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Journal of Pharmacology and PharmacotherapeuticsNOW IN
Journls JOURNAL OF PHARMACOLOGY AND PHARMACOTHERAPEUTICS Volume 4 · Issue 1 2013 · pp. 1–80
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Cover: Journal of Pharmacology and Pharmacotherapeutics

Journal of Pharmacology and Pharmacotherapeutics

Volume 4, Issue 1

2013 · pp. 1–80 · 20 articles

Volume
4
Issue
1
Published
2013
Pages
1–80
Articles
20
Sections
10
ISSN
Print - 0976-500X, Online - 0976-5018
Journal
JPP
EditorialMini ReviewReview ArticleResearch PaperResearch LetterLetter to the EditorCase ReportNews and ViewsWebwiseMolecules of the Millennium

In this issue

Editorial

  1. Forum Article

    When angels fall…are we lowering the standards of medical education in India?

    Gitanjali Batmanabane

    pp. 1–3 · DOI: 10.4103/0976-500X.107627 · Published 2013

    Medical teachers have been vested in the authority and the enormous responsibility of producing competent doctors. In a sense, they are the angels, who safe‑guard the health and well‑being of millions of our population. …

Mini Review

  1. Article

    The dawn of hedgehog inhibitors: Vismodegib

    Selvarajan Sandhiya, George Melvin, Srinivasamurthy Suresh Kumar, Steven Aibor Dkhar

    pp. 4–7 · DOI: 10.4103/0976-500X.107628 · Published 2013

    Cancer, one of the leading causes of death worldwide is estimated to increase to approximately 13.1 million by 2030. This has amplified the research in oncology towards the exploration of novel targets. Recently there ha…

  2. Article

    Strategies and challenges for safe injection practice in developing countries

    Sudesh Gyawali, Devendra Singh Rathore, P Ravi Shankar, Vikash Kumar KC

    pp. 8–12 · DOI: 10.4103/0976-500X.107634 · Published 2013

    Injection is one of the important health care procedures used globally to administer drugs. Its unsafe use can transmit various blood borne pathogens. This article aims to review the history and status of injection pract…

Review Article

  1. Review

    Accessibility and use of essential medicines in health care: Current progress and challenges in India

    Dipika Bansal, Vilok K. Purohit

    pp. 13–18 · DOI: 10.4103/0976-500X.107642 · Published 2013

    Essential Medicine Concept, a major breakthrough in health care, started in 1977 when World Health Organization (WHO) published its first list. Appropriate use of essential medicines is one of the most cost‑effective com…

Research Paper

  1. Article

    Effect of Casilan® on 13C-caffeine metabolism in overnight-fasted healthy Nigerian children

    Kazeem A. Oshikoya, Ken Smith

    pp. 19–26 · DOI: 10.4103/0976-500X.107648 · Published 2013

    Objective: To determine the effect of Casilan® on 13C-caffeine metabolism in healthy Nigerian children. Materials and Methods: Twelve healthy Nigerian children (male: six, female: six) aged 3–8 years were studied on thre…

  2. Article

    Effect of addition of either sitagliptin or pioglitazone in patients with uncontrolled type 2 diabetes mellitus on metformin: A randomized controlled trial

    Shalini Chawla, Nitin Kaushik, Narinder Pal Singh, Raktim Kumar Ghosh, Alpana Saxena

    pp. 27–32 · DOI: 10.4103/0976-500X.107656 · Published 2013

    Objective: To compare and study the dipeptidy1 peptidase‑4 (DPP‑4) inhibitors in combination with metformin against established combination therapies. Materials and Methods: This 16‑week study was designed to compare sit…

  3. Article

    Comparison of the efficacy and tolerability of ivabradine and ranolazine in patients of chronic stable angina pectoris

    Aditi Chaturvedi, Yogendra Singh, Harish Chaturvedi, Vijay Thawani, Sakshi Singla, Deepak Parihar

    pp. 33–33 · DOI: 10.4103/0976-500X.107663 · Published 2013

    Introduction: To compare the efficacy and tolerability of Ivabradine (IVA) and Ranolazine (RAN) in chronic angina patients. Materials and Methods: This was a follow‑on, open‑label trial conducted in a tertiary care hospi…

  4. Article

    Efficacy and safety of Tinospora cordifolia lotion in Sarcoptes scabiei var hominis‑infected pediatric patients: A single blind, randomized controlled trial

    Agnes L. Castillo, Marina O. Osi, John Donnie A. Ramos, Jean L. De Francia, Marylaine U. Dujunco, Peter F. Quilala

    pp. 39–46 · DOI: 10.4103/0976-500X.107668 · Published 2013

    Objective: To evaluate the clinical efficacy and safety of Tinospora cordifolia lotion including its cure rate and clearance time compared with permethrin lotion . Materials and Methods: A single blind, randomized, contr…

  5. Article

    Oleanolic acid prevents progression of streptozotocin induced diabetic nephropathy and protects renal microstructures in Sprague Dawley rats

    Vishal K. Dubey, Chandragouda R. Patil, Sarika M. Kamble, Priti S. Tidke, Kalpesh R. Patil, Pragnesh J. Maniya, Ramchandra B. Jadhav, Sudha P. Patil

    pp. 47–52 · DOI: 10.4103/0976-500X.107678 · Published 2013

    Objective: To study the effect of oleanolic acid (OA) on streptozotocin induced diabetic nephropathy in Sprague Dawley rats. Materials and Methods: Four weeks after intra‑peritoneal injection of streptozotocin (STZ; 55 m…

  6. Article

    Genetic variation and haplotype structure of the gene Vitamin K epoxide reductase complex, subunit 1 in the Tamilian population

    Dhakchinamoorthi Krishna Kumar, Deepak Gopal Shewade, Adithan Surendiran

    pp. 53–58 · DOI: 10.4103/0976-500X.107683 · Published 2013

    Objective: To study the genetic variation and haplotype structure of Vitamin K epoxide reductase complex, subunit 1 (VKORC1) gene in the Tamilian population. Materials And Methods: The study was performed on 210 unrelate…

Research Letter

  1. Article

    Prescribing pattern of gastroprotective agents with non-steroidal anti-inflammatory drugs

    V. S. Manohar, M Vinay, T. Jayasree, P. V. Kishan, S. Ubedulla, Rohit Dixit

    pp. 59–60 · DOI: 10.4103/0976-500X.107684 · Published 2013

    Non‑steroidal anti‑inflammatory drugs (NSAIDs) are most commonly used drugs for management of pain and inflammation. They represent a most widely prescribed class of medications and are used as over the counter drugs. NS…

  2. Article

    A study of non-prescription usage of antibiotics in the upper respiratory tract infections in the urban population

    Sangeeta Bhanwra

    pp. 62–64 · DOI: 10.4103/0976-500X.107687 · Published 2013

    In recent years the use and the overuse of antibiotics to treat Upper Respiratory Tract Infections (URTIs) has resulted in the development of resistance patterns across widespread areas. Most URTIs are self‑limiting vira…

  3. Article

    Calcium channel blocking activity of a dihydropyrimidine derivative (BKVIII) on rabbit’s aortic strip

    Rakesh Kumar, Balbir Kaur, V. K. Bajaj

    pp. 64–66 · DOI: 10.4103/0976-500X.107688 · Published 2013

    Test compound, 5‑Acyl‑6‑methyl‑4 (2′,3′‑methylenedioxy) phenyl‑2‑S‑ethyl‑1,4‑dihydropyrimidine have a calcium channel blocking activity and showed relaxant effect on aortic smooth muscle in higher doses as compared with …

Letter to the Editor

  1. Article

    A structured course in laboratory animal science for postgraduates: Is it a necessity?

    Syed I. Shehnaz, Anoop K. Agarwal

    pp. 67–68 · DOI: 10.4103/0976-500X.107689 · Published 2013

    The utilization of AE in biomedical research demands a certain level of knowledge and manual dexterity in the scientists conducting the research. There is a wide diversity in the postgraduate curricula with respect to an…

Case Report

  1. Article

    Aceclofenac induced Stevens‑Johnson/toxic epidermal necrolysis overlap syndrome

    Kaderthambi Hajamohideen Nooru Ameen, Rakesh Pinninti, Swathi Jami

    pp. 69–71 · DOI: 10.4103/0976-500X.107691 · Published 2013

    The purpose of this paper is to report a rare occurrence of Stevens‑Johnson/Toxic epidermal necrolysis (SJS/TEN) overlap syndrome after the use of aceclofenac. A 38 year old healthy adult male presented with rapidly evol…

  2. Article

    An unusual cause of cardiac arrest in a hospitalized patient

    Ranjan Shetty K., Anil Tumkur, Krishnamurthy Bhat, Biby Chacko

    pp. 72–73 · DOI: 10.4103/0976-500X.107692 · Published 2013

    We present an unusual case of 24 year old male who was hospitalized for dental procedure and developed cardiac arrest 2 days after the procedure. The patient presented with swelling of buccal cavity for which a biopsy wa…

News and Views

  1. Article

    Continuing β-blockers after noncardiac surgery improves patient outcomes and lowers mortality

    G G

    pp. 74–75 · DOI: 10.4103/0976-500X.107694 · Published 2013

    In a study to determine the effect of β‑blocker continuation on outcomes in patients undergoing elective noncardiac surgery, it was found that (after adjusting for risk characteristics), failure to continue β‑blocker tre…

  2. Article

    Severe morning sickness patients get relief from anti-seizure drug

    Sivagnanam G

    pp. 75–75 · DOI: · Published 2013

    In a pilot study involving seven pregnant subjects with hyperemesis gravidarum, it has been found that therapy with gabapentin was associated with mean reductions in nausea and emesis from baseline to days 12-14 of 80% a…

Webwise

  1. Article

    Critical appraisal skills programme

    Jatinder Singh

    pp. 76–7 · DOI: 10.4103/0976-500X.107697 · Published 2013

    A methodological approach coupled with the right tools and skills to match these methods is essential for finding meaningful results. The internet has redefined and simplified search capabilities of individuals by ensuri…

Molecules of the Millennium

  1. Article

    Ticagrelor: An emerging oral antiplatelet agent

    Shivani Juneja, Kanchan Gupta, Sandeep Kaushal

    pp. 78–80 · DOI: 10.4103/0976-500X.107698 · Published 2013

    Acute coronary syndrome (ACS) is a leading cause of myocardial infarction in the world. It is one of the major cause of mortality in the present lifestyle scenario and a main reason for hospital admissions. A critical ro…