Volume 5, Issue 1

Antidotes: Where are they when needed?

Gitanjali Batmanabane

pp. 1–3 · DOI: 10.4103/0976-500X.124403 · Published 2014

It is estimated that nearly 45,900 people in India die of snake bite,—the highest mortality rate in the world for snake bite.[1] Those who die are from the lower socioeconomic groups, such as farmers, villagers, children…

Dry antibiotic pipeline: Regulatory bottlenecks and regulatory reforms

Sandeep Kumar Gupta, Roopa P. Nayak

pp. 4–5 · DOI: 10.4103/0976-500X.124405 · Published 2014

Dextropropoxyphene ban in India: Is there a case for reconsideration?

Yatan Pal Singh Balhara

pp. 8–9 · DOI: 10.4103/0976-500X.124406 · Published 2014

Dextropropoxyphene is a synthetic weak opioid used as analgesic both as standalone as well as in combination with acetaminophen for more than 50 years. Ministry of Health and Family Welfare, Government of India has issue…

The new factor Xa inhibitor: Apixaban

Sangeeta Bhanwra, Kaza Ahluwalia

pp. 12–14 · DOI: 10.4103/0976-500X.124409 · Published 2014

Cardiovascular diseases are still the most important cause of morbidity and mortality worldwide and anti‑thrombotic treatment is widely used as a result. The currently used drugs include heparin and its derivatives, vita…

Drug utilization pattern and pharmacoeconomic analysis in geriatric medical in-patients of a tertiary care hospital of India

Binit N. Jhaveri, Tejas K. Patel, Manish J. Barvaliya, C. B. Tripathi

pp. 15–16 · DOI: 10.4103/0976-500X.124411 · Published 2014

Objective: To evaluate drug utilization pattern in terms of defined daily dose along with pharmacoeconomic analysis in geriatric patients admitted in medical ward of a tertiary care hospital. Materials and Methods: Retro…

Diethylentriaminepenta acetic acid glucose conjugates as a cell permeable iron chelator

Mona Mosayebnia, Mehdi Shafiee‑Ardestani, Parvin Pasalar, Mojgan Mashayekhi, Massoud Amanlou

pp. 27–28 · DOI: 10.4103/0976-500X.124416 · Published 2014

Objective: To find out whether DTPA-DG complex can enhance clearance of intracellular free iron. Materials and Methods: Diethylenetriaminepentaacetic acid‑D‑deoxy‑glucosamine (DTPA‑DG) was synthesized and examined for it…

Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats

Mossad Gamaleddin Ahmed Elsayed, Ashraf Abdelhakim Ahmed Elkomy, Mahmoud Salem Gaballah, Mohamed Elbadawy

pp. 33–33 · DOI: 10.4103/0976-500X.124419 · Published 2014

Objectives: To investigate the nephrotoxic effect and biochemical alterations induced by cefepime in rats. Materials and Methods: Cefepime was administered intramuscularly at doses of 45, 90 and 180 mg/kg b.wt. once dail…

Studies on sensitivity of zebrafish as a model organism for Parkinson’s disease: Comparison with rat model

Dinesh T. Makhija, Aarti G. Jagtap

pp. 39–46 · DOI: 10.4103/0976-500X.124422 · Published 2014

Objective: To determine the utility of zebra fish as an animal model for Parkinson’s disease (PD) in comparison with rat model. Materials and Methods: MTT assay was performed on rat and zebrafish brain synaptosomal fract…

Amikacin-triggered anaphylaxis: Should we go for skin test?

Sukhen Samanta, Sujay Samanta, Abhishek Jha

pp. 53–54 · DOI: 10.4103/0976-500X.124424 · Published 2014

Seed germination: An alternative to animal model to teach bioassay principles

Nagendra I. M. Nayak, Prasanna Lakshmi

pp. 56–58 · DOI: 10.4103/0976-500X.124426 · Published 2014

Anticonvulsant hypersensitivity syndrome associated with carbamazepine administration: Case series

Maulin Mehta, Jay Shah, Tejas Khakhkhar, Rima Shah, K. G. Hemavathi

pp. 59–60 · DOI: 10.4103/0976-500X.124428 · Published 2014

Hypersensitivity reactions are common adverse drug reactions (ADRs) associated with antiepileptics. Carbamazepine is one of the routinely prescribed drugs for the treatment of epilepsy and neuropathic pain. ADRs due to c…

Periodic paralysis: An unusual presentation of drug‑induced hyperkalemia

Poonam Agrawal, Deepti Chopra, Surajeet K. Patra, Himanshu Madaan

pp. 63–64 · DOI: 10.4103/0976-500X.124429 · Published 2014

Hyperkalemia is a life-threatening electrolyte abnormality. The most common cause of hyperkalemia includes renal disease and ingestion of medications. Drug-induced hyperkalemia may develop in patients with underlying ren…

Cholestatic presentation of yellow phosphorus poisoning

C. P. Lakshmi, Amit Goel, Debdatta Basu

pp. 67–69 · DOI: 10.4103/0976-500X.124430 · Published 2014

Yellow phosphorus, a component of certain pesticide pastes and fireworks, is well known to cause hepatotoxicity. Poisoning with yellow phosphorus classically manifests with acute hepatitis leading to acute liver failure …

A study with spoof paper - reflection of reviewing processes in open - access journals

Sridharan Kannan, Sivaramakrishnan Gowri

pp. 70–70 · DOI: 10.4103/0976-500X.124427 · Published 2014

Antibiotics with a curse of cardiovascular risk

G Sivagnanam

pp. 71–72 · DOI: · Published 2014

An evolving curse on paracetamol use in children

Sivagnanam G

pp. 72–72 · DOI: · Published 2014

The association between acetaminophen and asthma - should its pediatric use be banned? A huge epidemiological effort made all over the world to cast some light on the origin of asthma and its recent increase in prevalenc…

Antibiotics to end the curse of low back ache

pp. 71–71 · DOI: · Published 2014

Essential medicines and health products information portal

P. Ravi Shankar

pp. 74–5 · DOI: 10.4103/0976-500X.124434 · Published 2014

Essential medicines play an important role in improving access to medicines for the majority of the world’s population. The concept of a carefully selected list of medicines of assured quality that meet the majority of h…

Bedaquiline: A novel drug to combat multiple drug-resistant tuberculosis

Divya Goel

pp. 76–78 · DOI: 10.4103/0976-500X.124435 · Published 2014

Tuberculosis (TB) is among the most common infectious diseases and continues as a major global health problem. The scenario is worsened by the emergence and spread of multiple drug-resistant tuberculosis (MDR-TB) and ext…