Volume 9, Issue 1

The Blood Blues: A Review on Methemoglobinemia

Sheba Rani David, Nora Syahirah Sawal, Muhammad Nur Salam Bin Hamzah, Rajan Rajabalaya

pp. 1–5 · DOI: 10.4103/jpp.JPP_79_17 · Published 2018

Methemoglobinemia is a blood disorder in which there is an abnormal amount of methemoglobin (MetHb) formation, thus unable to release oxygen effectively to body tissues. This is mainly because MetHb is the altered state …

Drug Approval in India Does not Match the Disease Burden: A Cross‑sectional Study

Jaykaran Charan, Jatin V. Dhanani, Maulik Sumantbhai Doshi, Tea Reljic, Athanasios Tsalatsanis, Ambuj Kumar

pp. 6–10 · DOI: 10.4103/jpp.JPP_168_17 · Published 2018

Objectives: To assess the correlation between drug approval and disease burden in India. Materials and Methods: A cross sectional study was conducted and data on drug approval for the past 14 years (2000–2013) were downl…

Valproic Acid Reduces Tumor Cell Survival and Proliferation with Inhibitors of Downstream Molecules of Epidermal Growth Factor Receptor Pathway

Bhuvanesh Sukhlal Kalal, Vinitha Ramanath Pai, Dinesh Upadhya

pp. 11–6 · DOI: 10.4103/jpp.JPP_129_17 · Published 2018

Objectives: To evaluate the beneficial effect of treating tumor cells with valproic acid (VPA) in combination with inhibitors of various downstream molecules of epidermal growth factor receptor pathway for limiting tumor…

Effect of Etoksidol Against Sulfur-Containing Gas Induced Reduction in Bone Marrow Microcirculation in Different Stages of Ontogenesis in Rats

Olga A. Ovsyannikova

pp. 17–20 · DOI: 10.4103/jpp.JPP_196_16 · Published 2018

Objective: To investigate the state of femoral red bone marrow microvasculature of nonlinear white male rats in the course of an acute experiment. Materials and Methods: The ontogenesis of experimental animals were betwe…

Effect of Coexisting Hypertension, Blood Pressure Control, and Antihypertensive Treatment on QT Interval Parameters in Type 2 Diabetics: A Cross‑Sectional Study

Jayesh Dalpatbhai Solanki, Kruti J. Patel, Nisha Lalwani, Hemant B. Mehta, Chinmay J. Shah, Matika N. Lakhtaria

pp. 21–26 · DOI: 10.4103/jpp.JPP_139_17 · Published 2018

Objectives: To study the electrocardiogram (ECG) based QT parameters namely QTc (heart rate corrected QT), QTd (QT dispersion) in treated type 2 diabetics (T2D) and the effect of hypertension (HTN), blood pressure (BP) c…

Efficacy and Safety of Nadifloxacin and Benzoyl Peroxide versus Adapalene and Benzoyl Peroxide in Acne Vulgaris: A Randomized Open‑label Phase IV Clinical Trial

Arijit Ghosh, Kapildev Das

pp. 27–31 · DOI: 10.4103/jpp.JPP_20_18 · Published 2018

Objective: To compare the efficacy and safety of nadifloxacin and benzoyl peroxide versus adapalene and benzoyl peroxide in acne vulgaris. Materials and Methods: Patients fulfilling the inclusion criteria were divided in…

Therapeutic Effect of Fibroblast Growth Factor and Olfactory Ensheathing Cells in Rat Models of Spinal Cord Injury

Durai Murugan Muniswami, Bashir Ahmed, George Tharion

pp. 32–39 · DOI: 10.4103/jpp.JPP_173_17 · Published 2018

Objective: To compare the efficacy of individual and combined treatment of olfactory ensheathing cells (OECs) and acidic fibroblast growth factor (aFGF) in a rat model of spinal cord injury (SCI). Materials and Methods: …

Does Mirtazapine Withdrawal Induces Mania or Not?

Kamaldeep Sadh, Pooja Shatadal, Ekta Franscina Pinto, Sachin Nagendrappa, Harish M. Tharayil, Chittaranjan Andrade

pp. 42–42 · DOI: 10.4103/jpp.JPP_27_18 · Published 2018

Oseltamivir-induced Neuropsychiatric Symptoms

Arshad Basha Shaik, Mukhyaprana Prabhu, Smita Shenoy, Sereen Rose Thomson

pp. 43–5 · DOI: 10.4103/jpp.JPP_121_17 · Published 2018

Oseltamivir is a viral neuraminidase enzyme inhibitor commonly prescribed for prevention and management of influenza. Common adverse effects of oseltamivir are gastrointestinal side effects such as nausea, vomiting, diar…

Toxic Epidermal Necrolysis versus Staphylococcal Scalded Skin Syndrome: A Diagnostic Confusion in a 2-year-old Child with Ceftriaxone Therapy

Vybhava Krishna, Sadhana N. Holla, Sweenly V. Sunny, Srikiran A. Hebbar

pp. 46–8 · DOI: 10.4103/jpp.JPP_152_17 · Published 1 January 2018

Toxic epidermal necrolysis (TEN) is a rare, but serious condition characterized by widespread death of epidermis involving skin and mucous membrane. Ceftriaxone‑induced TEN in the pediatric age group is rare. Hereby, we …

Need of the Hour: Warfarin-induced Massive Intraperitoneal Bleed

Vinayaka Anuhya, Sharath Madhyastha, Veena Nayak, Gangaparameswari Soundarrajan, Raviraj Acharya

pp. 49–51 · DOI: 10.4103/jpp.JPP_151_17 · Published 2018

Warfarin is an oral anticoagulant which is a natural coumarin derivative used for the treatment of various diseases such as thromboembolic disorders, prosthetic heart valves, and atrial fibrillation. Bleeding tendencies …

Severely Prolonged Vancomycin Half-life in a Patient with Normal Serum Creatinine and Creatinine Clearance

Jeffrey W. Jansen, Ryan P. Moenster

pp. 52–5 · DOI: 10.4103/jpp.JPP_101_17 · Published 2018

Vancomycin remains the antibiotic of choice to treat resistant Gram-positive infections and is dosed utilizing weight-based protocols or pharmacokinetic calculations. Pharmacokinetic calculations are a more proactive app…

The Indian Council of Medical Research (ICMR), the apex

Raj, Priyadarshini

pp. 56–57 · DOI: · Published 2018