In vitro and in vivo Antidiabetic Evaluation of Synthesised Novel New Chromane and its Derivatives
Sonia Kamboj1,2, Jasmine Chaudhary1★, Akash Jain1, Randhir Singh3★ Corresponding author
- 1Department of Pharmaceutical Sciences, MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana, INDIA.
- 2Department of Pharmaceutical Sciences, Ch. Devi Lal College of Pharmacy, Jagadhri, Haryana, INDIA.
- 3Department of Pharmacology, Central University of Punjab, Bathinda, Punjab, INDIA.
CORRESPONDENCE
Jasmine Chaudhary
Department of Pharmaceutical Sciences, MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana, INDIA.
Received: 02-01-2023; Revised: 26-01-2023; Accepted: 11-02-2022.
Volume 15, Issue 2 · pp. 292–297 · PUBLISHED · DOI: 10.5530/jyp.2023.15.39
ABSTRACT
Background:To evaluate biological activity of synthesised new chromane and its analogues. Materials and Methods:New chromane {3,5,7-trihydroxy 2-(4-hydroxy benzyl) chroman-4-one} isolated from dried leaves of Dillenia indica Linn., family Dilleniaceae is structurally relating with various reported chroman-4-one derivatives displaying remarkable in vivo antidiabetic activity. But the literature reveals that 0.8 – 1.0% yield of pure new chromane was obtained in isolation. Following reported literature data of synthesis and in silico study; Synthesized new chromane and its derivatives (S23-S32) were investigated for in vitro (α-amylase and α-glucosidase) as well as in vivo antidiabetic evaluation respectively. Result and Conclusion:in vitro hypoglycaemic study also displayed the significant antidiabetic potential of new chromane and its O-alkyl substituents (especially S23) while other synthesized compounds (S27-S32) reported for moderate to mild effects w.r.t. reference drug (acarbose). Moreover, synthetic new chromane and O-alkyl substituent (S23) exhibited maximum antidiabetic activity also in terms of lowering glucose concentration while others (S27-S32) showed mild anti-diabetic effect in comparison to reference drug (metformin).
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Kamboj, S., Chaudhary, J., Jain, A., & Singh, R. (). In vitro and in vivo Antidiabetic Evaluation of Synthesised Novel New Chromane and its Derivatives. Journal of Young Pharmacists, 15(2), 292–297. https://doi.org/10.5530/jyp.2023.15.39