Darier Disease: A Case Report with Psychiatric Involvement
Anusha Rao1, Shristi Reddy1, Prasannakumar C Bullapur1, Shamita Shyam Sail1, Sanatkumar Bharamu Nyamagoud1, Agadi Hiremath Viswanatha Swamy1
- 1Department of Pharmacy Practice, KLE College of Pharmacy (A Constituent Unit of KLE Academy of Higher Education and Research, Belagavi), Vidyanagar, Hubballi, Karnataka, INDIA.
CORRESPONDENCE
Received: 01-03-2024; Revised: 03-04-2024; Accepted: 21-07-2024.
Volume 16, Issue 4 · pp. 861–864 · PUBLISHED 2026 · DOI: 10.5530/jyp.2024.16.110
ABSTRACT
This case report outlines the clinical presentation and management of a 35-year-old female diagnosed with Darier disease, a rare autosomal dominant disorder resulting from an ATP2A2 gene mutation. The patient's atypical disease course, featuring facial involvement and a history of psychosis and depression with characteristic features, such as hyperkeratotic papules and nail changes, were noted was managed with a three-month isotretinoin regimen and concurrent antipsychotic therapy for coexisting depression and psychosis. This case highlights the need for a comprehensive, multidisciplinary approach to address both dermatological and psychiatric aspects in the management of Darier disease. The coexistence of psychiatric conditions in the form of depression and psychosis adds complexity to the clinical picture. This case emphasizes the importance of considering these factors in the diagnosis and treatment of Darier disease.
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Rao, A., Reddy, S., Bullapur, P. C., Sail, S. S., Nyamagoud, S. B., & Swamy, A. H. V. (2026). Darier Disease: A Case Report with Psychiatric Involvement. Journal of Young Pharmacists, 16(4), 861–864. https://doi.org/10.5530/jyp.2024.16.110