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Synthesis and Biological Properties of 4-Chloro- N1-(5-Chloro-1H-Indol-1-yl)-N2-(2-Chlorophenyl) benzene-1,2-Diamine Derivatives

Nikita Shridhar Andhale1, Rohit Jaysing Bhor1★, Mahesh Hari Kolhe2, Tanishka Anil Pawar1, Pornima Ramdas Tambe1, Rupali Mahadev Ghule1, Sarthak Anil Bhange1, Bhakti Sharad Thete1, Pruthviraj Vijay Kute1, Pratik Vijay Malvade1, Jyoti Ramkisan Bhagat1, Poonam Prakash Waykar1★ Corresponding author

  1. 1Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy Pravaranagar, Rahata, Ahmednagar, Maharashtra, INDIA.
  2. 2Department of QA, Pravara Rural College of Pharmacy Pravaranagar, Rahata, Ahmednagar, Maharashtra, INDIA.

CORRESPONDENCE

Rohit Jaysing Bhor

Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy Pravaranagar, Rahata, Ahmednagar, Maharashtra, INDIA.

rohit.bhor69@gmail.com

Received: 10-04-2024; Revised: 20-04-2024; Accepted: 11-06-2024.

Volume 16, Issue 3 · pp. 498–505 · PUBLISHED · DOI: 10.5530/jyp.2024.16.64

View on JYP original site ↗

ABSTRACT

Background:Five-membered heterocycle with one neighbouring nitrogen atoms is present in the indole nucleus. Heterocyclic substances feature two adjacent benzene and pyrrole ring atoms. Indole are heterocyclic compounds with one oxygen ring that have a benzoannelated - pyrrole ring. Indole derivatives are highly valuable chemical synthesis and medicinal intermediates. Recent years have seen a surge in interest in the effective synthesis of indole blocks and associated functionalization’s, particularly the alkylation of indoles. The two following factors will be the main emphasis of this review: i) Recent advancements in the alkylation of indoles, namely those involving the N1-, C2- and C3-positions and the synthesis of indoles, which was facilitated by transition metals. Materials and Methods:Benzoic acid and ethanoic acid, propionic acid, hydroxylamine, 2,5 Dichloro aniline are used for the synthesis of indole derivatives were used for the synthesis of indole. Results:Compared to indomethacin, the anti-inflammatory results for the substances or their derivatives like N2-(biphenyl-2-yl)-4-chloro-N1-(5-chloro-1H-indol-1-yl)-4-am inobenzene-1,2-diamine NA5 (Scheme 1B); N2-(biphenyl-2-yl)-4-chloro-N1-(5-chloro-1H-ind ol-1-yl)-3-aminobenzene-1,2-diamine NA6 (Scheme 1B) and N2-(biphenyl-2-yl)-4-chloro-N1- (5-chloro-1H-indol-1-yl)-2-aminobenzene-1,2-diamine NA7 (Scheme 1B). Conclusion:Examined were the anti-inflammatory properties of the substances in the title and their derivatives. The compounds containing indole derivatives with an electron-withdrawing group have a higher activity than those containing an electron-donating group, according to research on the link between structure and activity. Summarising the data from the previously reviewed literature, we can say that indole has a broad spectrum of biological activity. Numerous opportunities exist to investigate indole for new therapeutic uses. Researchers worldwide will benefit from this study's coverage of the chemistry of indole derivatives in the design and synthesis of new pharmaceuticals that might be utilised to treat a range of diseases.

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    Andhale, N. S., Bhor, R. J., Kolhe, M. H., Pawar, T. A., Tambe, P. R., Ghule, R. M., Bhange, S. A., Thete, B. S., Kute, P. V., Malvade, P. V., Bhagat, J. R., & Waykar, P. P. (). Synthesis and Biological Properties of 4-Chloro- N1-(5-Chloro-1H-Indol-1-yl)-N2-(2-Chlorophenyl) benzene-1,2-Diamine Derivatives. Journal of Young Pharmacists, 16(3), 498–505. https://doi.org/10.5530/jyp.2024.16.64