Volume 4, Issue 4S

2013 · pp. 1–6 · 19 articles

Volume: 4
Issue: 4S
Published: 2013
Pages: 1–6
Articles: 19
Sections: 8
ISSN: Print - 0976-500X, Online - 0976-5018
Journal: JPP

Editorial Commentary Review Article Case Review Mini Review Research Article Report Case Series

In this issue

Editorial

Forum Article
Pharmacovigilance in Calabria (Italy): Local experiences resonate international relevance
Emilio Russo, Giovambattista De Sarro
pp. 1–3 · DOI: 10.4103/0976-500X.120938 · Published 2013
Pharmacovigilance and all drug safety issues are relevant for everyone whose life is touched in any way by medical interventions.[1] Pharmacovigilance is defined by the World Health Organization (WHO) as “the science and…

Commentary

Article
Pharmacovigilance and the Italian Medicines Agency
Giuseppe Pimpinella, Loriana Tartaglia
pp. 4–6 · DOI: 10.4103/0976-500X.120940 · Published 2013
The new European Union (EU) regulations on pharmacovigilance require that the national systems are strengthened in order to fit the new requirements. The Italian Pharmacovigilance System, coordinated by the Italian Medic…
Article
Informatics applied to pharmacovigilance: Future perspectives
Michele Menniti, Annamaria Menniti, Marinella Patanè, Stefania Esposito, Chiara Giofrè, Rossana Aiello, Emilio Russo
pp. S43–S44 · DOI: 10.4103/0976-500X.120950 · Published 2013
Spontaneous adverse drugs reaction (ADRs) reporting represents a precious resource for control and information about the drug’s safety and pharmacovigilance. The current reporting system is mainly based on handwritten fo…
Article
Limitations and obstacles of the spontaneous adverse drugs reactions reporting: Two “challenging” case reports
Caterina Palleria, Christian Leporini, Serafina Chimirri, Giuseppina Marrazzo, Sabrina Sacchetta, Lucrezia Bruno, Rosaria M. Lista, Orietta Staltari, Antonio Scuteri, Francesca Scicchitano, Emilio Russo
pp. S66–S67 · DOI: 10.4103/0976-500X.120955 · Published 2013
Introduction: Nowadays, based on several epidemiological data, iatrogenic disease is an emerging public health problem, especially in industrialized countries. Adverse drugs reactions (ADRs) are extremely common and, the…

Review Article

Review
Pharmacovigilance in Asia
Pipasha Biswas
pp. S7–S8 · DOI: 10.4103/0976-500X.120941 · Published 2013
An increase in drug safety concerns in recent years with some high profile drug withdrawals have led to raising the bar by various stakeholders more importantly by the regulatory authorities. The number of Adverse Drug R…
Review
Pharmacovigilance in Italy: An overview
Carmela Mazzitello, Stefania Esposito, Adele E. De Francesco, Annalisa Capuano, Emilio Russo, Giovambattista De Sarro
pp. S20–S21 · DOI: 10.4103/0976-500X.120942 · Published 2013
Introduction: Spontaneous reporting of adverse drug reactions (ADRs) is the basis of pharmacovigilance. In fact, ADRs are associated with a high degree of morbidity and mortality. However, underreporting by all healthcar…
Review
Clinical and economic burden of adverse drug reactions
Janet Sultana, Paola Cutroneo, Gianluca Trifirò
pp. S73–S74 · DOI: 10.4103/0976-500X.120957 · Published 2013
Adverse drug reactions (ADRs) are unwanted drug effects that have considerable economic as well as clinical costs as they often lead to hospital admission, prolongation of hospital stay and emergency department visits. R…

Case Review

Article
Abatacept in psoriatic arthritis: Case report and short review
Francesco Ursini, Saverio Naty, Emilio Russo, Rosa Daniela Grembiale
pp. S29–S30 · DOI: 10.4103/0976-500X.120943 · Published 2013
Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting about 6-10% of patients with cutaneous psoriasis. According to current knowledge, activated T-cells seem to play a pivotal role in the pathogenesis of…
Article
Management of dermatologic toxicities associated with monoclonal antibody epidermal growth factor receptor inhibitors: A case review
Christian Leporini, Francesca Saullo, Gianfranco Filippelli, Antonio Sorrentino, Maria Lucia, Gino Perri, Gaetana Gattuta, Stefania Infusino, Rosa Toscano, Gianluca Dima, Virginia Olivito, Laura Paletta, Ugo Bottoni, Giovambattista Sarro
pp. S78–S79 · DOI: 10.4103/0976-500X.120966 · Published 2013
Introduction: The epidermal growth factor receptor inhibitors (EGFRIs), cetuximab and panitumumab, represent an effective treatment option for patients affected by metastatic colorectal cancer (mCRC); furthermore, they a…
Article
Nexavar®-related adverse reactions: Calabrian (Italy) experience for sorafenib exposition in 2012
Felisa Cilurzo, Orietta Staltari, Marinella Patanè, Michele Ammendola, Caterina Garaffo, Eugenio Donato Paola
pp. S86–S86 · DOI: 10.4103/0976-500X.120971 · Published 2013
Hepatocellular carcinoma (HCC) remains a major global health problem and Calabria in the south of Italy is not an exception. Sorafenib is the first and only Food and Drug Administration approved drug for the treatment of…
Article
A possible case of natalizumab-dependent suicide attempt: A brief review about drugs and suicide
Laura Mumoli, Miriam Ciriaco, Antonio Gambardella, Giuseppe Nicodemo Bombardiere, Paola Valentino, Caterina Palleria, Angelo Labate, Emilio Russo
pp. S90–S91 · DOI: 10.4103/0976-500X.120974 · Published 2013
β-Interferon therapy is known to be a potential trigger of suicidal behavior, but this effect has not been previously reported for other multiple sclerosis (MS) treatments, such as, natalizumab. Here we report the case h…
Article
Corticosteroid-related central nervous system side effects
Miriam Ciriaco, Pasquale Ventrice, Gaetano Russo, Maria Scicchitano, Giovanni Mazzitello, Francesca Scicchitano, Emilio Russo
pp. S94–S95 · DOI: 10.4103/0976-500X.120975 · Published 2013
Corticosteroids have been used since the 50s as anti-inflammatory and immunosuppressive drugs for the treatment of several pathologies such as asthma, allergy, rheumatoid arthritis, and dermatological disorders. Corticos…
Article
The safety of ketoprofen in different ages
Claudia Carbone, Pierandrea Rende, Pasquale Comberiati, Domenico Carnovale, Maria Mammì, Giovambattista De Sarro
pp. S99–S100 · DOI: 10.4103/0976-500X.120967 · Published 2013
Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID), which acts by blocking cyclooxygenase (COX 1 and 2), an enzyme involved in the production of prostaglandins, messengers in the development of inflammation. Al…
Article
Vertigo/dizziness as a Drugs’ adverse reaction
Serafina Chimirri, Rossana Aiello, Carmela Mazzitello, Laura Mumoli, Caterina Palleria, Mariolina Altomonte, Rita Citraro, Giovambattista Sarro
pp. S104–S105 · DOI: 10.4103/0976-500X.120969 · Published 2013
Introduction: Vertigo, dizziness, and nausea encompass a spectrum of balance-related symptoms caused by a variety of etiologies. Balance is affected by many systems: Proprioceptive pathways and visual, cerebellar, vestib…

Mini Review

Article
Anti-vascular endothelial growth factor drugs safety and efficacy in ophthalmic diseases
Pasquale Ventrice, Christian Leporini, Jose’ Francisco Aloe, Ettore Greco, Giacomo Leuzzi, Giuseppina Marrazzo, Giovanni Battista Scorcia, Donatella Bruzzichesi, Varano Nicola, Vincenzo Scorcia
pp. S38–S39 · DOI: 10.4103/0976-500X.120947 · Published 2013
Macular degeneration is the leading cause of blindness in developed countries. In the treatment of neovascular age-related macular degeneration, vascular endothelial growth factor (VEGF) has emerged as a key target for t…

Research Article

Article
Retrospective evaluation of adverse drug reactions induced by antihypertensive treatment
Pierandrea Rende, Laura Paletta, Giuseppe Gallelli, Gianluca Raffaele, Vincenzo Natale, Nazareno Brissa, Cinzia Costa, Santo Gratteri, Chiara Giofrè, Luca Gallelli
pp. S47–S48 · DOI: 10.4103/0976-500X.120954 · Published 2013
The use of cardiovascular drugs is related to the development of adverse drug reactions (ADRs) in about 24% of the patients in the Cardiovascular Care Unit. Here, we evaluated the ADRs in patients treated with antihypert…
Article
A questionnaire-based study in Calabria on the knowledge of off-label drugs in pediatrics
Francesca Saullo, Ernesto Saullo, Mimma Caloiero, Michele Menniti, Claudia Carbone, Serafina Chimirri, Laura Paletta, Luca Gallelli
pp. S51–S52 · DOI: 10.4103/0976-500X.120960 · Published 2013
Off-label use is very common among pediatricians, and the main cause is attributable to the lack of drugs specifically designed and marketed for children in different age groups. In this study, we evaluated, through a qu…

Report

Article
Annual report on adverse events related with vaccines use in Calabria (Italy): 2012
Orietta Staltari, Felisa Cilurzo, Benedetto Caroleo, Alexia Greco, Francesco Corasaniti, Maria Antonietta Genovesi, Luca Gallelli
pp. S61–S62 · DOI: 10.4103/0976-500X.120951 · Published 2013
Vaccines are administered to large population of healthy individuals, particularly to millions of infants every year, through national immunization programs. Although vaccines represent a good defense against some infect…

Case Series

Article
Safety and efficacy of generic drugs with respect to brand formulation
Luca Gallelli, Caterina Palleria, Antonio Vuono, Laura Mumoli, Piero Vasapollo, Brunella Piro, Emilio Russo
pp. S110–S111 · DOI: 10.4103/0976-500X.120972 · Published 2013
Generic drugs are equivalent to the brand formulation if they have the same active substance, the same pharmaceutical form and the same therapeutic indications and a similar bioequivalence respect to the reference medici…