Cover: Journal of Pharmacology and Pharmacotherapeutics
Journal of Pharmacology and Pharmacotherapeutics
Volume 5, Issue 4
2014 · pp. 225–284 · 18 articles
- Volume
- 5
- Issue
- 4
- Published
- 2014
- Pages
- 225–284
- Articles
- 18
- Sections
- 9
- ISSN
- Print - 0976-500X, Online - 0976-5018
- Journal
- JPP
In this issue
Editorial
- Forum Article
Push, promote or educate…musings of a pharmacologist on drug promotion
Chanolean Shashindran
pp. 225–226 · DOI: 10.4103/0976-500X.142427 · Published 2014
A recent NDTV programme aired on national television created a lot of angst among those in the medical profession.[1] Here was another instance of the profession being shown in a bad light, due to the dealings of a few u…
Review Article
- Review
Management of diabetes in the elderly with canagliflozin: A newer hypoglycemic drug on the horizon
Vishal Sehgal, Sukhminder Jit Singh Bajwa, Rinku Sehgal, John A Consalvo
pp. 227–231 · DOI: 10.4103/0976-500X.142428 · Published 2014
Canagliflozin is the first available oral inhibitor of sodium/glucose cotransporter 2 (SGLT2) in the market. At the outset it sounds excellent for the use in the elderly diabetic population, because of its minimal tenden…
Research Paper
- Article
Acetylated and propionated derivatives of swertiamarin have anti‑adipogenic effects
Hitesh B Vaidya, Ramesh K Goyal, Sukhinder K Cheema
pp. 232–238 · DOI: 10.4103/0976-500X.142429 · Published 2014
Objective: To investigate whether the acetylated and propionated derivatives (LMP‑09‑1 and ‑2) of swertiamarin have anti‑adipogenic effects. Materials and Methods: 3T3‑L1 pre‑adipocytes were grown in Dulbecco’s Modified …
- Article
Oral carvedilol in escalating doses in the acute treatment of atrial fibrillation
Ravi Venkatachelam Chitrapu, Pentakota Ramana Rao, Gangireddy Venkateswara Reddy
pp. 239–244 · DOI: 10.4103/0976-500X.142430 · Published 2014
Objective: To study the efficacy of oral carvedilol in acute treatment of atrial fibrillation (AF) with fast ventricular rate. Materials and Methods: In an open‑label, single‑arm trial, oral carvedilol was administered t…
Correspondence
- Article
The impact of irrational practices: A wake up call
Meena Garg, Pinki Vishwakarma, Monica Sharma, Rajiv Nehra, K. K. Saxena
pp. 245–247 · DOI: 10.4103/0976-500X.142434 · Published 2014
Our study included 92 randomly selected prescriptions from allopathic registered medical practitioners between September 2011 and October 2012. These were analyzed for content and format. The number of non‑sponsored CMEs…
Research Letter
- Article
Pharmacovigilance and adverse drug reaction reporting perspectives among interns and postgraduates of a teaching hospital
Raghava Sharma, Adithi Kellarai
pp. 248–250 · DOI: 10.4103/0976-500X.142436 · Published 1 December 2014
Pharmacovigilance (PV) is the branch dealing with adverse drug reactions (ADRs), their recognition, and reporting. ADR is defined by the World Health Organization (WHO) as a response to a drug that is noxious, unintended…
- Article
Evaluation of potassium clavulanate on ethanol consumption and decision making in the model of ethanol dependence in mice
Kshitij S. Jadhav, Padmaja A. Marathe
pp. 250–252 · DOI: 10.4103/0976-500X.142439 · Published 2014
Glutamate increases dopamine levels in the nucleus accumbens leading to ethanol dependence. Since glutamate transporter 1 (GLT1) is responsible for the removal of synaptic glutamate, up-regulation of GLT1 attenuates etha…
- Article
Antimicrobial utilization in multidisciplinary intensive care units of a public tertiary care hospital
Gudapati Bhanu Naga Sireesha, Pramil Tiwari, Satinder Gombar, Sanjay D’Cruz, Atul Sachdev
pp. 252–254 · DOI: 10.4103/0976-500X.142441 · Published 2014
This 3‑month observational study was carried out at the ICUs of a public tertiary care hospital. ICUs with 14 bed capacity handle all patients who require ICU level care. Only patients with >24 h of ICU stay and who were…
- Article
Pediatric dosing errors due to variable drug formulations
Sumit Mehndiratta
pp. 254–255 · DOI: 10.4103/0976-500X.142444 · Published 2014
Dosing errors are not uncommon in day-to-day clinical practice in children. Pediatric patients are more vulnerable to adverse drug events because of small body size and need for weight based dosing. Among various reasons…
Case Report
- Article
Oyster shell calcium induced parotid swelling
Muthiah Palaniappan, Sandhiya Selvarajan, Sureshkumar Srinivasamurthy, Adithan Chandrasekaran
pp. 256–257 · DOI: 10.4103/0976-500X.142446 · Published 2014
A 59 year old female consumer was started on therapy with oyster shell calcium in combination with vitamin D3 and she presented with swelling below the ear, after two doses. She stopped the drug by herself and the swelli…
- Article
Risperidone‑induced mania: An emergent complication of treatment
Anjana Rao Kavoor, Sayantanava Mitra, Supriya Kumar Mondal, Basudeb Das
pp. 258–260 · DOI: 10.4103/0976-500X.142448 · Published 2014
The occurrence of manic/hypomanic switch in patients being treated with risperidone has been reported by various authors, and they have described a variety of strategies for their management. In this report, we describe …
- Article
Catatonia in mixed alcohol and benzodiazepine withdrawal
Aniruddha Basu, Amit Jagtiani, Rajiv Gupta
pp. 261–264 · DOI: 10.4103/0976-500X.142449 · Published 2014
Catatonia is mostly caused by different neuropsychiatric conditions. We report a case of a 30 year old man suffering from both alcohol and benzodiazepine dependence who exhibited catatonic features soon after stopping th…
- Article
Ganciclovir–tenofovir interaction leading to tenofovir‑induced nephrotoxicity
Radhika Soanker, Shobha Jagdish Chandra Udutha, Malladi V S Subbalaxmi, YSN Raju
pp. 265–267 · DOI: 10.4103/0976-500X.142452 · Published 2014
Viral enteritis is an important gastrointestinal disorder in human immunodeficiency virus (HIV)‑infected patients. Cytomegalovirus (CMV) is the most common opportunistic agent in these patients. As ganciclovir and tenofo…
- Article
Leukocytoclastic vasculitis and acute allergic interstitial nephritis following ceftriaxone exposure
Sachin R. Agrawal, Atul Rajput, A. P. Jain
pp. 268–270 · DOI: 10.4103/0976-500X.142453 · Published 2014
Leukocytoclastic vasculitis (LCV), also known as hypersensitivity vasculitis is a small vessel inflammatory disease which mainly involves the postcapillary venules. A 17‑year‑old girl developed palpable purpura over lowe…
- Article
Cutaneous adverse drug reaction type erythema multiforme major induced by eslicarbazepine
Andreu Massot, Ana Gimenez-Arnau
pp. 271–274 · DOI: 10.4103/0976-500X.142456 · Published 2014
Severe skin reactions occur less frequently with eslicarbazepine (ESL) than with the other aromatic anticonvulsants. We report the first case of cutaneous adverse drug reaction (CADR) to ESL and co‑sensitization between …
News and Views
- Article
Acetaminophen associated with risk of hearing loss: A safety alert
Sangeeta Bhanwra, Kaza Ahluwalia
pp. 275–275 · DOI: 10.4103/0976-500X.142458 · Published 2014
There has been recent news of association between acetaminophen and risk of hearing loss. Does it raise the bar of safety against indiscriminate use of the drug? National Institute of Health (NIH), USA, funded two prospe…
Mini Manuscript
- Article
Mini Manuscript
Jatinder Singh
pp. 276–7 · DOI: 10.4103/0976-500X.142462 · Published 2014
Dr. Anna Remington and Jake Fairnie, cognitive neuroscientists, chose to bridge the gap between the easy availability of literature and the lack of time and resources by harnessing the power of the internet by developing…
Molecules of the Millennium
- Article
Sofosbuvir: A novel treatment option for chronic hepatitis C infection
Harmeet Kaur Bhatia, Harmanjit Singh, Nipunjot Grewal, Navreet Kaur Natt
pp. 278–284 · DOI: 10.4103/0976-500X.142464 · Published 2014
Hepatitis C currently infects more than 170 million people around the world, leading to significant morbidity and mortality. The current standard of care for HCV infection, including one of the two protease inhibitors, t…