care Indian hospital and to assess the pharmacoeconomic impact on drug-related problems (DRPs). Materials a…
- Article
Metformin ameliorates methotrexate-induced hepatotoxicity
Najah R. Hadi, Fadhil G. Al-Amran, Asma Swadi
pp. 248–253 · DOI: 10.4103/0976-500X.99426 · Published 2012
Objective: To study the effect of metformin on amelioration of hepatotoxicity induced by methotrexate. Materials and Methods: After a 2-weeks of acclimatization period, the animals were randomly separated into three grou…
- Article
A prospective study to compare the effects of pre, intra and post operative steroid (dexamethasone sodium phosphate) on post tonsillectomy morbidity
Nagaraj Bangalore Thimmasettaiah, Ravi Gowda Chandrappa
pp. 254–258 · DOI: 10.4103/0976-500X.99428 · Published 2012
Objective: To determine the effectiveness of dexamethasone on post tonsillectomy morbidities in patients with chronic tonsillitis. Materials and Methods: In this randomized double-blind study, 100 patients who underwent …
- Article
Prevalence and pattern of sexual dysfunction in married females receiving antidepressants: An exploratory study
Sandeep Grover, Ruchita Shah, Alakananda Dutt, Ajit Avasthi
pp. 259–265 · DOI: 10.4103/0976-500X.99430 · Published 2012
Objective: To study the prevalence and patterns of sexual dysfunctions in female patients receiving antidepressants. Materials and Methods: Eighty married female patients with a diagnosis of depressive disorder, currentl…
Research Letters
- Article
A retrospective study of extrapyramidal syndromes with second generation antipsychotics in the psychiatric unit of a tertiary care teaching hospital
Kingshuk Lahon, Harsha M Shetty, Amith Paramel, Gyaneshwar Sharma
pp. 266–268 · DOI: 10.4103/0976-500X.99435 · Published 2012
Extrapyramidal syndromes (EPS) are a group of neurological syndromes, resembling those seen in idiopathic Parkinson’s disease, which occur following antipsychotic medication. With the introduction of second generation an…
- Article
Physicians’ and patients’ opinions on the use of generic drugs
Antoni Sicras-Mainar, Ruth Navarro-Artieda
pp. 268–270 · DOI: 10.4103/0976-500X.99438 · Published 2012
low score to the information received on the substitution of a brand name drug by a GD, similar to the results of other studies,[2-5] suggesting the need for greater health education. Possible study limitations include t…
- Article
Determinants of success of loading dose diazepam for alcohol withdrawal: A chart review
Balaji Bharadwaj, Marie Bernard, Shivanand Kattimani, Ravi P. Rajkumar
pp. 270–271 · DOI: 10.4103/0976-500X.99440 · Published 2012
The use of loading dose diazepam for the treatment of alcohol withdrawal was first described by Sellers et al.[1] The same was used successfully in Indian patients by Manikant et al.[2] It involves the administration of …
- Article
Effect of Abrus precatorius and Amaranthus spinosus combination treatment on fertility in male rats
Yaseen Gigani, Amit Vekaria, Syed Amir Ali
pp. 272–273 · DOI: 10.4103/0976-500X.99441 · Published 2012
Curiously, it has long been known that hormonal suppression of gamete production was as feasible for men as it was for women. Studies conducted by World Health Organization (WHO) have shown that hormonal suppression of s…
- Article
A prescription survey in diabetes assessing metformin use in a tertiary care hospital in Eastern India
Manab Nandy, Ananya Mandal, Samar Banerjee, Krishnangshu Ray
pp. 273–275 · DOI: 10.4103/0976-500X.99444 · Published 2012
Metformin was prescribed in 304 prescriptions. It was the highest prescribed antidiabetic drug among hospital prescriptions (80% prescriptions). The reasons for not prescribing metformin included pregnancy, intolerance a…
Case Report
- Article
Toxic epidermal necrolysis caused by fluconazole in a patient with human immunodeficiency virus infection
Jacob George, Arun Sharma, Ramakant Dixit, Naveen Chhabra, Smita Sharma
pp. 276–278 · DOI: 10.4103/0976-500X.99445 · Published 2012
Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN) are rare but serious dermatologic disorders. These grave conditions present as medical emergency, requiring prompt diagnosis and management. These are often d…
- Article
Aripiprazole-induced oculogyric crisis (acute dystonia)
Jyotik T. Bhachech
pp. 279–281 · DOI: 10.4103/0976-500X.99446 · Published 2012
Aripiprazole is the third generation atypical antipsychotic and a dopamine serotonin system stabilizer (DSS) effective against positive and negative symptoms of schizophrenia. It has a low propensity for extrapyramidal s…
- Article
Acute myocardial involvement after heroin inhalation
Ritu Karoli, J. Fatima, Pushker Singh, Khursheed I. Kazmi
pp. 282–284 · DOI: 10.4103/0976-500X.99448 · Published 2012
Amongst the illicit drugs cocaine, amphetamines and cannabis have been studied and documented well to cause myocardial infarction by different mechanisms but there is very sparse data available on myocardial involvement …
Correspondence
- Article
L-Asparaginase induced thrombosis in acute lymphoblastic leukemia
Ketan P. Kulkarni
pp. 285–286 · DOI: 10.4103/0976-500X.99449 · Published 2012
As the authors have pointed out, the risk of symptomatic thrombosis in childhood acute leukemia is approximately 5%.[2] However, asymptomatic and symptomatic thrombosis may be observed in as many 73% of the ALL patients …
News and Views
- Article
Antidepressants
G. Sivagnanam
pp. 287–288 · DOI: · Published 2012
In the present day context, antidepressants are most commonly prescribed in depression and generalized anxiety disorders, not to mention a host of other neuropsychiatric and off-label indications. Thus, the magnitude of …
- Article
Gastric acid suppressing drugs and NSAIDs
G Sivagnanam
pp. 288–289 · DOI: · Published 2012
Based on several case reports implicating diclofenac, a population-based case-control study undertaken in UK, found that among all the NSAIDs, diclofenac usage has been associated with a modest increase in the risk of C.…
- Article
New HbA1c measure from 1 October 2012
G Sivagnanam
pp. 289–290 · DOI: · Published 2012
HbA1c levels, which are currently measured in percentage units, will be measured in millimoles per mole (mmol/ mol) by all countries from later part of 2012 onwards,[1] following a recommendation by the International Fed…
Webwise
- Article
Guide to Pharmacology
Jatinder Singh
pp. 291–292 · DOI: 10.4103/0976-500X.99455 · Published 2012
A multifold increase in the number of drug targets in recent years and has led to the need for organizing them in a logical manner in terms of a standardized nomenclature, pharmacological properties and details of their …
Molecules of Millennium
- Article
Fospropofol
Bharti Mahajan, Sandeep Kaushal, Rajesh Mahajan
pp. 293–294 · DOI: 10.4103/0976-500X.99457 · Published 2012
Intravenous anesthetic agents are mainly used for induction and maintenance of general anesthesia. Drugs such as thiopental, methohexital, etomidate, ketamine, and propofol are mainly used for induction of anesthesia as …