Animal Models: Catalysts for Advancing Topical Treatments in Rheumatoid Arthritis
Mamta Kumari1★, Dipti Gohil1, Piyushkumar Sadhu1, Chitrali Talele1, Niyati Shah1, Nirmal Shah1★ Corresponding author
- 1Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, INDIA.
CORRESPONDENCE
Mamta Kumari
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, INDIA.
Received: 29-02-2024; Revised: 20-04-2024; Accepted: 14-05-2024.
Volume 16, Issue 3 · pp. 391–399 · PUBLISHED · DOI: 10.5530/jyp.2024.16.51
ABSTRACT
Rheumatoid Arthritis (RA) is a chronic autoimmune condition causing joint inflammation and damage. Despite treatment progress, effective topical therapies pose challenges. Animal models, like Collagen-Induced Arthritis (CIA) and Adjuvant-Induced Arthritis (AIA), mimic RA pathogenesis, aiding preclinical evaluation of topical treatments. By studying these models, experts can assess the efficacy, safety and pharmacokinetics of novel topical treatments, thereby accelerating their translation into clinical practice. Optimizing drug delivery, bioavailability and minimizing side effects are critical in formulation development. Animal studies refine parameters such as vehicle selection, drug concentration and application frequency for maximal therapeutic benefit. These models also deepen understanding of RA mechanisms, informing targeted topical therapy design against specific inflammatory mediators or immune cells. Lastly, animal models accelerate topical RA treatment development, providing vital data and mechanistic insights. Leveraging these models enhances formulation safety and efficacy, potentially improving patient outcomes.
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Kumari, M., Gohil, D., Sadhu, P., Talele, C., Shah, N., & Shah, N. (). Animal Models: Catalysts for Advancing Topical Treatments in Rheumatoid Arthritis. Journal of Young Pharmacists, 16(3), 391–399. https://doi.org/10.5530/jyp.2024.16.51