Volume 10, Issue 2S

Original Article

1. Article

   Problem-Based Learning in Reflective Pedagogy Paradigm: Innovative Learning in Pharmaceutical Care

   Hartayu T S, Wijoyo J, Donowati M W

   pp. S1–S5 · DOI: 10.5530/jyp.2018.2s.1 · Published

   Objectives:Problem based learning method is one of the learning process in practicing pharmaceutical care in Indonesia. On the other hand, the effective strategy in learning process and character building is reflective p…

2. Article

   Synthesis, Anti-inflammatory and Antioxidant Activity of Mannich Bases of Dehydrozingerone Derivatives

   Hayun Hayun, Arif Arrahman, Euis Maras Purwati, Arry Yanuar, Fransisca Fortunata, Freddyhan Suhargo, Discka Winda Syafiqah, Carissa Ignacia, Agnes Rebecca Novalia

   pp. S6–S10 · DOI: 10.5530/jyp.2018.2s.2 · Published

   Objectives:This study aims to synthesize a series of five new Mannich bases of dehydrozingerone (DHZ) derivatives and to evaluate for their antiinflammatory and antioxidant activity. Materials and Methods:The synthesis w…

3. Article

   Comparison of the Characteristics of Transfersomes and Protransfersomes Containing Azelaic Acid

   Iskandarsyah I, Aulia Dwi Rahmi, Dwita Medya Pangesti

   pp. S11–S15 · DOI: 10.5530/jyp.2018.2s.3 · Published

   Objectives: Recently developed agent carriers, transfersomes, which are sufficiently deformable to penetrate into or across the skin barrier. Protransfersome is the lyophilization of transfersome by removing the water sy…

4. Article

   In silico Activity Analysis of Saponins and 2, 5-Piperazinedione from Marine Organism against Murine Double Minute-2 Inhibitor and Procaspase-3 Activator

   Arry Yanuar, Indah Pratiwi, Rezi Riadhi Syahdi

   pp. S16–S19 · DOI: 10.5530/jyp.2018.2s.4 · Published

   Objectives:Cancer is a disease that can occur because of apoptosis failure. One of the causes of apoptosis failure is the presence of MDM2 inhibiting the activity of p53 so procaspase-3 could not be activated to caspase-…

5. Article

   Molecular Docking and Dynamic Simulation Studies of Benzoylated Emodin into HBV Core Protein

   Firdayani F, Ade Arsianti, Churiyah C, Arry Yanuar

   pp. S20–S24 · DOI: 10.5530/jyp.2018.2s.5 · Published

   Objectives: The hepatitis B virus (HBV) core protein was chosen as receptor target for a new, selective and effective due to resistance of current hepatitis B drugs against reverse transcriptase. It forms the capsid of v…

6. Article

   Molecular Dynamic Simulation Analysis on Marine Fungi Compounds Against EGFR and VEGFR-2 Inhibitory Activity in Non-Small Cell Lung Cancer

   Arry Yanuar, Kinanti Khansa Chavarina, Rezi Riadhi Syahdi

   pp. S25–S31 · DOI: 10.5530/jyp.2018.2s.6 · Published

   Introduction:According to International Agency for Research on Cancer (IARC), the number of lung cancer patients has reached 1.8 million lives, and 85% of the number contribute to non-small cell lung cancer. In the past …

7. Article

   Analysis of Compounds Isolated from Gnetum gnemon L. Seeds as Potential ACE Inhibitors through Molecular Docking and Molecular Dynamics Simulations

   Muhammad Aranza Triputra, Arry Yanuar

   pp. S31–S39 · DOI: 10.5530/jyp.2018.2s.7 · Published

   Objective:Gnetum gnemon L. (melinjo) seed extracts have been known to have some biological activities. One of them is ACE (angiotensinconverting enzyme) inhibitor. The present study was conducted to predict potential ACE…

8. Article

   Metabolite Profiling Analysis of Conventional and Non-Conventional Extraction Methods on Secondary Metabolite from Peperomia pellucida (L.) Kunth using UPLC-QToF-MS/MS System

   Islamudin Ahmad, Kamarza Mulia, Arry Yanuar, Abdul Mun’im

   pp. S40–S44 · DOI: 10.5530/jyp.2018.2s.8 · Published

   Objective: The purpose of this study was to observe the difference of extraction method (both conventional and non-conventional) based on metabolite profile using UPLC-QToF-MS/MS system from Peperomia pellucida (L.) Kunt…

9. Article

   Development of Glimepiride Solid Dispersion using the Coprocessed Excipients of Polyvinylpyrrolidone, Maltodextrin, and Polyethylene Glycol

   Silvia Surini, Claudia Nelrima Evangelista, Raditya Iswandana

   pp. S45–S50 · DOI: 10.5530/jyp.2018.2s.9 · Published

   Objectives: The aim of this work was to produce the solid dispersion of glimepiride (GMP-SD) based on the coprocessed excipient of polyvinylpyrrolidon (PVP), maltodextrin (MD) and polyethylene glycol (PEG). Methods:The P…

10. Article

    Cosmetic Serum Containing Grape (Vitis vinifera L.) Seed Extract Phytosome: Formulation and in vitro Penetration Study

    Silvia Surini, Helmy Mubarak, Delly Ramadon

    pp. S51–S55 · DOI: 10.5530/jyp.2018.2s.10 · Published

    Objective:Grape seed extract (GSE) contains abundant phenolic compounds with high antioxidant activity. Phenolic compounds in GSE have an inadequate penetration due to its hydrophilicity. The objective of this research w…

11. Article

    Formulation and Evaluation of Phytosome-Loaded Maltodextrin-Gum Arabic Microsphere System for Delivery of Camellia sinensis Extract

    Effionora Anwar, Nadira Farhana

    pp. S56–S62 · DOI: 10.5530/jyp.2018.2s.11 · Published

    Background:Phytosome is a nanovesicle that combines plant extracts and phospholipids to produce more soluble fat complex and provide better absorption. The Camellia sinensis (green tea leaf) extract has an abundant amoun…

12. Article

    Formulation of Transfersomal Green Tea (Camellia sinensis L. Kuntze) Leaves Extract Cream and in vitro Penetration Study Using Franz Diffussion Cell

    Delly Ramadon, Marsha Harme, Effionora Anwar

    pp. s63–s68 · DOI: 10.5530/jyp.2018.2s.12 · Published

    Introduction: Green tea is a natural ingredient that contains polyphenolic compounds in the form of catechin derivatives known as epigallocatechin gallate (EGCG). It has an antioxidant activity that is beneficial for bod…

13. Article

    Formulation, Stability Test and in vitro Penetration Test of Emulgel from Tobacco Leaves Extract

    Mahdi Jufri, Rachmadiva r, Misri Gozan, Eko Agus Suyono

    pp. s69–s72 · DOI: 10.5530/jyp.2018.2s.13 · Published

    Background: Tobacco is widely used as the main raw material of cigarette, however it also can be used as a mosquito repellent. Since tobacco contains nicotine, d-limone, indol, and pyridine, that can be used as an altern…

14. Article

    Formulation and Evaluation of Chloramphenicol Hydrogel Ophthalmic Preparation

    Insan Sunan Kurniawansyah, Iyan Sopyan, Yoga Windu Wardhana, Mohanapriya Gunasekaran

    pp. s73–s78 · DOI: 10.5530/jyp.2018.2s.14 · Published

    Objective: To generate a hydrogel to increase the retention time of a drug in an ophthalmic drug delivery system. Methods: Research was conducted on the formulation and evaluation of a safe-to-use chloramphenicol ophthal…

15. Article

    Preparation and Characterization of Microcrystalline Cellulose Produced from Betung Bamboo (Dendrocalamus asper) through Acid Hydrolysis

    Rd Roro Altrista Yusrina Kharismi, Sutriyo, Herman Suryadi

    pp. s79–s83 · DOI: 10.5530/jyp.2018.2s.15 · Published

    Introduction: Microcrystalline cellulose (MCC) is an excipient used in food, cosmetics and pharmaceutical industries especially in the manufacture of tablet. Dendrocalamus asper (betung bamboo) contains high cellulose co…

16. Article

    The Preparation and Characterization of Ethanol Extract Nanoparticle from Rhaphidophora pinnata (L.f.) Schott Leaves by using Arabic Gum and Dextrin

    Sumaiyah S, Masfria M, Izmi Yolanda Rusdi, Aminah Dalimunthe

    pp. s84–s86 · DOI: 10.5530/jyp.2018.2s.16 · Published

    Objective: This research was aimed to prepare and characterize the ethanol extract nanoparticles of Rhaphidophora pinnata leaves by using arabic gum and dextrin. Method: The Rhaphidophora pinnata leaves extract was obtai…

17. Article

    Characterization of Microcrystalline Cellulose Obtained from Enzymatic Hydrolysis of Alpha-Cellulose and its Application

    Herman Suryadi, Sutriyo s, Monica Angeline, Mitayani Wahyu Murti

    pp. s87–s92 · DOI: 10.5530/jyp.2018.2s.17 · Published

    Objective: This study was aimed to prepare microcrystalline cellulose (MCC) powder from α-cellulose of water hyacinth, find its characteristics and purity compared to Avicel PH 101 as reference and its tablets evaluation…

18. Article

    Antioxidant Activity of Rubus fraxinifolius Poir. and Rubus rosifolius J. Sm. Leaves

    Yesi Desmiaty, Berna Elya, Fadlina Chany Saputri, Muhammad Hanafi, Rini Prastiwi

    pp. s93–s96 · DOI: 10.5530/jyp.2018.2s.18 · Published

    Objective: Rubus fraxinifolius and R. rosifolius are found growing in mountainous areas of West Java and potentially act as an antioxidant. The objective of this research was to examine the antioxidant activity of Rubus …

19. Article

    Antimicrobial Activity of Ethyl Acetate Fraction from Stelechocarpus burahol Fruit against Oral Bacteria and Total Flavonoids Content

    Asni Amin, Maksum Radji, Abdul Mun’im, Anton Rahardjo, Herman Suryadi

    pp. s97–s100 · DOI: 10.5530/jyp.2018.2s.19 · Published

    Objective: Stelechocarpus burahol is one of the native plants of Indonesia that has been used as an oral deodorant. This fruit contains flavonoids, which flavonoids are known to have antimicrobial activity against oral b…

20. Article

    In vitro Permeation Study of Ketoprofen Patch with Combination of Ethylcellulose and Polyvynil Pyrrolidone as Matrix Polymers

    K. Pavithra, K. Pavithra

    pp. s101–s105 · DOI: 10.5530/jyp.2018.2s.20 · Published

    Objective: Transdermal patch can release drug to provide systemic pharmacological effect. Matrix used in the patch formula influences the release of the drug. The aim of the study was to evaluate permeation of Ketoprofen…

21. Article

    In-vitro and in-vivo Sunscreen Activity of Active Compounds Isolated from Fruits of Phaleria marcocarpha (Scheff.) Boerl

    Aprilita Rina Yanti Eff, Ratih Dyah Pertiwi, Irvani Rakhmawati, Tyas Putri Utami

    pp. s106–s110 · DOI: 10.5530/jyp.2018.2s.21 · Published

    Objective: Mahkota dewa fruits (Phaleria marcocarpha (Scheff.) Boerl) have been found to contain benzophenone and xanthone derivatives which have a protective effect against ultraviolet light. This study was aimed to eva…

22. Article

    Arginase Inhibition Activity of Stem Bark Extract of Caesalpinia pulcherrima

    Lutfi Tsara Zalsabela, Berna Elya, Arikadia Noviani

    pp. s111–s113 · DOI: 10.5530/jyp.2018.2s.22 · Published

    Background: Inhibition of arginase activity can ameliorate endothelial dysfunction in vascular system which can cause some cardiovascular diseases. This study was aimed to test the arginase activity inhibition of n-hexan…

23. Article

    Inhibitory Effect on Arginase and Total Phenolic Content Determination of Extracts from Different parts of Melastoma malabathricum L.

    Elin Novia Sembiring, Berna Elya, Rani Sauriasari

    pp. s114–s117 · DOI: 10.5530/jyp.2018.2s.23 · Published

    Background: Some phenolic compounds are potential source for arginase inhibitor that can be used in management of disease associated with endothelial dysfunction. Objective: The aim of this study was to investigate the i…

24. Article

    Repellent Activity of Essential Oils from Cananga odorata Lamk. and Cymbopogon nardus L. on Corn Starch-Based Thixogel

    Nasrul Wathoni, Sriwidodo s, Ferry Ferdiansyah Sofian, Angga Cipta Narsa, Ajeng Ninda Mutiara

    pp. s118–s123 · DOI: 10.5530/jyp.2018.2s.24 · Published

    Objective: The main objective of the research work was to fabricate and characterize the thixogel formulations based on corn starch containing the combination of the essential oils from ylang-ylang (Cananga odorata Lamk.…

25. Article

    Effects of Bungur Leaves (Lagerstroemia speciose (L.) Pres.) on Malondialdehyde and Blood Glucose Levels in Hyperglycemic Mice

    Rika Sari Dewi, Lestari Rahayu, Ni Made Dwi Sandhiutami, Oci Purnama Sari

    pp. s124–s127 · DOI: 10.5530/jyp.2018.2s.25 · Published

    Background: Bungur leaves have saponins, tannins, ellagitannin and flavonoids that could function as antioxidant and antihyperglycemic. Bungur leaves also consumed in Indonesia people for their diabetes treatment for a l…

26. Article

    Cost-effectiveness Analysis of Deferiprone and Deferasirox on Thalassemia Major Patients in Tangerang District Hospital, Indonesia

    Hana Ghina Chairunnisa, Rani Sauriasari, Nanda Asyura Rizkyani

    pp. s128–s131 · DOI: 10.5530/jyp.2018.2s.26 · Published

    Background: Blood transfusion are needed in improving the quality of life of thalassemia major patients. However since it can lead to excess iron, the iron chelation therapy is needed. Deferiprone and deferasirox are the…

27. Article

    Effectiveness of Sweet Orange Peel Extract (Citrus sinensis) on the Improvement of Liver Functions of Animal Trials Induced by Cigarette Smoke

    Ika Setyawati, Riska Anggraeni

    pp. s132–s135 · DOI: 10.5530/jyp.2018.2s.27 · Published

    Objective: Cigarette smoke contains harmful substances such as molecular compounds, reactive oxygen and nicotine compounds that can increase levels of Serum Glutamate-Pyruvate Transaminase (SGPT) and Serum Glutamic Oxalo…

28. Article

    Wound Healing Activity of Aucubin on Hyperglycemic Rat

    Kartini k, Ridho Islamie, Claudia Stefanie Handojo

    pp. s136–s139 · DOI: 10.5530/jyp.2018.2s.28 · Published

    Objective: Impaired wound healing in diabetic patients is a serious complication leading to amputation and even death. Proper diabetic wound management is needed to improve the quality of life of diabetic patients. Plant…

29. Article

    Pilot Study of Isoniazid Acetylation in Melanesian Healthy Subject from Indonesia

    Novi Yantih, Yahdiana Harahap, Rianto Setiabudy, Wahono Sumaryono

    pp. s140–s144 · DOI: 10.5530/jyp.2018.2s.29 · Published

    Objective: Isoniazid (INH) is metabolized by N-acetyl transferase-2 into acetyl isoniazid (Ac-INH). The acetylation rate is different in each ethnic, therefore it is very interesting to study of INH acetylation. The aims…

30. Article

    Use of Complementary and Alternative Medicine (CAM) among Breast Cancer Patients in a Public Hospital in Padang, Indonesia

    Dedy Almasdy, Elsa Eptiyeni, Daan Khamri, Nina Kurniasih

    pp. s145–s147 · DOI: 10.5530/jyp.2018.2s.30 · Published

    Objective: Number of CAM user among person suffer from cancer was high, especially breast cancer. The aim of this study was to investigate the use of CAM in breast cancer patients in a public hospital in Padang, Indonesi…

31. Article

    Computational Studies and Molecular Dynamic Simulation to Design Lead Compounds for Hepatitis B Virus

    Alfan Danny Arbianto, Firdayani f, Susi Kusumaningrum, Raodatul Jannah, Puspa Dewi N Lotulung, Muhammad Hanafi

    pp. s148–s152 · DOI: 10.5530/jyp.2018.2s.31 · Published

    Objective/Background: A novel approach to develop anti-Hepatitis B Virus (HBV) by computational studies is proposed. Methodology: It used active compounds as the standard ligand. There are six parameters such as docking …