Volume 6, Issue 3

Editorial

1. Forum Article

   Are we moving towards a new definition of essential medicines?

   Manikandan S

   pp. 123–5 · DOI: 10.4103/0976-500X.162008 · Published 2015

   Essential medicines are defined as “those that satisfy the priority health care needs of the population,” with the concept being that they are intended to be available within the context of a functioning healthcare syste…

Review Article

1. Review

   Inhaled insulin: A “puff” than a “shot” before meals

   Dick B. S. Brashier, Anjan Khadka, Tejus Anantharamu, Ashok Kumar Sharma, A. K. Gupta

   pp. 126–129 · DOI: 10.4103/0976-500X.162013 · Published 2015

   Diabetes is a metabolic disorder characterized by relative or absolute deficiency of insulin, resulting in hyperglycemia. The main treatment of diabetes relies on subcutaneous insulin administration by injection or conti…

Research Paper

1. Article

   Comparison of anti-inflammatory effect of atorvastatin with rosuvastatin in patients of acute coronary syndrome

   Sushant Khurana, Surabhi Gupta, HiraLal Bhalla, Shefali Nandwani, Varad Gupta

   pp. 130–135 · DOI: 10.4103/0976-500X.162011 · Published 2015

   Objectives: To compare anti‑inflammatory effect of atorvastatin and rosuvastatin in patients of acute coronary syndrome. Materials and Methods: The study was a prospective, open‑labeled, randomized and single‑center stud…

2. Article

   Inhibition by sildenafil of contractility of isolated non‑pregnant human myometrium

   Aruldhas Blessed Winston, Kaysina Vazhudhi, Sumalya Sen, Elsy Thomas, Santhosh Benjamin

   pp. 136–141 · DOI: 10.4103/0976-500X.162020 · Published 2015

   Objective: To investigate the ability of sildenafil to inhibit the contractility of isolated non pregnant human myometrium. Materials and Methods: The inhibitory effect of three concentrations (3, 10, and 30 µM) of silde…

3. Article

   Effectiveness of vitamin D3 in severe persistent asthmatic patients: A double blind, randomized, clinical study

   Muhasaparur Ganesan Rajanandh, Arcot D. Nageswari, Giridharan Prathiksha

   pp. 142–146 · DOI: 10.4103/0976-500X.162022 · Published 2015

   Objective: To assess the pulmonary function and quality of life in asthma patients receiving vitamin D3 supplementation with inhaled budesonide and formoterol. Materials and Methods: This was a double blinded, randomized…

4. Article

   The effects of A2B receptor modulators on vascular endothelial growth factor and nitric oxide axis in chronic cyclosporine nephropathy

   Leena Patel, Aswin Thaker

   pp. 147–148 · DOI: 10.4103/0976-500X.162014 · Published 2015

   Introduction: To investigate the actions of adenosine A2B receptor modulators on VEGF and NO levels in CsA nephropathy. Materials and Methods: Nephropathy was induced by administrating 25 mg/kg (s.c) of CsA for 5 weeks. …

Research Letter

1. Article

   Identification and characterization of primate P-glycoprotein

   Mesfin Yimam

   pp. 154–6 · DOI: 10.4103/0976-500X.162021 · Published 2015

   Achieving the therapeutic goal of human immunodeficiency virus(HIV) infection is complex in nature due to the potential drug–drug interactions, modulations in the cytochrome P450 enzyme and/or drug transporters such as P…

Case Report

1. Article

   Double trouble: Cyclosporine‑induced thrombocytosis in a patient with methotrexate toxicity: Are they related?

   Cherukuri Tejaswi, Saritha Mohanan, Rangaraj Murugaiyan, Kaliaperumal Karthikeyan

   pp. 160–162 · DOI: 10.4103/0976-500X.162005 · Published 2015

   Psoriasis is a common, chronic, disfiguring, inflammatory, and proliferative condition of the skin. It manifests with varying degrees of severity and can be treated with various immune modulators. This is a case report o…

2. Article

   Exercise‑induced anaphylaxis and antileukotriene montelukast

   Sapna Gajbhiye, Rajendra Prasad Agrawal, Shubham Atal, Vikalp Tiwari, Pradeep Phadnis

   pp. 163–165 · DOI: 10.4103/0976-500X.162007 · Published 2015

   We report a rare case of exercise‑induced anaphylaxis (EIA), occurring exclusively with exercise, without any other associated trigger, detected in the prodromal phase, and prevented from additional anaphylaxis episodes …

3. Article

   Intestinal pseudo‑obstruction following oral baclofen: An unusual complication

   Vilvapathy Senguttuvan Karthikeyan, Kuppusamy Senthilkumaran, Bettaiyagowder Easwaran, Rajamariappan Rajbhaskar

   pp. 169–171 · DOI: 10.4103/0976-500X.162010 · Published 2015

   Baclofen is a gamma- aminobutyric acid B (GABA B) agonist used for the management of spasticity associated with spinal cord injury. Oral baclofen might cause constipation, but intestinal pseudo‑obstruction is very rare. …

4. Article

   Acalculous pyelonephritis and cholecystitis occurring simultaneously in a diabetic patient on sitagliptin therapy

   Jayaprakash Sahoo, Sadishkumar Kamalanathan, Muthupillai Vivekanandan, Rathinam Palamalai Swaminathan

   pp. 172–174 · DOI: 10.4103/0976-500X.162016 · Published 2015

   Dipeptidyl peptidase‑4 (DPP‑4) inhibitors are a new class of anti‑diabetic drugs. They control both fasting and postprandial hyperglycemia by inhibiting degradation of incretin hormones, such as, glucagon‑like peptide‑1(…

5. Article

   Complete resistance after maximal dose of rocuronium

   Annalisa Capuano, Maria Giuseppa Sullo, Concetta Rafaniello, Liberata Sportiello, Pierfrancesco Fusco, Macella De Vizia, Fausto Ferraro

   pp. 175–178 · DOI: 10.4103/0976-500X.162012 · Published 2015

   Rocuronium is a non‑depolarizing neuromuscular blocking agent (NDNMBA), employed in the clinic as an adjunct to general anesthesia to facilitate tracheal intubation rapid sequence, and to provide skeletal muscle relaxati…

6. Article

   Life‑threatening bradyarrhythmia with oral phenytoin overdose

   Giridharan Srinivasan, Mukta Wyawahare, Pratheesh George Mathen, Dharanipragada K.

   pp. 179–181 · DOI: 10.4103/0976-500X.162017 · Published 2015

   We report a case of a 41‑year‑old lady, who developed severe hypotension and sinus bradycardia, following oral consumption of 20 g of phenytoin and 500 mg of glibenclamide. She required high dose of inotropes and a tempo…

Webwise

1. Article

   International conference on harmonization of technical requirements for registration of pharmaceuticals for human use

   Jatinder Singh

   pp. 185–187 · DOI: 10.4103/0976-500X.162004 · Published 2015

1. Article

   Naloxegol: First oral peripherally acting mu opioid receptor antagonists for opioid-induced constipation

   Tejus Anantharamu, Sushil Sharma, Ajay Kumar Gupta, Navdeep Dahiya, Dick B. Singh Brashier

   pp. 188–192 · DOI: 10.4103/0976-500X.162015 · Published 2015

   Opioid‑induced constipation (OIC) is one of the most troublesome and the most common effects of opioid use leading to deterioration in quality of life of the patients and also has potentially deleterious repercussions on…

Erratum

1. Article

   Stevens-Johnson syndrome caused by Cefepime: Erratum

   pp. 193–193 · DOI: 10.4103/0976-500X.162023 · Published 2015