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Article

Synthesis, Anti-inflammatory and Antioxidant Activity of Mannich Bases of Dehydrozingerone Derivatives

Hayun Hayun1★, Arif Arrahman1, Euis Maras Purwati1, Arry Yanuar1, Fransisca Fortunata1, Freddyhan Suhargo1, Discka Winda Syafiqah1, Carissa Ignacia1, Agnes Rebecca Novalia1★ Corresponding author

  1. 1Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.

CORRESPONDENCE

Hayun Hayun

Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.

hayun.ms06@gmail.com

Received: 29-11-2017; Revised: 28-01-2018; Accepted: 12-03-2018.

Volume 10, Issue 2S · pp. S6–S10 · PUBLISHED · DOI: 10.5530/jyp.2018.2s.2

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ABSTRACT

Objectives:This study aims to synthesize a series of five new Mannich bases of dehydrozingerone (DHZ) derivatives and to evaluate for their antiinflammatory and antioxidant activity. Materials and Methods:The synthesis was performed by refluxing DHZ with formaldehyde and secondary amines, and the structures of the synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C-NMR, and HR-MS. The anti-inflammatory and antioxidant activity evaluations were done by inhibition of heat-induced albumin denaturation and a free-radical DPPH method, respectively. Results:All the synthesized compounds (2a-e) showed anti-inflammatory and antioxidant activity. The highest anti-inflammatory activity was shown by compound 2c. The activity was comparable to the that of diclofenac sodium as a standard. While, the highest antioxidant activity was demostrated by compound 2e. The compound showed moderate activity compared to that of quercetin as a standard. Mostly of Mannich base derivatives of DHZ compounds exhibited higher antioxidant activity than that of DHZ.Conclusion:A series of five new Mannich bases of DHZ (2a-e) was synthesized successfully. Compound 2c demonstrated anti-inflammatory activity which was comparable to diclofenac sodium, while compound 2e exhibited moderate antioxidant activity compared to quercetin as standard.

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    Hayun, H., Arrahman, A., Purwati, E. M., Yanuar, A., Fortunata, F., Suhargo, F., Syafiqah, D. W., Ignacia, C., & Novalia, A. R. (). Synthesis, Anti-inflammatory and Antioxidant Activity of Mannich Bases of Dehydrozingerone Derivatives. Journal of Young Pharmacists, 10(2S), S6–S10. https://doi.org/10.5530/jyp.2018.2s.2