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Article

Antioxidant Activity of Rubus fraxinifolius Poir. and Rubus rosifolius J. Sm. Leaves

Yesi Desmiaty1,2, Berna Elya1★, Fadlina Chany Saputri1, Muhammad Hanafi2,3, Rini Prastiwi4★ Corresponding author

  1. 1Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.
  2. 2Faculty of Pharmacy, Pancasila University, Jakarta, INDONESIA.
  3. 3Research Centre for Chemistry Indonesian Institute of Sciences, Jakarta, INDONESIA.
  4. 4Faculty of Pharmacy, Muhammadiyah Prof. Dr. Hamka University, Jakarta, INDONESIA.

CORRESPONDENCE

Berna Elya

Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.

berna.elya@ui.ac.id

Received: 19-11-2017; Revised: 28-01-2018; Accepted: 12-04-2018.

Volume 10, Issue 2S · pp. s93–s96 · PUBLISHED · DOI: 10.5530/jyp.2018.2s.18

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ABSTRACT

Objective: Rubus fraxinifolius and R. rosifolius are found growing in mountainous areas of West Java and potentially act as an antioxidant. The objective of this research was to examine the antioxidant activity of Rubus rosifolius J. Sm. and R. fraxinifolius Poir. leaves. Methods: Dried leaves powder were extracted using Soxhlet apparatus with n-hexane, ethyl acetate, and methanol. The extracts were evaporated, and antioxidant activity was determined using DPPH free radical scavenger methods as well as FRAP reduction capability. Total phenolic contents from the extract gave the best antioxidant activity was measured by the Folin-Ciocalteu method. Results: IC50 of DPPH scavenging activity of n-hexane, ethyl acetate and methanolic extracts ofR. fraxinifolius were >200; 140.97; and 4.48 ppm, while for R. rosifolius were >200; 29.67; and 5.17 ppm, respectively. Percent FRAP capacity of R. fraxinifolius in 25 ppm were 55.65; 89.47; and 97.65 %, while forR. rosifolius were 73.51; 82.83; and 96.5, respectively. Total phenolic content of the methanolic extract of R. fraxinifolius and R. rosifolius were 39.0 + 26.5 and 80.62+21.6 mg GAE/g extract. Conclusion: Both methanolic extracts showed a significant optimum trapping capability of free radicals and the hexane extracts did not show antioxidant activity. Thus, it may be concluded that the methanolic extracts of both leaves possess potent antioxidant properties and had high total phenolic content. This investigation provides promising results to emphasize the importance of antioxidant capabilities of both plants.

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    Desmiaty, Y., Elya, B., Saputri, F. C., Hanafi, M., & Prastiwi, R. (). Antioxidant Activity of Rubus fraxinifolius Poir. and Rubus rosifolius J. Sm. Leaves. Journal of Young Pharmacists, 10(2S), s93–s96. https://doi.org/10.5530/jyp.2018.2s.18