Volume 9, Issue 2

Supplementary Protection Certificates are Detrimental to Medicine Affordability

Vijay Thawani

pp. 63–65 · DOI: 10.4103/jpp.JPP_68_18 · Published 2018

The cost for development of a single drug is estimated between $350 million and $5.5 billion depending upon the product range of the company. According to the Tufts Center for the Study of Drug Development, the cost of d…

Comprehensive Review on Methadone-Induced QT Prolongation and Torsades

Jennifer M Treece, Mohammad Madani, George Khoury, Ola Khraisha, James E Martin, Steven J Baumrucker, Christopher A Neglia, Timir K Paul

pp. 66–75 · DOI: 10.4103/jpp.JPP_163_17 · Published 2018

An alternative analgesic to morphine is methadone, which is used to control chronic pain and is used in opioid rehabilitation treatment programs due to methadone having a long half-life and being relatively inexpensive a…

Terlipressin-Induced Ischemic Complications: A Systematic Review of Published Case Reports

Phulen Sarma, Gaurav Muktesh, Rahul Solomon Singh, Abhishek Mishra, Ashutosh Singh, Rakesh Kumar Ruhela, Harish Kumar, Narendra Dhaka, Bikash Medhi

pp. 76–85 · DOI: 10.4103/jpp.JPP_23_18 · Published 2018

Terlipressin is used in the management of variceal bleeding and hepatorenal syndrome. Ischemic complications are rare, but serious adverse effects of terlipressin therapy can be fatal. In this context, we reviewed all th…

Frequency of Chemotherapy Medication Errors: A Systematic Review

Ramkumar Ashokkumar, Sureshkumar Srinivasamurthy, Janet J. Kelly, Scott C. Howard, Subramani Parasuraman, Chakradhara Rao S. Uppugunduri

pp. 86–91 · DOI: 10.4103/jpp.JPP_61_18 · Published 2018

Objective: To synthesize peer‑reviewed knowledge on the frequency of different types of chemotherapy medication errors. Methods: The data were collected from studies published between January 1, 2000, and March 3, 2018, …

Investigation of hERG1b Influence on hERG Channel Pharmacology at Physiological Temperature

Aziza El Harchi, Dario Melgari, Henggui Zhang, Jules C. Hancox

pp. 92–103 · DOI: 10.4103/jpp.JPP_158_17 · Published 2018

Objective: To compare the inhibitory potencies of selected drugs (chloroquine, fluoxetine, cisapride, and ebastine [EBA]) on human Ether‑a‑go‑go‑Related Gene (hERG) potassium channel current carried by either hERG1a or c…

Adverse Drug Reactions at an Addiction Psychiatry Center: A Cross‑sectional Analysis

Siddharth Sarkar, Rakesh K. Chadda, Anusha Thota, Naveen Kumar Dhagudu, Thota Prasad

pp. 104–108 · DOI: 10.4103/jpp.JPP_41_18 · Published 2018

Objective: To perform a cross sectional analysis of anticipated and unanticipated adverse drug reactions occurring at an addiction psychiatry center. Materials and Methods: This observational analysis presents data on th…

Tumor Necrosis Factor-Alpha − 308 Gene Polymorphism in the Association between Gestational Diabetes Mellitus and Chronic Periodontitis in South Indian Population

Dhayanand John Victor, Sangeetha Subramanian, Prakash Ponnudurai Samuel Gnana, Bob Jacob Joseph

pp. 109–12 · DOI: 10.4103/jpp.JPP_45_18 · Published 2018

Objective: To investigate if tumor necrosis factor‑alpha (TNF‑α) G308A polymorphism influences the association between generalized chronic periodontitis (GCP) and gestational diabetes mellitus (GDM) in South Indian popul…

Impact of Educational Intervention on the Awareness of Disposal of Leftover/Expired Medicines among Health care Professionals

Manoj Goyal, Monika Bansal, Anurag Bajpai, Aboobecker Siddique, R. K. Srivastava

pp. 113–114 · DOI: · Published 2018

Dapsone-Induced Methemoglobinemia: Blue Cures Blue

Basil Jose, Josephine Valsa Jose, Mobin Paul

pp. 117–20 · DOI: 10.4103/jpp.JPP_16_18 · Published 2018

Dapsone, a sulfone group antibiotic, was traditionally used for the treatment of leprosy. It has potent anti-inflammatory and immunosuppressive properties. Hence later, its use has been expanded to conditions such as acn…