Treatment Outcome of Ovulation‑inducing Agents in Patients with Anovulatory Infertility: A Prospective, Observational Study
Kinjal Prajapati1★, Mira Desai1, Samidh Shah1, Sumesh Choudhary2, Rohina Aggarwal2, Vineet Mishra2★ Corresponding author
- 1Department of Pharmacology, B.J. Medical College, India.
- 2Department of Obstetrics and Gynaecology, Institute of Kidney Diseases and Research Center, Civil Hospital, Ahmedabad, Gujarat, India.
CORRESPONDENCE
Kinjal Prajapati
Department of Pharmacology, B.J. Medical College, India.
Received: 20-03-2017; Revised: 17-06-2017; Accepted: 24-07-2017.
Volume 8, Issue 3 · pp. 116–121 · PUBLISHED 2017 · DOI: 10.4103/jpp.JPP_43_17
ABSTRACT
Objective: To compare different treatment regimens on pregnancy rate and outcome in patients with anovulatory infertility. Patients and Methods: A prospective observational study was conducted on patients with infertility due to anovulation. Patients treated with clomiphene citrate (CC) 50/100 mg/day from 2nd to 6th day of menstrual cycle (MC) (n = 38), short gonadotropin‑releasing hormone (GnRH) agonist regimen (leuprolide [0.5 mg subcutaneous] + recombinant follicle‑stimulating hormone [rFSH] [225 IU intramuscular [IM]] from 2nd to 10th day of MC [n = 32]), long GnRH agonist regimen (leuprolide from 21st day followed by leuprolide + rFSH from 2nd to 10th day of MC [n = 19]), and antagonist regimen (human menopausal gonadotropin [hMG] [150 IU IM] from 2nd day followed by hMG + cetrorelix from 7th to 10th day of MC) (n = 6) were recruited and followed up for follicular size, endometrial thickness, and pregnancy test. Data were analyzed using appropriate statistical test and P < 0.05 was considered statistically significant. Results: A significant increase in follicular diameter and endometrial thickness was observed in patients treated with gonadotropin regimens as compared to CC alone (P < 0.0001). The highest number of positive pregnancy test with ultrasonographic evidence of gestational sac was observed with leuprolide + rFSH (long regimen) (10/19, 52.6%) followed by leuprolide + rFSH (short regimen) (13/32, 40.6%) while least in antagonist regimen (2/6, 33.3%) and CC (1/38, 2.63%). All regimens were well tolerated. Conclusion: Treatment outcome was better with long agonist regimen.
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Prajapati, K., Desai, M., Shah, S., Choudhary, S., Aggarwal, R., & Mishra, V. (2017). Treatment Outcome of Ovulation‑inducing Agents in Patients with Anovulatory Infertility: A Prospective, Observational Study. Journal of Pharmacology and Pharmacotherapeutics, 8(3), 116–121. https://doi.org/10.4103/jpp.JPP_43_17