Comparative Physicochemical Analysis of Kushta-E-Murdarsang Prepared by Classical and Muffle Furness Method
Mohd Akhtar Ali1, Hamiduddin H2★, Mohammad Zaigham2, Sana Nafees2, Mohammad Ikram2, Gazi Jahangeer2★ Corresponding author
- 1Department of Ilmul Saidla (Unani Pharmacy), Z.H. Unani Medical Collage and Hospital, Siwan, Bihar, INDIA.
- 2Department of Ilmul Saidla (Unani Pharmacy), National Institute of Unani Medicine (NIUM), Kottigepalya, Magadi Main road, Bengaluru, Karnataka, INDIA.
CORRESPONDENCE
Hamiduddin H
Department of Ilmul Saidla (Unani Pharmacy), National Institute of Unani Medicine (NIUM), Kottigepalya, Magadi Main road, Bengaluru, Karnataka, INDIA.
Received: 06-06-2021; Revised: 02-07-2021; Accepted: 29-07-2021.
Volume 13, Issue 3 · pp. 205–210 · PUBLISHED · DOI: 10.5530/jyp.2021.13.43
ABSTRACT
Aim:Kushta-e-Murdarsang a herbo-mineral calx preparation was prepared as per classical and contemporary method and its physico-chemical and elemental analysis for standardization and safety evaluation (by heavy metal estimation) was performed. Methods:Murdarsang (Litharge mineral) was subjected to Mudabbar / Shodhan (processing) by Sheere-Madar (Latex of Calotropis gigantea Linn. R. Br. ex. Ait.) and calcined by classical and muffle furness method. Comparative Physico-chemical investigation for safety evaluation and standardization were done by X-ray diffraction (XRD), inductively coupled plasma mass spectrometry (ICP-MS), Atomic absorption spectroscopy (AAS) and other analytical parameters. Results:Both the sample Kushta-e-Murdarsang classical method (KM-CM) and Kushta-e-Murdarsang Muffle Furnace method (KM-MFM) passed specification tests as per Unani Medicine. Both the sample KM-CM and KM-MFM showed presence of heavy metals. In XRD analysis both the samples showed presence of Lead, sample KM-MFM revealed presence of Litharge syn- PbO phase, where KM-CM revealed presence of Lead syn- Pb, Galena syn- Pb S and Litharge syn- PbO phase. In ICP-MS analysis the Cadmium (Cd) content was 0.65 ppm and 0.65 ppm; Mercury (Hg) 54.17 ppm and 68.08 ppm and Arsenic (As) was 21.27 ppm and 0.11 ppm accordingly, in AAS analysis the Lead (Pb) content was 55.0 % and 51.4% in KM-MFM and KM-CM respectively. Conclusion: KM-MFM can be a better choice in respect of only ease of preparation, both the sample prepared by classical along with muffle furnace method contains heavy metal above permissible limit and KM-CM contain reduced quantity of heavy metal in respect of MF method. XRD and other standardization data for the formulation were set in.
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Ali, M. A., H, H., Zaigham, M., Nafees, S., Ikram, M., & Jahangeer, G. (). Comparative Physicochemical Analysis of Kushta-E-Murdarsang Prepared by Classical and Muffle Furness Method. Journal of Young Pharmacists, 13(3), 205–210. https://doi.org/10.5530/jyp.2021.13.43