Volume 4, Issue 4

2013 · pp. 227–308 · 18 articles

Volume: 4
Issue: 4
Published: 2013
Pages: 227–308
Articles: 18
Sections: 7
ISSN: Print - 0976-500X, Online - 0976-5018
Journal: JPP

Editorial Mini Review Research Paper Research Letter Case Report Educational Forum Webwise

In this issue

Editorial

Forum Article
Pioglitazone suspension and its aftermath: A wake up call for the Indian drug regulatory authorities
Arif Hashmi
pp. 227–229 · DOI: 10.4103/0976-500X.119705 · Published 2013
Pioglitazone, the commonly used antidiabetic drug was placed under suspension in June (June 18, 2013). The suspension was promulgated in the Government gazette.[1] It was not recommended by the Drug Technical Advisory Bo…

Mini Review

Article
Cabazitaxel: A novel taxane for metastatic castration‑resistant prostate cancer‑current implications and future prospects
Afroz Abidi
pp. 230–237 · DOI: 10.4103/0976-500X.119704 · Published 2013
Recent advances in the management of prostate cancer have shown considerable development with time and many novel therapeutic agents have been approved over the past years. For patients with metastatic castration‑resista…

Research Paper

Article
Anti-inflammatory activity of calcium channel blocker lercanidipine hydrochloride
Prathap Vasigar, Mounissamy Batmanabane
pp. 238–242 · DOI: 10.4103/0976-500X.119707 · Published 2013
Objective: To evaluate the anti-inflammatory effect of the third-generation CCB, lercanidipine. Materials and Methods: The ability of lercanidipine to reduce inflammation in carrageenan‑induced paw edema in rats was eval…
Article
Three‑way, three‑period, crossover bioequivalence study of single oral dose of three brands of 300 mg phenytoin sodium tablets marketed in India, on healthy Indian human volunteers
Maulik S. Doshi, Anuja A. Naik, Mohit R. Mehta, Nithya J. Gogtay, Urmila M. Thatte, Mala D. Menon
pp. 243–246 · DOI: 10.4103/0976-500X.119709 · Published 2013
Objective: To compare the bioavailability of two brands of phenytoin sodium tablets available in the Indian market using EptoinTM as the reference. Materials and Methods: A randomized, assessor‑blind, three‑way crossover…
Article
Evaluation of a new computerized psychometric test battery: Effects of zolpidem and caffeine
Raveendranadh Pilli, MUR Naidu, Usharani Pingali, JC Shobha
pp. 247–248 · DOI: 10.4103/0976-500X.119710 · Published 2013
Objective: To evaluate the effects of centrally active drugs using a new indigenously developed automated psychometric test system and compare the results with that obtained using pencil- and paper-based techniques. Mate…
Article
Virtual screening studies reveal linarin as a potential natural inhibitor targeting CDK4 in retinoblastoma
Muthukumaran Sivashanmugam, Chandana Raghunath, Umashankar Vetrivel
pp. 256–264 · DOI: 10.4103/0976-500X.119711 · Published 2013
Objective: To find out whether linarin can be used as a potential natural inhibitor to target CDK4 in retinoblastoma using virtual screening studies. Materials and Methods: In this study, molecular modeling and protein s…
Article
Expression of cFos and brain‑derived neurotrophic factor in cortex and hippocampus of ethanol‑withdrawn male and female rats
Paul E. Alele, Leslie L. Devaud
pp. 265–274 · DOI: 10.4103/0976-500X.119712 · Published 2013
Objective: To map areas of brain activation (cFos) alongside changes in levels of brain-derived neurotrophic factor (BDNF) to provide insights into neuronal mechanisms contributing to previously observed sex differences …
Article
Apoptosis amelioration through hypothermic reperfusion in heart transplant
Fadhil G. Al‑Amran
pp. 275–280 · DOI: 10.4103/0976-500X.119713 · Published 2013
Objective: To investigate the effects of two different sets of graft temperature during perfusion on myocardial protection in the immediate post transplantation period in rats. Materials and Methods: Rats grouped into: S…

Research Letter

Article
Inadequate pain relief for patients with trauma: A cause for concern?
Sadasivam Balakrishnan, Ratinder Jhaj, Vishnu Raj
pp. 281–281 · DOI: 10.4103/0976-500X.119714 · Published 2013
Pain relief is the major reason why patients come to a hospital.[1] Trauma is a chief cause of pain and suffering.[2] Road traffic accidents (RTA) are on the increase due to a variety of factors. Crush injuries and fract…
Article
Modulation of conditioned avoidance response and quetiapine‑induced metabolic syndrome by rosuvastatin and CDP‑choline in rats
Ahmad Shafique, K. K. Pillai, Abdi Sayed Aliul Hasan, A. K. Najmi
pp. 283–285 · DOI: 10.4103/0976-500X.119716 · Published 2013
The rats (Wistar rat) were divided into nine groups, each group containing eight rats. In this study, psychotic symptoms were induced in rats through Conditioned Avoidance Response (CAR) using Cook’s pole climbing appara…
Article
Cardiovascular medications among the critically ill patients of a tertiary care hospital: A drug utilization study
Lisha Jenny John, Padmini Devi, Shoba Guido
pp. 285–287 · DOI: 10.4103/0976-500X.119717 · Published 2013
Cardiovascular disorders are one of the leading causes of mortality and morbidity. The patients admitted to the medical intensive care unit (MICU) represent a diverse patient population with variable demographic characte…

Case Report

Article
Paroxetine in the treatment of recurrent brief depressive disorder
Sathya Prakash, Piyali Mandal, Rajesh Sagar
pp. 288–290 · DOI: 10.4103/0976-500X.119718 · Published 2013
Recurrent brief depressive disorder is now a well‑recognized type of depressive disorder. However, there is still no clear evidence base for its treatment. The efficacy of several drugs including antidepressants and mood…
Article
Phenytoin induced Stevens-Johnson syndrome exacerbated by cefepime
Varsha A. Prabhu, Sahiti Doddapaneni, Girish Thunga, Rajakannan Thiyagu, M. Mukyaprana Prabhu, Kushal Naha
pp. 291–293 · DOI: 10.4103/0976-500X.119719 · Published 2013
Steven Johnson syndrome (SJS) is a rare drug induced mucocutaneous reaction. Here, we present an elaborate report of a 28‑year‑old female patient who developed Phenytoin induced SJS, which was exacerbated by cefepime.
Article
Elevation of blood ciclosporin levels by voriconazole leading to leukoencephalopathy
Qu Caihong, Liu Weimin, Zhu Jieming
pp. 294–297 · DOI: 10.4103/0976-500X.119721 · Published 2013
We report that one 18‑year‑old female patient with no epilepsia history developed severe epileptiform seizures while she was receiving “ciclosporin A (CsA)-mycophenolate-methylprednisolone” antirejection therapy after co…
Article
Idiopathic intracranial hypertension secondary to ingestion of Morinda coreia and Azadirachta indica leaves extract in infant
Thirunavukkarasu Arun Babu, Shanthi Ananthakrishnan
pp. 298–299 · DOI: 10.4103/0976-500X.119722 · Published 2013
We report a case of idiopathic intracranial hypertension (IIH) secondary to ingestion of Morinda coreia (Nonan) and Azadirachta indica (Neem) leaves extract in a nine months old child. This herbal extract is believed to …
Article
A rare case of ethambutol induced pulmonary eosinophilia
Kaushik Saha, Ankan Bandyopadhyay, Amitabha Sengupta, Debraj Jash
pp. 300–302 · DOI: 10.4103/0976-500X.119724 · Published 2013
Antitubercular drug (ATD) induced eosinophilic lung disease is a rare phenomenon. It usually occurs due to isoniazid and para amino salicylic acid. A 34-year-male of sputum positive pulmonary tuberculosis, on antitubercu…

Educational Forum

Article
How to calculate sample size in animal studies?
Jaykaran Charan, N. D. Kantharia
pp. 303–304 · DOI: 10.4103/0976-500X.119726 · Published 2013
Calculation of sample size is one of the important component of design of any research including animal studies. If a researcher select less number of animals it may lead to missing of any significant difference even if …

Webwise

Article
The pharmacovigilance toolkit
P. Ravi Shankar
pp. 307–308 · DOI: · Published 2013
Pharmacovigilance (PV), a key intervention for promoting the safe and rational use of medicines is especially important in developing countries where there is often no legal requirement for medicines to be tested in indi…