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Journal of Young PharmacistsNOW IN
Review

Potential of Medicinal Plants to Ameliorate Retinopathy Events in Diabetes: A Systematic Review

Phaik Har Yong1, Shirley Ling Zin Yii1, Meram Azzani2★, Deepa Anbazhagan3, Zhi Xiang Ng4★ Corresponding author

  1. 1School of Bioscience, Faculty of Pharmacy and Biomedical Sciences, MAHSA University, Selangor, MALAYSIA.
  2. 2Department of Public Health Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Sungai Buloh, Selangor, MALAYSIA.
  3. 3Department of Microbiology, International Medical School (IMS), Management and Science University (MSU), Shah Alam, Selangor, MALAYSIA.
  4. 4School of Biosciences, Faculty of Science and Engineering, University of Nottingham Malaysia, Selangor, MALAYSIA.

CORRESPONDENCE

Meram Azzani

Department of Public Health Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Sungai Buloh, Selangor, MALAYSIA.

meram@uitm.edu.my

Received: 06-02-2024; Revised: 29-05-2024; Accepted: 11-06-2024.

Volume 16, Issue 4 · pp. 633–641 · PUBLISHED · DOI: 10.5530/jyp.2024.16.81

View on JYP original site ↗

ABSTRACT

Diabetic Retinopathy (DR) is one of the most common diabetic complications which can lead to vision loss if left unattended. Medicinal plants are considered as a treatment option for its lesser side effects. Given the overwhelming number of studies on various medicinal plants using different subjects, this systematic review aims to update the current status of the potential of medicinal plants in ameliorating DR. Literature from the years 2011 to 2020 was retrieved from PubMed, ScienceDirect and Scopus databases using the search terms: Medicinal plants AND (diabetes OR hyper glycaemia) AND retinopathy. The PRISMA guidelines were adhered to for reporting the systematic review, while the SYRCLE tool was used to assess the risk of bias in animal studies. Inclusion and exclusion criteria were established for selecting compatible studies. Based on these criteria, four out of 439 studies were selected: Studies on DR in rats included three or more assays for measuring retinal vascular permeability, VEGF protein and gene expressions and body weight. An additional six studies from a manual search brought the total to ten selected studies. All studied medicinal plants demonstrated potential in ameliorating DR, based on their downregulation of diabetes-induced retinal vascular leakage and VEGF expressions. Medicinal plants with significant potential in attenuating DR included Zingiber zerumbetrhizomes and its active ingredient, zerumbone; Lycium barbarum; Plantaginis semen; and apocynin. The aqueous extracts of Radix astragali, Radix angelica sinensis, Panax notoginseng, Lycopus lucidusTurcz and total lignans from Fructus arctiican be further evaluated in future studies.

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    Yong, P. H., Yii, S. L. Z., Azzani, M., Anbazhagan, D., & Ng, Z. X. (). Potential of Medicinal Plants to Ameliorate Retinopathy Events in Diabetes: A Systematic Review. Journal of Young Pharmacists, 16(4), 633–641. https://doi.org/DOI: 10.5530/jyp.2024.16.81