Volume 5, Issue 3

Antidepressant‑like effect of a novel 5‑HT3 receptor antagonist N‑(benzo[d] thiazol‑2‑yl)‑3‑ethoxyquinoxalin‑2‑carboxamide 6k using rodents behavioral battery tests

Yeshwant Kurhe, Radhakrishnan Mahesh, Thangaraj Devadoss, Deepali Gupta

pp. 122–123 · DOI: 10.4103/0976-500X.136104 · Published 2010

Objective: To investigate the antidepressant‑like effect of N‑(benzo[d] thiazol‑2‑yl)‑3‑ ethoxyquinoxalin‑2‑carboxamide 6k, a 5‑hydroxytryptamine type 3 (5‑HT3) receptor antagonist using rodents behavioral battery tests.…

Effects of glucocorticoids and tumor necrosis factor‑alpha inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis

Raffaele Serra, Raffaele Grande, Gianluca Buffone, Edoardo Scarcello, Fabio Tripodi, Pierandrea Rende, Luca Gallelli, Stefano de Franciscis

pp. 193–196 · DOI: 10.4103/0976-500X.136101 · Published 2014

Objective: To explore the effect of sequential treatment with glucocorticoid and tumor necrosis factor‑alpha inhibitors in patients with Takayasu arteritis (TA). Materials and Methods: In five patients with TA, the effec…

[Downloaded free from http://www.jpharmacol.com on Wednesday, October 13, 2021, IP: 157.45.222.78]

Raveendran: Animal experimentation in postgraduate training Journal of Pharmacology and Pharmacotherapeutics | July-September | Vol | Issue

pp. 179–180 · DOI: 10.4103/0976-500X.136095 · Published 2014

The article with the headline “Medical Council of India (MCI) likely to ban animal dissection at post‑grad level too” in the Pioneer, a New Delhi based daily came as a rude shock to some of us (http://www.dailypioneer.co…

Statin induced diabetes and its clinical implications

Umme Aiman, Ahmad Najmi, Rahat Ali Khan

pp. 181–185 · DOI: 10.4103/0976-500X.136097 · Published 2014

Statins are one of the most commonly used drugs in the world based on their potential to prevent adverse cardiovascular events. These cholesterol‑lowering drugs received a US Food and Drug Administration warning, in Febr…

Metronomic chemotherapy

Rituparna Maiti

pp. 186–192 · DOI: 10.4103/0976-500X.136098 · Published 2014

Toxic effects and chemoresistance are major hurdles in chemotherapy and to avoid these problems caused by traditional chemotherapeutic regimens, a new modality of drug administration called “metronomic chemotherapy” has …

Cannabis use among opioid-dependent individuals on opioid substitution therapy

Yatan Pal Singh Balhara, Raka Jain

pp. 203–205 · DOI: 10.4103/0976-500X.136106 · Published 2014

The findings of this study suggest that a significant proportion of individuals on OST tested positive for cannabis. It is therefore recommended to use urinalysis during OST to monitor ongoing use of cannabis. Detection …

Sexual dysfunction in alcohol-dependent men on disulfiram or baclofen prophylaxis: A preliminary report

Sandeep Grover, Siddharth Sarkar, Naresh Nebhinani, Surendra K. Mattoo, Debasish Basu

pp. 205–207 · DOI: 10.4103/0976-500X.136108 · Published 2014

The alcohol use disorders and sexual functioning have a complex relationship. Alcohol use has been suggested to enhance desire of sexual activity and indulgence in riskier sex. Use of alcohol has also been linked with im…

Hirsutism following the use of bimatoprost eyedrops for glaucoma

Subashini Kaliaperumal, Indu Govindaraj, Praveen Kumar Kopparapu, Shashi Ahuja

pp. 208–210 · DOI: 10.4103/0976-500X.136110 · Published 2014

Prostaglandin F2 alpha (PGF2α) analogues including bimatoprost are often the first line drugs used in the treatment of glaucoma. We present a case of a 62‑year‑old female patient who was started on bimatoprost in both th…

Netilmicin‑induced carpopedal spasm

Roja Y. Ramani, Benu Panigrahy, Bandana Rath

pp. 211–213 · DOI: 10.4103/0976-500X.136112 · Published 2014

Aminoglycoside‑induced nephrotoxicity is not uncommon. Netilmicin being a member of gentamicin family has the advantage of being relatively free from ototoxicity and nephrotoxicity and is also prescribed for gentamicin r…

Angioedema due to fixed dose combination of telmisartan plus ramipril

Vishal R. Tandon, Annil Mahajan, Vijay Khajuria, Zahid H. Gillani

pp. 214–216 · DOI: 10.4103/0976-500X.136113 · Published 2014

The risk for angioedema has been suggested lower with angiotensin receptor blockers (ARBs) than with angiotensin‑converting enzyme inhibitors (ACEIs) or aliskiren. Many isolated reports do exist, reporting angioedema wit…

Acute delirium in an elderly woman following zoledronate administration

Mohammad Nasiruddin, Mohd Fayazuddin, Mohammad Zahid, Syed Iftekhar

pp. 217–219 · DOI: 10.4103/0976-500X.136115 · Published 2014

Zoledronate is a third‑generation bisphosphonate having distinctive profile of high potency as well as prolonged duration of action. Intravenous zoledronate is the recently approved bisphosphonate for the treatment of os…

New(s): Are these terms new(s)!?

G. Sivagnanam

pp. 220–221 · DOI: 10.4103/0976-500X.136116 · Published 2014

News and review

pp. 220–220 · DOI: · Published 2014

The Trial to Assess Chelation Therapy (TACT) was a study (a 10‑year, $31.6‑million study involving 1,708 participants at 134 centers) that involved an intervention of EDTA‑based infusion regimen in patients aged ≥50 year…

Delamanid: A new armor in combating drug‑resistant tuberculosis

Alphienes Stanley Xavier, Mageshwaran Lakshmanan

pp. 222–224 · DOI: 10.4103/0976-500X.136121 · Published 2014

Intense search has been made in the discovery of newer anti‑TB drugs to tackle the issues such as drug resistance, HIV co‑infection and risk of drug‑drug interactions in the management of TB. Delamanid, a newer mycobacte…