jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Journal of Young PharmacistsNOW IN
Article

Assessment of Hepatoprotective and Antioxidant Activities of Ethanolic Extract of Tephrosia villosa in Albino Rats

Chakali Ayyanna1★, Boyini Mounika1, Sree Sudha Tanguturi Yella2, Pugazhenthan Thangaraju2★ Corresponding author

  1. 1Department of Pharmacology, CES College of Pharmacy, Kurnool, Andhra Pradesh, INDIA.
  2. 2Department of Pharmacology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, INDIA.

CORRESPONDENCE

Chakali Ayyanna

Department of Pharmacology, CES College of Pharmacy, Kurnool, Andhra Pradesh, INDIA.

sudhanmcmbbs@gmail.com

Received: 06-06-2021; Revised: 19-07-2021; Accepted: 02-09-2021.

Volume 13, Issue 3 · pp. 229–234 · PUBLISHED · DOI: 10.5530/jyp.2021.13.47

View on JYP original site ↗

ABSTRACT

Objectives: To Study the hepatoprotective and antioxidant activity of the whole plant, ethanolic extract of Tephrosia villosa (EETV). Methods:Hepatoprotective effect of EETV is studied against carbon tetrachloride (CCl4 ) and paracetamol-induced hepatotoxicity in rats. Individual rats received EETV doses of 200 and 400 mg/kg (w/w) for seven days, respectively. On the 7th day, induced hepatotoxicity in all rats of all groups by 1.25 ml/kg (i.p) CCl4 and paracetamol 1gm/kg/p.o. Determining effects of ETEV on antioxidant activity, SGOT, SGPT, ALP, and direct bilirubin were, and also performed a histopathological exam of the liver sections. Results:The extract prevented the exhaustion of glutathione and catalase levels and increased lipid peroxidation levels against CCl4 induced and Paracetamol liver injury in rats. By histopathological evidence, EETV also significantly decreased biochemical levels of liver enzymes with high hepatoprotection at 200 mg/kg.Conclusion:Present study results strongly reveal that EETV has hepatoprotective and antioxidant activity against CCl4 and paracetamolinduced hepatic impairment in experimental animals.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Ayyanna, C., Mounika, B., Yella, S. S. T., & Thangaraju, P. (). Assessment of Hepatoprotective and Antioxidant Activities of Ethanolic Extract of Tephrosia villosa in Albino Rats. Journal of Young Pharmacists, 13(3), 229–234. https://doi.org/10.5530/jyp.2021.13.47