Wilson Disease with Hepatic Impairment and Thrombocytopenia: A Case Report
Krishnan Karthickeyan1★, Chegireddy Mahindranath Reddy1, Jahangeer Batcha Noor Mohamed1, Kothagundu Vaibhavi1★ Corresponding author
- 1Department of Pharmacy Practice, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Kanchipuram, Tamil Nadu, INDIA.
CORRESPONDENCE
Krishnan Karthickeyan
Department of Pharmacy Practice, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Kanchipuram, Tamil Nadu, INDIA.
Received: 25-01-2018; Revised: 08-05-2018; Accepted: 22-06-2018.
Volume 10, Issue 3 · pp. 371–373 · PUBLISHED · DOI: 10.5530/jyp.2018.10.82
ABSTRACT
Introduction: Wilson disease is a rare autosomal recessive disorder. The Case report describes the penicillamine induced thrombocytopenia. Case Report:A 14-year-old girl presented with previously diagnosed with Wilson disease treated with penicillamine and pyridoxine. Complaints of dyskinesia, slurred speech, severe hyperbilirubinemia and prominent extrapyramidal features consisting of the rigidity, tremors and ophthalmic examination of her eyes reveal the Kayser-Fleischer ring and sunflower cataract and low blood count. Conclusion:Wilson disease is a rare inherited disorder. Approximately 30% of the patient cannot tolerate penicillamine due to early hypersensitivity or bone marrow suppression or renal failure occurs due to the failure of therapy. Hence zinc is considered an alternative therapy for pediatric patients.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Karthickeyan, K., Reddy, C. M., Mohamed, J. B. N., & Vaibhavi, K. (). Wilson Disease with Hepatic Impairment and Thrombocytopenia: A Case Report. Journal of Young Pharmacists, 10(3), 371–373. https://doi.org/10.5530/jyp.2018.10.82