Intestinal pseudo‑obstruction following oral baclofen: An unusual complication
Vilvapathy Senguttuvan Karthikeyan1★, Kuppusamy Senthilkumaran1, Bettaiyagowder Easwaran1, Rajamariappan Rajbhaskar2★ Corresponding author
- 1Departments of General Surgery, College Hospital and Research Centre, Puducherry, India.
- 2Neurosurgery, Sri Venkateshwaraa Medical College Hospital and Research Centre, Puducherry, India.
CORRESPONDENCE
Vilvapathy Senguttuvan Karthikeyan
Departments of General Surgery, College Hospital and Research Centre, Puducherry, India.
Received: 06-07-2014; Revised: 26-09-2014; Accepted: 17-12-2014.
Volume 6, Issue 3 · pp. 169–171 · PUBLISHED 2015 · DOI: 10.4103/0976-500X.162010
ABSTRACT
Baclofen is a gamma- aminobutyric acid B (GABA B) agonist used for the management of spasticity associated with spinal cord injury. Oral baclofen might cause constipation, but intestinal pseudo‑obstruction is very rare. We report a 50‑year‑old male with spasticity following cervical discectomy (C3‑4) on oral baclofen for 6 months with intestinal pseudo-obstruction. He had undergone open suprapubic cystostomy for traumatic urethral injury, 45 days prior to the presentation and adhesive intestinal obstruction was also considered a possibility. However, there were no air fluid levels on abdominal radiographs and ultrasound abdomen was non‑contributory. Withdrawal of baclofen was therapeutic in this patient. This case is being reported to highlight the rare possibility of oral baclofen induced intestinal pseudo‑obstruction.
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Karthikeyan, V. S., Senthilkumaran, K., Easwaran, B., & Rajbhaskar, R. (2015). Intestinal pseudo‑obstruction following oral baclofen: An unusual complication. Journal of Pharmacology and Pharmacotherapeutics, 6(3), 169–171. https://doi.org/10.4103/0976-500X.162010