Volume 8, Issue 3

An Overview of the Extraarticular Involvement in Rheumatoid Arthritis and its Management

Subham Das, Prasanta Padhan

pp. 81–86 · DOI: 10.4103/jpp.JPP_194_16 · Published 2017

Rheumatoid arthritis (RA) is an autoimmune systemic disease characterized by long‑standing inflammation and significant joint destruction. Despite significant research and success toward the treatment modalities, complet…

Retrospection on the Role of Soluble Guanylate Cyclase in Parkinson’s Disease

Mohankrishna Ghanta, Elango Panchanathan, Bhaskar V. K. S. Lakkakula, Anbumani Narayanaswamy

pp. 87–91 · DOI: 10.4103/jpp.JPP_45_17 · Published 1 July 2017

Soluble guanylate cyclase (sGC) is an important transducing enzyme of cyclic guanosine monophosphate (cGMP) signaling pathway in striatum which has been considered as a potential target for the treatment of Parkinson’s d…

Biological Response Modifiers in Rheumatoid Arthritis: Systematic Review and Meta‑analysis of Safety

Nitishkumar D. Tank, Bharti N. Karelia, Bhavisha N. Vegada

pp. 92–105 · DOI: 10.4103/jpp.JPP_155_16 · Published 2017

Objective: To analyze available evidence on the safety of different biological response modifiers which are used for a treatment of rheumatoid arthritis (RA). Materials and Methods: We searched systematically for randomi…

Efficacy and Tolerability of Olmesartan, Telmisartan, and Losartan in Patients of Stage I Hypertension: A Randomized, Open‑label Study

Mrunalini Kalikar, Kundan S. Nivangune, Ganesh N. Dakhale, Chaitali S. Bajait, Smita D. Sontakke, Vijay M. Motghare, Ritu Budania

pp. 106–111 · DOI: 10.4103/jpp.JPP_39_17 · Published 2017

Objectives: To compare the efficacy and tolerability of losartan, telmisartan, and olmesartan as antihypertensive agents and evaluate and compare their effects on lipid profile and blood glucose. Materials and Methods: T…

Effect of Lorazepam in Reducing Psychological Distress and Anticipatory Nausea and Vomiting in Patients Undergoing Chemotherapy

Aloysius James, Malini Muraleedharan Nair, Dhanya Susan Abraham, Joel Sunny Kovoor, Wesley M. Jose, Remya Reghu

pp. 112–5 · DOI: 10.4103/jpp.JPP_54_17 · Published 2017

Objectives: To evaluate the efficacy and safety of lorazepam in reducing psychological distress and chemotherapy‑induced nausea and vomiting. Methodology: It was a prospective interventional study with seventy patients f…

Treatment Outcome of Ovulation‑inducing Agents in Patients with Anovulatory Infertility: A Prospective, Observational Study

Kinjal Prajapati, Mira Desai, Samidh Shah, Sumesh Choudhary, Rohina Aggarwal, Vineet Mishra

pp. 116–121 · DOI: 10.4103/jpp.JPP_43_17 · Published 2017

Objective: To compare different treatment regimens on pregnancy rate and outcome in patients with anovulatory infertility. Patients and Methods: A prospective observational study was conducted on patients with infertilit…

Cardioprotective Effect of Coenzyme Q10 on Apoptotic Myocardial Cell Death by Regulation of Bcl‑2 Gene Expression

Najam Ali Khan, M. Abid, Aftab Ahmad, Mohammed F. Abuzinadah, Mohammed Basheikh, Kamal Kishore

pp. 122–127 · DOI: 10.4103/jpp.JPP_47_17 · Published 2017

Objectives: To investigate the effect of coenzyme Q10 (CoQ10) on apoptotic myocardial cell death in rat model of heart ischemia and reperfusion I/R injury. Materials and Methods: Eighteen rats (200–250 g) were divided in…

Penetration of Bromelain in Serum and Rhinosinusal Mucosa in Patients Undergoing Endoscopic Sinus Surgery

Desiderio Passali, Luisa Maria Bellussi, Codrut Sarafoleanu, Michele Loglisci, Claudiu Manea, Cristina Iosif, Francesco Maria Passali

pp. 128–9 · DOI: 10.4103/jpp.JPP_169_16 · Published 1 July 2017

The objective of our research was to find the concentration of bromelain in rhinosinusal mucosa of patients with chronic rhinosinusitis (Group A) and of individuals without nasal or paranasal diseases (Group B). Forty pa…

The Basis for Low-affinity hERG Potassium Channel Block by Sotalol

Yi Hong Zhang, Christopher E. Dempsey, Jules C. Hancox

pp. 130–131 · DOI: 10.4103/jpp.JPP_69_17 · Published 2017

The human Ether-à-go-go-Related Gene (hERG) encodes potassium channels mediating the rapid delayed-rectifier K+ current, IKr, which is crucial for normal repolarization of the ventricles of the heart. hERG is established…

Cardiac Safety of High-dose Micafungin

Kayla R. Stover, John D. Cleary

pp. 132–133 · DOI: 10.4103/jpp.JPP_37_17 · Published 2017

Pharmacotherapy in patients with systemic fungal infections continues to challenge the heartiest clinicians. The inability of the antimycotic to discriminate the infected eukaryotic host from the pathogen often leads to …

Why the Jan Aushadhi Scheme Has Lost Its Steam in India?

Vijay Thawani, Abin Mani, Neeraj Upmanyu

pp. 134–6 · DOI: 10.4103/jpp.JPP_38_17 · Published 2017

The Jan Aushadhi Scheme (JAS) initiated by the Government of India is a powerful intervention against the unjustifiable pricing of medicines by private pharmaceutical industry, to make the generic medicines available at …

Sodium Glucose Transporter 2 Inhibitors and Diabetic Ketoacidosis in Three Patients with Diabetes: Underlying Causation

Jordan L. Kelley, Matthew Strum, Daniel M. Riche, Andrew M. Chandler

pp. 137–9 · DOI: 10.4103/jpp.JPP_20_17 · Published 2017

Sodium glucose transporter 2 inhibitors (SGLT2i) inhibit the reabsorption of glucose in the renal tubules reducing glycemia and increasing glucosuria. The increased glucosuria causes a shift in normal flora and colonizat…

Ceftriaxone for the Treatment of Methicillin-susceptible Staphylococcus aureus Bacteremia: A Case Series

Rachel Amanda Lowe, Katie Elizabeth Barber, Jamie Leigh Wagner, Allison Miriam Bell-Harlan, Kayla Renay Stover

pp. 140–4 · DOI: 10.4103/jpp.JPP_5_17 · Published 2017

Methicillin-susceptible Staphylococcus aureus (MSSA) causes 45% of S. aureus bloodstream infections (BSI) and is the most important cause of BSI-associated death. The standard of care therapy is an anti-staphylococcal pe…

Looking beyond the Obvious: Cefepime-induced Nonconvulsive Status Epilepticus

Vinayaka Anuhya, Sushil Kiran Kunder, Sharath Madhyastha, Veena Nayak, Raviraja V. Acharya, Kusugodlu Ramamoorthi, Avinash Arivazhahan, Rahul Sai Gangula

pp. 145–147 · DOI: 10.4103/jpp.JPP_64_17 · Published 2017

Cephalosporins are a commonly used class of antibiotics in various types of infections. Cefepime, a fourth-generation cephalosporin, has been reported to cause neurotoxicity, which can present itself as varied manifestat…

Terlipressin-induced Peripheral Ischemic Gangrene in a Diabetic Patient

Phulen Sarma, Gaurav Muktesh, Narender Dhaka, Rakesh Ruhela, Abhishek Mishra, Rahul Singh, Saroj K. Sinha, Bikash Medhi, Rakesh Kochhar

pp. 148–150 · DOI: 10.4103/jpp.JPP_42_17 · Published 2017

Terlipressin is used commonly in the management of hepatorenal syndrome and acute variceal bleeding. Like its parent compound vasopressin, it is also notorious for its ischemic complications. Terlipressin-induced ischemi…

A Giant of Indian Pharmacology is No More: Rest in Peace Prof. B. N. Dhawan

Syed Ziaur Rahman

pp. 151–2 · DOI: 10.4103/jpp.JPP_105_17 · Published 2017

Erratum: Blood Sample Collection in Small Laboratory Animals

pp. 153–153 · DOI: 10.4103/0976-500X.215702 · Published 2017