jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Journal of Young PharmacistsNOW IN
Article

Development and Validation of Microbiological Analytical Method for Determination of Potency of Voriconazole Tablets

Mami Sahitya1, Sana Fathima1★, Ancha Divya1, Kyadari Vaishali1, Meshkhana NidhiSree1, Challoori Spandana Reddy1, Toleti Sree Ramya1, Sandhya Rani1, Yenumula Padmavathi1, Ravi Kiran2★ Corresponding author

  1. 1Department of Pharmaceutical Analysis, G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana, INDIA.
  2. 2Department of Biotechnology, G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana, INDIA.

CORRESPONDENCE

Sana Fathima

Department of Pharmaceutical Analysis, G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana, INDIA.

fatimasana051@gmail.com

Received: 12-03-2020; Revised: 13-05-2020; Accepted: 02-07-2020.

Volume 12, Issue 2S · pp. s113–s116 · PUBLISHED · DOI: 10.5530/jyp.2020.12s.58

View on JYP original site ↗

ABSTRACT

A new microbiological method was developed for analysis of voriconazole tablets using Candida albicans as test microorganism. Various media, species and conditions were used to optimize the diffusion test. A prospective validation of the system showed adequate linearity (0.995), accuracy (RSD<2%) and consistency (mean recovery= 101.77%). High performance liquid chromatography was selected as a tool of comparison for evaluating voriconazole. Results of both the microbiological and HPLC methods have been compared with the student t-test and the voriconazole content determined by both methods has shown strong correlation. The developed microbiological analytical method provides true indication of biological activity and can be used in dosage forms for routine quality control analysis of voriconazole.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Sahitya, M., Fathima, S., Divya, A., Vaishali, K., NidhiSree, M., Reddy, C. S., Ramya, T. S., Rani, S., Padmavathi, Y., & Kiran, R. (). Development and Validation of Microbiological Analytical Method for Determination of Potency of Voriconazole Tablets. Journal of Young Pharmacists, 12(2S), s113–s116. https://doi.org/10.5530/jyp.2020.12s.58