Volume 16, Issue 2

· pp. 139–373 · 28 articles

Volume: 16
Issue: 2
Published
Pages: 139–373
Articles: 28
Sections: 3
ISSN: Print - 0975-1483 | Online - 0975-1505
Journal: JYP

Review Article Original Artcile Case Report

In this issue

Review Article

Review
Pharmacology of Connexins-Still a Gap
Shravan Venkatraman, Kesavan Ramasamy
pp. 139–144 · DOI: 10.5530/jyp.2024.16.20 · Published
Between the cells are present the gap junctions which are made up of proteins named connexins. The connexin family in humans has cell-specific roles consisting of 21 members and the most studied one is connexin 43. Conne…
Review
Current Challenges in the Management of Tuberculosis
Vivek Srivastava, Ananya Verma
pp. 145–154 · DOI: 10.5530/jyp.2024.16.21 · Published
The global fight against Tuberculosis (TB) persists; grappling with approximately 10.6 million new cases in 2021, as documented in the 2022 WHO Global TB Report.1 Of concern is the escalating incidence of multidrug-resis…
Review
Unveiling the Relationship between Cannabidiol, Apo-lipoprotein and Neurological Disorders: A Comprehensive Review of Molecular Targets and Current Findings
Bharat Patel, Niyati Acharya
pp. 155–166 · DOI: 10.5530/jyp.2024.16.22 · Published
Cannabis sativa, commonly known as marijuana, has been historically used for medicinal and recreational purposes. It has been employed in the treatment of neurological conditions. Cannabidiol (CBD), the active component …
Review
Exploring Traditional and Novel Diagnostic Biomarkers for Liver Fibrosis: A Comprehensive Review
Yash Subhash Janve, Jagdish Kakadiya
pp. 167–176 · DOI: 10.5530/jyp.2024.16.23 · Published
Liver fibrosis is a widespread health issue brought on by a number of causes. A disease's early diagnosis is crucial for improved patient management. Different causes of persistent liver damage can result in hepatic fibr…
Review
Incredible Use of Omega-3 Fatty Acids: A Review on Current Use and Future Prospective
Sarfaraz Ahmad, Mohammad Daud Ali, Amani Khardali, Md. Sajid Ali, Gyas Khan, Nawazish Alam, Hilal Thaibah, Ayesha Khatun, Tarique Anwer, Md. Sarfaraz Alam
pp. 177–186 · DOI: 10.5530/jyp.2024.16.24 · Published
One of the most crucial elements of cells that affect many organisms' typical growth and function is Polyunsaturated Fatty Acids (PUFAs). In nutrition and well-being, omega-3 fatty acids, a crucial subtype of Polyunsatur…
Review
Exploring the Connection between Hypothyroidism and Polycystic Ovary Syndrome: A Comprehensive Review
Indrani Barman, Trishna Sharma, Nayan Talukdar
pp. 187–194 · DOI: 10.5530/jyp.2024.16.25 · Published
Hypothyroidism and Polycystic Ovary Syndrome (PCOS) constitute prevalent endocrine conditions that have serious effects on the health of women. Hormonal dysregulation, ovarian dysfunction, and polycystic ovarian morpholo…
Review
Green Fabrication Approach to Hydrogel Synthesis by Using Natural Polymers, their Characterization, and Applications
Muhammad Abid Mustafa, Namra Rasheed, Seerat Ansar, Qadeer Zahid, Sadia Arshad, Yousra Yousra, Samia Naz, Sana Javed, Syed Hammad Ali Shah, Sehrish Sehrish, Fatima Imran, Minahil Arif, Muhammad Zahid Iqbal
pp. 195–203 · DOI: 10.5530/jyp.2024.16.26 · Published
Background:Cross-linked networks of polymers are referred to as hydrogels because they possess the ability to retain water within the interstitial spaces of the polymer chains. The fundamental building block of life is a…
Review
Types of Sampling and Sample Size Determination in Health and Social Science Research
Mohammad Daud Ali, Ebrahim Ahmed Jaber Al Hatef
pp. 204–215 · DOI: 10.5530/jyp.2024.16.27 · Published
While determining suitable sample size and sampling is one of the most crucial factors to take into account during the planning stage of a research project, researchers sometimes encounter difficulties in this regard. In…

Original Artcile

Article
Enhanced Rhinacanthin Production in Rhinacanthus nasutus Roots Using a Hydroponics and Elicitation System
Thongtham Suksawat, Pharkphoom Panichayupakaranant
pp. 216–222 · DOI: 10.5530/jyp.2024.16.28 · Published
Background:A proficient hydroponic system for the cultivation of Rhinacanthus nasutushas been implemented with the aim of augmenting rhinacanthin production. Elicitation stands out as a viable technique for bolstering th…
Article
Phytochemical Screening, Acute Toxicity and Evaluation of in vitro Antiurolithaitic Activity of Ethanolic and Methanolic Root and Leaf Extracts of Acalypha indica Linn.
Anil Kumar, Ashish Kumar Sharma
pp. 223–228 · DOI: 10.5530/jyp.2024.16.29 · Published
Background:A plethora of novel therapeutic strategies, notably urolithiasis therapy, are currently being spoke of into traditional medicine. A particularly significant herbal remedy that is employed in indigenous medicin…
Article
Novel Antibacterial Activity and Time Kill Kinetics of Ethanolic Extract of Ipomea marginata against Select Oral Micro-organisms Causing Gingivitis-An in vitro Study
Vandana Sekizhar, Saravanakumar Ravindran, Saravanan Devarajan, Vijayan Venugopal, Raja Arun
pp. 229–235 · DOI: 10.5530/jyp.2024.16.30 · Published
Background:Leaves of the plant Ipomea marginatais commonly used in Indian folklore medicine to treat skin infections however the antibacterial property of Ipomea marginataagainst oral microorganisms causing gingivitis an…
Article
Study, Docking, in silico ADME and Predicted Acute Toxicity of Novel Hetero-Aromatic Imidazolidine Analogues as Potential Anti-Epileptic Agents
Rohit Jaysing Bhor, Mayur Sitaram Gaikwad, Omprakash Arjunrao Londhe, Tanaya Prakash Wakchaure, Sambodhi Ashokrao Patil, Prashant Suresh Ingle, Pallavi Annasaheb Sonawane
pp. 236–243 · DOI: 10.5530/jyp.2024.16.31 · Published
Background:In the present work, molecular docking analysis was conducted on proposed protein derivatives from the protein data bank using the Auto Dock for Docking programme. study on protein binding affinity using 1-ace…
Article
2,4-Substituted Oxazolones: Antioxidant Potential Exploration
Anushka Thanvi, Bharath Kumar Chagaleti, Srimathi R, Kathiravan M K, B. Shanthakumar
pp. 244–251 · DOI: 10.5530/jyp.2024.16.32 · Published
Background:This study focuses on the development of a novel and environmentally friendly synthetic methodology for the production of a series of six 4-benzylidene-2-phenyloxazol- 5(4H)-one derivative (M1-M6). The approac…
Article
Synthesis, Characterization and in vivo Biological Activity of n-(2-chlorophenyl)-2-(2-methyl-5-nitro-1h-imidazol-1-yl) Acetamide and its Derivatives
Omprakash Arjunrao Londhe, Rohit Jaysing Bhor, Prashant Suresh Ingle, Zameer Shah Mahemood Shah, Dipali Rajendra Gade, Rajshree Dadasaheb Ghogare
pp. 252–260 · DOI: 10.5530/jyp.2024.16.33 · Published
Background:A heterocyclic hydrocarbon with distinct fundamental structural features in its molecular structure is imidazole. In Generalized seizure, patient brain has abnormal electrical activity on both sides of the bra…
Article
Simultaneous Determination of Gallic Acid, Berberine and Trigonelline in Polyherbal Churna by HPTLC Method
Sneha Patil, Pinky Khushwah, Sachin Gudasi, Mrityunjaya Patil, Mahantesh Kunchanur, Rahul Koli
pp. 261–268 · DOI: 10.5530/jyp.2024.16.34 · Published
Background:Ayurvedic medicines have a lot of potential because of their comprehensive approach to illness care, yet there is a need for sufficient standardization before they can be used in mainstream medicine. Neverthel…
Article
Stability-Indicating HPTLC Method for Concurrent Estimation of Triacontane and Beta-Sitosterol in Ailanthus excelsa Roxb.: A DoE Approach
Sachin Gudasi, Kalpana Patil, Ashwini Chougla, Priya Shetti
pp. 269–279 · DOI: 10.5530/jyp.2024.16.35 · Published
Background:Triacontane and beta-sitosterol, though promising in various applications, face challenges due to low solubility and susceptibility to photosensitivity. Enhancing their effectiveness requires overcoming these …
Article
Exploring an Industrial Manufacturing Process of a Drug Containing Tenofovir
María de los Ángeles Peña, Torrado Guillermo, Torres Norma Sofía, Peña-Fernández Antonio, Martínez-Alonso Borja, Gallego Bárbara
pp. 280–291 · DOI: 10.5530/jyp.2024.16.36 · Published
Background:Tenofovir is an antiretroviral drug, a reverse transcriptase inhibitor formulated as tenofovir disoproxil in its saline form, which acts as a prodrug of tenofovir. Its clinical use is indicated in the treatmen…
Article
Development, Validation, and Psychometric Analysis of a Patient Information Leaflet for Heart Failure with Reduced Ejection Fraction
Anu Philip, Chakrakodi Sasidhara Shastry, Basavaraj Utagi
pp. 292–300 · DOI: 10.5530/jyp.2024.16.37 · Published
Background:A Patient Information Leaflet (PIL) is a widely accepted counselling aid to educate patients. The current study aimed to prepare and validate an easy-to-understand PIL explicitly tailored for patients with Hea…
Article
Clinical Evaluation of T-AYU-HM Premium in Sickle Cell Disease (HbSS) Patients: A Retrospective Study
Atul M Desai, Desai Kavita A, Desai Hemshree, Desai Rutvij A, Desai Chirag K
pp. 301–307 · DOI: 10.5530/jyp.2024.16.38 · Published
Background:Sickle cell disease (HbSS) is one of the main hemoglobinopathies that affect the indigenous tribes and is a significant cause of morbidity and mortality. The effectiveness and safety of alternative medicines f…
Article
Serum Fructosamine and Glycosylated Haemoglobin in Diabetic Subjects and their Non-Diabetic First-Degree Relatives
Aarti Sati, Amit Varma, Neeraj Kumar, Tariq Masood, Milan Prabhakar
pp. 308–314 · DOI: 10.5530/jyp.2024.16.39 · Published
Aim:To Assess Serum fructosamine and glycosylated haemoglobin in diabetic subjects and their non-diabetic first-degree relatives, a comparative evaluation. Background:Glycosylated Hemoglobin has been used for decades for…
Article
Teneligliptin as an Adjuvant Therapy in Type 2 Diabetic Management: A Prospective Observational Study
Menaka Kaliyan, Prabha Thangavel, Senthilkumar Palaniappan
pp. 315–321 · DOI: 10.5530/jyp.2024.16.40 · Published
Background:Diabetes Mellitus (DM) is a metabolic disorder with hyperglycemia. Management of diabetes is a global health challenge. The goal of this research was designed to prospectively analyze the safety of Teneliglipt…
Article
Assessment of Adverse Drug Reactions in Treating Common Mental Health Disorders-Findings from a Tertiary Care Teaching Hospital in Puducherry
Arya Jayasree, Padmavathi Shanmuganathan, Parthasarathy Ramamurthy, Alwar Mandayam Cumara
pp. 322–327 · DOI: 10.5530/jyp.2024.16.41 · Published
Background:As per National Institute for Health and Care Excellence (NICE) guidelines, depression and anxiety are common mental health disorders. Antidepressants are used in the treatment of these disorders. It is well a…
Article
Optimizing Oral Anticoagulation Therapy: Impact of Pharmacists Intervention in Patient Knowledge and International Normalized Ratio (INR) Control
Ancy Thomas, Ajilan Haleel Ruby, Shubham Mendgule, Anushree Deshpande, Suresh Patted, Aishwarya Hiremath, Ramesh Bhandari
pp. 328–333 · DOI: 10.5530/jyp.2024.16.42 · Published
Background:Oral Anticoagulant is a therapy indicated for thromboembolic disorders, which requires close observation of the international normalized ratio and patient education for better therapeutic outcomes. Management …
Article
Assessment of Self-Medication Practices and Associated Factors by Clinical Pharmacists in a Rural Population of Arunachal Pradesh, India
Barun Ranjan Sarkar, Anand Mahalwar
pp. 334–340 · DOI: 10.5530/jyp.2024.16.43 · Published
Background:Self-medication is a major concern for health authorities worldwide. The main objective of this study was to determine the prevalence of Self-medication and its associated factors in a rural community of India…
Article
Assessment of Knowledge towards Alzheimer’s Disease among the Community Pharmacists of North Karnataka: A Survey Based Cross-Sectional Observational Study
Abhishek Basappa Jayappa, Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Viswanatha Swamy, Shivani Sheeli, Srujana Kattishetti
pp. 341–345 · DOI: 10.5530/jyp.2024.16.44 · Published
Background:Alzheimer’s disease is a leading cause of dementia in the world which is characterized by progressive cognitive decline. The increasing number of cases of Alzheimer’s disease has increased the necessity of hea…
Article
Assessment of Knowledge of Oral Hygiene Practices during Pandemic and its Post-COVID-19 Impact: A Survey-Based Study
Falak Chawla, Areeba Arif, Pooja Jain, Nuzhat Banu, Ayaz Ahmed, Mohammad Daud Ali, Mohd. Aamir Mirza, Zeenat Iqbal
pp. 346–354 · DOI: 10.5530/jyp.2024.16.45 · Published
Objectives:The main objective of the study was to assess Knowledge of oral hygiene practices during the pandemic and its post-COVID-19 impact among the community of Delhi and NCR region. Materials and Methods:A cross-sec…
Article
Assessing Knowledge and Practice of Self-Administration of Insulin among Diabetes Mellitus Patients: Implications for Enhanced Diabetes Care
Piyushkumar Sadhu, Falguni Rathod, Mamta Kumari, Hemraj Singh Rajput
pp. 362–368 · DOI: 10.5530/jyp.2024.16.47 · Published
Background:Type II diabetes mellitus poses substantial management challenges, and self-administered insulin management is crucial in diabetes care. Nonetheless, numerous patients encounter difficulties in insulin adminis…

Case Report

Article
Evans Syndrome: A Case Study with Substantial Comparison of Literature Review
Aishwarya Loliyekar, Manjula Gudhoor, Madiwalayya Shivakantayya Ganachari, Abhilasha Sampagar
pp. 369–373 · DOI: 10.5530/jyp.2024.16.48 · Published
Evans syndrome is an autoimmune disease characterized by the presence of two or more cytopenias, most commonly Immune Thrombocytopenia (ITP) and Autoimmune Hemolytic Anemia (AIHA), regardless of immune neutropenia. Evans…