Aceclofenac induced Stevens‑Johnson/toxic epidermal necrolysis overlap syndrome
Kaderthambi Hajamohideen Nooru Ameen1, Rakesh Pinninti1★, Swathi Jami1★ Corresponding author
- 1Department of General Medicine, Government Stanley Hospital, Chennai, Tamil Nadu, India Case Report.
CORRESPONDENCE
Rakesh Pinninti
Department of General Medicine, Government Stanley Hospital, Chennai, Tamil Nadu, India Case Report.
Volume 4, Issue 1 · pp. 69–71 · PUBLISHED 2013 · DOI: 10.4103/0976-500X.107691
ABSTRACT
The purpose of this paper is to report a rare occurrence of Stevens‑Johnson/Toxic epidermal necrolysis (SJS/TEN) overlap syndrome after the use of aceclofenac. A 38 year old healthy adult male presented with rapidly evolving rash over face and upper body with ulceration of buccal mucosa and breathlessness after taking aceclofenac tablet. Naranjo score for this adverse drug event was six, thereby making it a probable adverse drug reaction. Despite aggressive fluid resuscitation and use of antihistamines and systemic steroids, patient’s health rapidly worsened and died within six hours of presentation. Aceclofenac induced SJS/TEN overlap is an extremely rare clinical association previously reported only once in medical literature. To the best of our knowledge, this is the first case report of such an association in the Indian population. We are presenting this case to highlight the serious adverse reactions possible from a routinely prescribed drug.
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Ameen, K. H. N., Pinninti, R., & Jami, S. (2013). Aceclofenac induced Stevens‑Johnson/toxic epidermal necrolysis overlap syndrome. Journal of Pharmacology and Pharmacotherapeutics, 4(1), 69–71. https://doi.org/10.4103/0976-500X.107691