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Article

Evaluation of Hypolipidemic activity of Fragaria vesca Polyphenols in High-Fat Diet-Induced Hyperlipidemia in Wistar Rats

Venkataramana Yella1, S. Rajeshkumar2★, K. Jagadeesh3, Hemasankar C4★ Corresponding author

  1. 1Department of Pharmacology, Saveetha Medical College, Chennai, Tamil Nadu, INDIA.
  2. 2Department of Pharmacology, Saveetha Dental College, Chennai, Tamil Nadu, INDIA.
  3. 3Department of Pharmacology, Basaveshwara Medical College, Chitradurga, Karnataka, INDIA.
  4. 4Department of Physiology, Saveetha Medical College, Chennai, Tamil Nadu, INDIA.

CORRESPONDENCE

S. Rajeshkumar

Department of Pharmacology, Saveetha Dental College, Chennai, Tamil Nadu, INDIA.

ramana11223@gmail.com

Received: 15-01-2023; Revised: 19-02-2023; Accepted: 02-03-2023.

Volume 15, Issue 2 · pp. 278–282 · PUBLISHED · DOI: 10.5530/jyp.2023.15.37

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ABSTRACT

Background: Dyslipidemia is a major public health issue in developed and developing countries, and it is a major risk factor for ischemic heart disease, atherosclerosis, and cerebrovascular accidents. The current trend is most of the antihyperlipidemic drugs like atorvastatin, fibrates, statins, nicotinic acid, probucol, and other chemical formulations were extensively used to treat hyperlipidemia clinically. The because of their serious adverse effects including diarrhea, nausea, myositis, and altered liver functions with statins and their use is restricted. Fragaria vesca is commonly consumed by the population in a routine lifestyle.and it has lipid-lowering properties Hence, the present study is planned to investigate the hypolipidemic activity of Fragaria vesca fruit extract on high-fat diet-induced hyperlipidemia in Wistar albino rats was studied.Material and Methods: In all groups except Group - I, a high-fat diet was given orally. The study included sixty-six male Wistar albino rats weighing 180-200 gm. After one week of growth, the animals were divided into eleven groups, each group contain six Wistar albino rats, and they were randomly assigned. Fragaria vesca fruit extractwas given orally and estimated body weight, lipid profile, and blood sugar levels were in all the groups before and after the induced fat model in Wistar albino rats. Results:According to the findings, ellagicacid (500mg/kg per oral for 4 weeks), Fragaria vesca (500mg/kg per oral for 4 weeks), tocopherol (500mg/kg per oral for 4 weeks), zinc oxide FV (250mg/kg per oral for 4 weeks), zinc oxide FV (500mg/kg per oral for 4 weeks) were effective into decreases Total Cholesterol, Triglycerides, and LDL and Increasing HDL in the management of hyperlipidemia. Conclusion:The study concluded that the Phytochemical compound of Fragaria vesca showed a significant decrease in the levels of lipid profile Total Cholesterol, Triglycerides, LDL, and Increased HDL in high fat-induced hyperlipidemic Wistar albino rats.

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    Yella, V., Rajeshkumar, S., Jagadeesh, K., & C, H. (). Evaluation of Hypolipidemic activity of Fragaria vesca Polyphenols in High-Fat Diet-Induced Hyperlipidemia in Wistar Rats. Journal of Young Pharmacists, 15(2), 278–282. https://doi.org/10.5530/jyp.2023.15.37