Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats
Mossad Gamaleddin Ahmed Elsayed1, Ashraf Abdelhakim Ahmed Elkomy1, Mahmoud Salem Gaballah1, Mohamed Elbadawy1★★ Corresponding author
- 1Departments of Pharmacology, and Pathology, Faculty of Veterinary Medicine, Benha University, Egypt.
CORRESPONDENCE
Mohamed Elbadawy
Departments of Pharmacology, and Pathology, Faculty of Veterinary Medicine, Benha University, Egypt.
Volume 5, Issue 1 · pp. 33–33 · PUBLISHED 2014 · DOI: 10.4103/0976-500X.124419
ABSTRACT
Objectives: To investigate the nephrotoxic effect and biochemical alterations induced by cefepime in rats. Materials and Methods: Cefepime was administered intramuscularly at doses of 45, 90 and 180 mg/kg b.wt. once daily for 5 consecutive days. The serum and urine samples were used for quantitative determination of urea, creatinine, glucose, total protein, calcium, sodium and potassium. The histopathological examination of kidney tissues was performed 1, 4 and 8 days after the last dose of cefepime administration. Results: Cefepime induced a significant increase in the total amount of urine per day, urea and creatinine concentration in the serum and urine and significant decrease in their clearance. Cefepime also caused a significant gluocosuria and proteinuria and significant decrease in their serum concentrations. The effect of cefepime on serum and urine concentrations of calcium, sodium and potassium were also determined. Cefepime injection in the three tested doses caused renal tubular, glomerular and vascular changes. The severity of these changes was dose dependent. In conclusion, these results suggest a possible contribution of cefepime in the nephrotoxicity and biochemical alterations, especially at high doses. Therefore, the renal functions should be monitored during the cefepime therapy.
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Elsayed, M. G. A., Elkomy, A. A. A., Gaballah, M. S., & Elbadawy, M. (2014). Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats. Journal of Pharmacology and Pharmacotherapeutics, 5(1), 33–33. https://doi.org/10.4103/0976-500X.124419