Synthetic Identification of New Compounds with Anti-fungal Properties of “1-[3-(2-Hydroxyphenyl)-3-Oxop ropanoyl]- 5,5-Diphenylimidazolidine -2,4-Dione and its Derivatives”
Rohit Jaysing Bhor1★, Shabnam Babu Shaikh1, Shirole Rahul Bapusaheb1, Satpute Pankaj Bhausaheb1, Mahesh Hari Kolhe2★ Corresponding author
- 1Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy Pravaranagar, Rahata, Ahmednagar, Maharashtra, INDIA.
- 2Department of Pharmaceutics, Pravara Rural College of Pharmacy Pravaranagar, Rahata, Ahmednagar, Maharashtra, INDIA.
CORRESPONDENCE
Rohit Jaysing Bhor
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy Pravaranagar, Rahata, Ahmednagar, Maharashtra, INDIA.
Received: 07-08-2023; Revised: 20-08-2023; Accepted: 02-09-2023.
Volume 15, Issue 4 · pp. 638–648 · PUBLISHED · DOI: 10.5530/jyp.2023.15.89
ABSTRACT
Background:5, 5-diphenylimidazolidine is a heterocyclic hydrocarbon having unique basic structural characteristics in their molecular structure. In this research; we synthesis various 11 derivatives of -[3-(2-hydroxyphenyl)-3-oxopropanoyl]- 5,5-diphenylimidazolidine -2,4-dione with anti-fungal activity. The agar well diffusion method was used to conduct the pharmacological screening for antifungal activity. Materials and Methods: All 5, 5-diphenylimidazolidine derivatives were synthesized by conventional method. Benzoin; Benzil; Urea; Glacial Acetic Acid; 4- hydroxyl benzoic acid; Con. HNO3 ; Formic Acid; 2- Nitro Aniline are used for the synthesis. The structure confirmations were done by FTIR, NMR spectroscopy and MS. Results:In this research; we concluded that; many derivatives give potent anti-fungal activity against fungi. The compound 1-[3-(oxo (phenyl amino)acetic acid)-3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione (BJ); 1-[3-(N-phenylformamide)-3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione (BG); 1-[3-(NPhenyl-2-nitroaniline)-3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione (BE); shown better antifungal activity against Candida albicans. BJ was shown to be the most effective chemical when compared to Griseofulvin and other common medications because it demonstrated greater antifungal action against Aspergillus niger. Conclusion: The anti-fungal activity of the title compounds and their derivatives was studied. Studies on the link between structure and activity revealed that compounds containing 5, 5-dimethylimidazolidinone derivatives with an electron-withdrawing group have higher activity than those containing an electron-donating group. 1-[3-(N-Phenyl-2-nitroaniline)-3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione (BE); 1-[3-(oxo(phenyl-amino) acetic acid)-3-oxopropanoyl]-5,5-diphenylimidazolidine-2,4-dione (BK) shown better antifungal activity against Candida albicans.
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Bhor, R. J., Shaikh, S. B., Bapusaheb, S. R., Bhausaheb, S. P., & Kolhe, M. H. (). Synthetic Identification of New Compounds with Anti-fungal Properties of “1-[3-(2-Hydroxyphenyl)-3-Oxop ropanoyl]- 5,5-Diphenylimidazolidine -2,4-Dione and its Derivatives”. Journal of Young Pharmacists, 15(4), 638–648. https://doi.org/10.5530/jyp.2023.15.89