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In-vitro and in-vivo Sunscreen Activity of Active Compounds Isolated from Fruits of Phaleria marcocarpha (Scheff.) Boerl

Aprilita Rina Yanti Eff1★, Ratih Dyah Pertiwi1, Irvani Rakhmawati1, Tyas Putri Utami1★ Corresponding author

  1. 1Department of Pharmacy, Faculty of Health Sciences, Universitas Esa Unggul, INDONESIA.

CORRESPONDENCE

Aprilita Rina Yanti Eff

Department of Pharmacy, Faculty of Health Sciences, Universitas Esa Unggul, INDONESIA.

aprilita.rinayanti@esaunggul.ac.id

Received: 11-01-2018; Revised: 28-01-2018; Accepted: 12-03-2018.

Volume 10, Issue 2S · pp. s106–s110 · PUBLISHED · DOI: 10.5530/jyp.2018.2s.21

View on JYP original site ↗

ABSTRACT

Objective: Mahkota dewa fruits (Phaleria marcocarpha (Scheff.) Boerl) have been found to contain benzophenone and xanthone derivatives which have a protective effect against ultraviolet light. This study was aimed to evaluate the sunscreen activities of mahkoside A, mangiferin and 6, 4-dihydroxy- 4-methoxybenzophenone-2-O-β-D-glucopyranoside (6, 4-DHMP) isolated from Mahkota dewa fruits in-vitro and in-vivo. Methods:In-vitro sunscreen activity was evaluated using spectrophotometric method by measuring percentage transmission of erythema, percentage transmission of pigmentation and sun protection factor (SPF). The sunscreen activity assays in-vivo was conducted by observing the effect of erythema in rats after exposed to an exotera lamp for 24 h. Results: In-vitro assays showed that mahkoside A, mangiferin and 6, 4-dihydroxy-4-methoxybenzophenone-2-O-β-Dglucopyranoside at a concentration of 100 ppm had SPF value of 3.44, 2.82 and 3.08 respectively. In-vivo test results showed that mangiferin at concentrations of 12.5%, 25%, and 50% decreased the amount of erythema and erythema diameter significantly different than negative control (p Conclusion: Mahkoside A, mangiferin and 6, 4-DHMP possessed sunscreen activity in-vitro and in-vivo.

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    Eff, A. R. Y., Pertiwi, R. D., Rakhmawati, I., & Utami, T. P. (). In-vitro and in-vivo Sunscreen Activity of Active Compounds Isolated from Fruits of Phaleria marcocarpha (Scheff.) Boerl. Journal of Young Pharmacists, 10(2S), s106–s110. https://doi.org/10.5530/jyp.2018.2s.21