Volume 16, Issue 3

· pp. 374–606 · 29 articles

Volume: 16
Issue: 3
Published
Pages: 374–606
Articles: 29
Sections: 3
ISSN: Print - 0975-1483 | Online - 0975-1505
Journal: JYP

Review Article Original Artcile Case Report

In this issue

Review Article

Review
A Concise Review of Qualitative Research Methods in Healthcare Research
Mohammad Daud Ali, Ebrahim Ahmed Jaber Al Hatef, Hassin Shabbab Hassin Alamri
pp. 374–384 · DOI: 10.5530/jyp.2024.16.49 · Published
Qualitative research is a method of collecting data that does not involve numbers. It is used to understand human behavior, attitudes, beliefs and personality traits. It is different from quantitative research as it does…
Review
Unraveling the Enigma of Syphilis: A Comprehensive Review
Pooja Rathore, Vivek Mishra, Navneet Bansal, Ananya Sharma, Arti Saini, Inderjeet Verma
pp. 385–390 · DOI: 10.5530/jyp.2024.16.50 · Published
Treponema pallidum(T. pallidum) transmits syphilis through sexual contact or perinatal transmission. T. pallidumis widely known for being invasive and immune-evasive; its clinical symptoms are commonly mistaken for those…
Review
Animal Models: Catalysts for Advancing Topical Treatments in Rheumatoid Arthritis
Mamta Kumari, Dipti Gohil, Piyushkumar Sadhu, Chitrali Talele, Niyati Shah, Nirmal Shah
pp. 391–399 · DOI: 10.5530/jyp.2024.16.51 · Published
Rheumatoid Arthritis (RA) is a chronic autoimmune condition causing joint inflammation and damage. Despite treatment progress, effective topical therapies pose challenges. Animal models, like Collagen-Induced Arthritis (…
Review
Central Composite Design: An Optimization Tool for Developing Pharmaceutical Formulations
Sruthi Somadasan, Gopinath Subramaniyan, Meriton Stanly Athisayaraj, Satheesh Kumar Sukumaran
pp. 400–409 · DOI: 10.5530/jyp.2024.16.52 · Published
Design and optimization are pivotal in a pharmaceutical company's formulation and manufacturing process. Various approaches and methodologies are employed in formulation design. A quantitative adjustment to a component, …
Review
Exploring Transferosomes: A Comprehensive Review of Novel Strategies and Applications in Drug Delivery
Lavani Firdos, Chinthaginjala Haranath, Singareddy Yasaswini, Rompicharla Narasimha Sai, Turubilli Satish
pp. 410–415 · DOI: 10.5530/jyp.2024.16.53 · Published
A potential development in medication administration, transferosomes are lipid-based vesicles that have been designed with edge activators, especially for transdermal and transmucosal uses. Transferosomes, which are most…
Review
Magnetic Nano-Particles: Properties, Synthesis and its Application in Treatment of Breast Cancer-A Critical Review
Shobhana N, Prakash Goudanavar, Mallamma T, Butchi Raju Akondi
pp. 416–424 · DOI: 10.5530/jyp.2024.16.54 · Published
Magnetic Nanoparticles (MNPs) are now being utilized more frequently in experimental research on cancer treatments, which has become one of the most difficult problems in medical science. The fundamental objective of thi…
Review
Relationship between Vitamin D Deficiency and Hypothyroidism-A Review
Bipin Shaji, Juno Jerold Joel, Raghava Sharma
pp. 425–430 · DOI: 10.5530/jyp.2024.16.55 · Published
Vitamin D has a crucial role in maintaining thyroid and immune function. In hypothyroidism, the gland is underactive and Vitamin D impacts this condition. Vitamin D regulates gene expression in thyroid hormone synthesis …
Review
Diet-Driven Alterations in Gut Microbiota and their Implications for Cancer Therapy: A Review
Saurav Raj, Megha Hegde, Sanatkumar Bharamu Nyamagoud, Shamita Shyam Sail, Chandrashekhar Patil, Kaushal Kumar, Nikhil Bohra
pp. 431–438 · DOI: 10.5530/jyp.2024.16.56 · Published
The gut microbiome is being frequently acknowledged for its impact on intestinal and extra-intestinal conditions, notably cancer. Here, diet is the most extensively researched modulator of gut microbiota among various en…
Review
Effect of ARNI (Sacubitril/Valsartan) and SGLT2 Inhibitors (Dapagliflozin) either alone or in Combination on Heart Failure: An Exploration of Novelty
Girish B S, Joel M. Johns, C. S Meghana, R. Srinivasan
pp. 439–446 · DOI: 10.5530/jyp.2024.16.57 · Published
Cardiovascular Diseases (CVD) have claimed millions of lives, despite the efforts of medical professionals. There are several treatment methods for blocking a few neurohormonal cascades; however, it is debatable because …
Review
Drug Interactions: Mechanisms, Assessment and Management Strategies
Udigala Renukaprasad Rakshith, Salini Parameswaran Nair, Arjun Hunsur Ranganath, Praveen Halagali
pp. 447–455 · DOI: 10.5530/jyp.2024.16.58 · Published
Drug interactions represent a significant challenge in modern medicine, as the concomitant use of multiple medications is prevalent in-patient care. Understanding the mechanisms behind drug interactions, accurately asses…
Review
Unraveling the Nexus: Post-COVID Hyperglycaemia and Diabetes-A Comprehensive Review of the Intricate Interplay and Implications for Glycemic Control
Neena Elsa Varghese, Vinitha Chandrasekaran, Krishnaveni Kandasamy, Kameswaran Ramalingam
pp. 456–460 · DOI: 10.5530/jyp.2024.16.59 · Published
The global impact of Severe Acute Respiratory Syndrome Coronavirus-2 (SARSCOV2) is profound, with Coronavirus Disease 2019 (COVID-19) presenting a clinical spectrum that leads to multi-systemic failure, particularly affe…

Original Artcile

Article
Analytical Evaluation of Processed and Unprocessed Castor Oil
Anjali S. Katore, Anita Wanjari, Utkarsha Kandalkar, Harlin Swer
pp. 461–468 · DOI: 10.5530/jyp.2024.16.60 · Published
Background:Medicated oils and Clarified butter are often utilized in the Traditional System of Indian Medicine for internal and external use. To improve the durability and efficacy of therapeutic oil unique processing is…
Article
The Effectiveness of Hydroalcoholic Extract and Fraction of Cucumis melo on Amelioration of High Fat Diet Induced hepatotoxicity: A Comprehensive Approach Integrating Computational and Preclinical Validation
Sanjay R. Ugare, Nayeem A. Khatib, Faizan A. Beerwalaa, Ashwini Ratnakar, Dhanashree Patil, Vishal S. Pati, Darasaguppe R. Harish
pp. 469–479 · DOI: 10.5530/jyp.2024.16.61 · Published
Background:Non-Alcoholic Fatty Liver Disease (NAFLD) is most prevalent global health problem, develops due to accumulation lipids in the hepatocytes in the form of Triglycerides (TG) and Free Fatty Acids (FFA). Tradition…
Article
Neuroprotective Effect of Diplocyclos palmatus on Aβ (25-35) Induced Alzheimer’s Disease in Mice
Rama Manda, Narsimha Reddy Yellu
pp. 480–487 · DOI: 10.5530/jyp.2024.16.62 · Published
Objectives:Alzheimer's disease is primarily caused by neurotoxic effects of amyloid beta Aβ(25-35) peptide accumulation and increased levels of Acetylcholinesterase Enzyme (AChE). Acetylcholinesterase inhibitors report f…
Article
Evaluation of Topical Anti-Inflammatory Potential of Mentha piperita L. Extract by Formulation of Microemulgel
Kamlesh Machewar, Rajendra Kakde, Prafulla Sabale
pp. 488–497 · DOI: 10.5530/jyp.2024.16.63 · Published
Background:The present study is designed to develop a novel dosage form i.e. microemulgel which will enhance the rate of absorption in the systemic circulation and ultimately enhance the pharmacological effect of the Men…
Article
Synthesis and Biological Properties of 4-Chloro- N1-(5-Chloro-1H-Indol-1-yl)-N2-(2-Chlorophenyl) benzene-1,2-Diamine Derivatives
Nikita Shridhar Andhale, Rohit Jaysing Bhor, Mahesh Hari Kolhe, Tanishka Anil Pawar, Pornima Ramdas Tambe, Rupali Mahadev Ghule, Sarthak Anil Bhange, Bhakti Sharad Thete, Pruthviraj Vijay Kute, Pratik Vijay Malvade, Jyoti Ramkisan Bhagat, Poonam Prakash Waykar
pp. 498–505 · DOI: 10.5530/jyp.2024.16.64 · Published
Background:Five-membered heterocycle with one neighbouring nitrogen atoms is present in the indole nucleus. Heterocyclic substances feature two adjacent benzene and pyrrole ring atoms. Indole are heterocyclic compounds w…
Article
Assessing Views on Using Surplus Human Bio Specimens for Future Research among Pharmaceutical Sponsors: A Prospective Interventional Study
Kurubara Amaresh, Madiwalayya Shivakantayya Ganachari, Revanasiddappa Devarinti
pp. 506–519 · DOI: 10.5530/jyp.2024.16.65 · Published
Background:Pharmaceutical sponsors have a significant responsibility in gathering and overseeing the storage of leftover human biological samples. Understanding the proper utilization and potential risks associated with …
Article
Biotin-Functionalized Lipid Nanoparticles: A Promising Approach for Gemcitabine Delivery in Non-Small Cell Lung Cancer Treatment
Rithanya Sureshkumar, Nithyananth Muniswamy
pp. 520–534 · DOI: 10.5530/jyp.2024.16.66 · Published
Background:Gemcitabine (GEM), a Biopharmaceutical Classification System (BCS) class-III drug, holds promise for non-small cell lung cancer treatment. Utilizing lipid-based nanoparticles for targeted delivery has proven e…
Article
Fabrication and Characterization of Azadirachta indica oil Induced Nanoemulgel Using 33 Central Composite Design (CCD): Assessment of Antibacterial Activity
Koushik Yetukuri, Barakathulla Mohammad, Vimala Nookala, Nikitha Pentyala, Ujwala Kondaveeti, Shalini Palla, Vikas Madapati, Venkateswara Rao Vishnumolakala, Rama Rao Nadendla
pp. 535–546 · DOI: 10.5530/jyp.2024.16.67 · Published
Background:In this study, neemoil's therapeutic potential against bacterial inflammations is explored through nanoemulsion technology. Despite its historical significance in traditional medicine, neemoil formulations fac…
Article
Formulation Development, Optimization and Evaluation of Imipramine Loaded Nano-Structured Lipid Carrier
Rincy Roy, Veintramuthu Sankar, Pranav Ragavendra
pp. 547–555 · DOI: 10.5530/jyp.2024.16.68 · Published
Background:Nano-structure Lipid Carriers (NLCs) are small spheres extending in scale from 10 to 1000 nanometres comprised of biocompatible and biodegradable lipids. These spheres can encapsulate both hydrophilic and lipo…
Article
Examining Restless Leg Syndrome in Chronic Kidney Disease: Comprehensive Analysis
Rajesh Hadia, Harshal Joshi, Kaushik Rana, Feba Gleetas, Dhruvi Tailor, Vedant Tailor, Hemraj Singh Rajput
pp. 556–562 · DOI: 10.5530/jyp.2024.16.69 · Published
Background:Restless Leg Syndrome (RLS) is frequently associated with Chronic Kidney Disease (CKD), often under diagnosed and inadequately treated. Hence, this study aimed to ascertain the prevalence of CKD-induced RLS, e…
Article
COVID-19 Vaccination Status and Rational Use of Antibiotics in Women: A Prospective Cross-Sectional Study during the COVID-19 Pandemic in India
Swetha Soma, Manichandana Narla, Nandini Rajuri, Arundhati Sai Gaddam, Satyanarayana SV Padi
pp. 563–569 · DOI: 10.5530/jyp.2024.16.70 · Published
Background:Diverse beliefs and perceptions on the use of COVID-19 vaccines and drugs have been affecting the acceptance of COVID-19 vaccination and maternal and child health. Further, inappropriate use of antibiotics ind…
Article
Prevalence of Drug-Related Problems in Patients with Acute Heart Failure Admitted to the Intensive Critical Care Unit
Syeda Safa Afshi, Sobia Noor, Shaik Shahbaaz, Kaneez Fathima
pp. 570–577 · DOI: 10.5530/jyp.2024.16.71 · Published
Background:Drug-Related Problems (DRPs) are prevalent among patients with acute heart failure, potentially leading to adverse outcomes. Understanding the prevalence and nature of DRPs is crucial for improving patient car…
Article
Subgingival Delivery of Bifidobacterium Gel versus Tetracycline Gel as an Adjunct to Scaling and Root Planing-A Randomized Controlled Trial
Kavya Gandrakota, Shruthi Sethuraman, Nisha Krishnavilasom Jayakumari, Kaipa venkata Narasimha Vidyadhar
pp. 578–585 · DOI: 10.5530/jyp.2024.16.72 · Published
Background:Periodontitis is a common chronic inflammatory condition in adult population affecting both the hard and soft tissues surrounding the teeth. Bacteriotherapy is an alternative way to suppress infections by usin…
Article
Assessing the Impact of Clinical Pharmacist Led Education Modality Towards Knowledge, Attitude and Practice (KAP) among Gestational Hypothyroid Patients
Gangayya J. Wakkundmath, Muriel Lacerda, Roshan Abraham Ajit,, Nida Yusuf, Geetanjali Salimath
pp. 586–593 · DOI: 10.5530/jyp.2024.16.73 · Published
Background:Hypothyroidism is the most prevalent endocrine condition among women of reproductive age, affecting 3-5% of the entire pregnant population. If left untreated, it can lead to serious maternal and fetal complica…

Case Report

Article
Ebstien Anomaly with Cardiomegaly in a Paediatric Patient: Case Report
Tahameen K kurubanavar, Bibi Khuteja Jangliwale, Arnab Sarkar, Agadi Hiremath Viswanatha Swamy, Prajnashree Acharya, Sanatkumar Bharamu Nyamagoud
pp. 594–596 · DOI: 10.5530/jyp.2024.16.74 · Published
Ebstien anomaly is a rare heart problem present at birth and has a varied clinical course, it’s a congenital heart defect of the tricuspid valve. We hereby describe a 13-year-old child, was presented with history of Ebst…
Article
Autoimmune Unraveling: Phenobarbital-Associated Pemphigus Vulgaris Case Report
Prajnashree Acharya, Sanatkumar Bharamu Nyamagoud, Amisha Netalakar, Triveni Jagadish Umarani, Neeraj Hiremath, Dayana B M, Agadi Hiremath Viswanatha Swamy
pp. 597–600 · DOI: 10.5530/jyp.2024.16.75 · Published
This case report presents the clinical scenario of a 22 years old female patient with decade long history of seizure disorder and is on chronic anti-seizure management therapy. The patient’s initial symptoms manifested a…
Article
Unanticipated Second Leg Bilateral Below Knee Amputation in a Diabetic Amputee: A Case Report
Bibi Khuteja Jangliwale, Tahameen K Kurubanavar, Arnab Sarkar, Sanatkumar Bharamu Nyamagoud, Dayana BM
pp. 601–603 · DOI: 10.5530/jyp.2024.16.76 · Published
Diabetes mellitus-related lower extremity amputation increases health burden and reduces patients' quality of life, mortality and morbidity rate in a country like India. The most common complication in DM patients is unc…
Article
Surgical Excision of Fibroadenoma in a 19-Year-Old Female: A Case Report Utilizing Circumareolar Incision
Aishwarya Rakesh, Poornachandra Somwarpet Manjunatha, Arumugam Muthukumarr
pp. 604–606 · DOI: 10.5530/jyp.2024.16.77 · Published
This case report presents the surgical management of a fibroadenoma in the left breast of a Nineteen-year-old female. The patient was exposed with the complaint of a palpable lump in her left breast, prompting further in…