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Antibacterial and Antifungal Activities of Mercury Based Traditional Siddha Herbo-Metallic Formulation Mega Sanjeevi Mathirai against Selected Urogenital Pathogens

Siva Annamalai1★, Jayaveeran Thavaseelan2, Deepa Ravichandran3, Sathya Rathish Mohana Jeevanath4, Suresh Ramasamy2, Elamathi Srinivasan5, Anbarasan Balasubramaniyan6★ Corresponding author

  1. 1Department of Clinical Research, Siddha Regional Research Institute (Central Council for Research in Siddha, Ministry of Ayush, Government of India), Kuyavarpalayam, Puducherry, INDIA.
  2. 2Department of Gunapadam (Siddha Pharmacology), National Institute of Siddha, Tambaram Sanatorium, Chennai, Tamil Nadu, INDIA.
  3. 3Department of Clinical, Siddha Medical Practitioner, Sri Puttur Hospital, Tirupattur, Tamil Nadu, INDIA.
  4. 4Department of Nanju Maruthuvam (Siddha Toxicology), National Institute of Siddha, Tambaram Sanatorium, Chennai, Tamil Nadu, INDIA.
  5. 5Department of Clinical, Siddha Medical Practitioner, Malar Siddha Clinic, Dharmapuri, Tamil Nadu, INDIA.
  6. 6Department of Maruthuvam (Siddha General Medicine), National Institute of Siddha, Tambaram Sanatorium, Chennai, Tamil Nadu, INDIA.

CORRESPONDENCE

Siva Annamalai

Department of Clinical Research, Siddha Regional Research Institute (Central Council for Research in Siddha, Ministry of Ayush, Government of India), Kuyavarpalayam, Puducherry, INDIA.

raimrtcsrri@gmail.com

Received: 08-08-2024; Revised: 20-10-2024; Accepted: 13-11-2024.

Volume 17, Issue 1 · pp. 113–122 · PUBLISHED · DOI: 10.5530/jyp.20251413

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ABSTRACT

Background:Urinary Tract Infection (UTI) is referred as an infection of any part of the genitourinary tract and is more prevalent in women due to biological predisposition. Escherichia coliis a common causative organism. Globally, there is a concerning rise in antimicrobial resistance among UTI pathogens, which poses a public health risk. Symptoms of Nīrccuṟukkuand Veṭṭai noystated in Siddha literature are clinically correlated with UTIs. Materials and Methods:This study investigates Mega Sanjeevi Mathirai (MSM), a Siddha herbo-metallic formulation, for its in vitroantibacterial and antifungal properties using Agar-Disc diffusion, Minimal Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) methods against selected urogenital pathogens. Results:Substantial inhibition zones against the bacterial strains of “S. aureus, E. faecalis, E. coli and P. aeruginosaand fungal strain of C. albicans”, with significant sensitivity of the latter to Mega Sanjeevi Mathirai. MIC and MBC values against Escherichia coliare 41.2049 μg/mL and 74.1688 μg/mL, respectively. The test drug exhibits broad-spectrum antimicrobial activity, particularly effective against Candida albicans. Conclusion:The study concludes that Mega Sanjeevi Mathiraihas the potential for reducing UTIs, especially in immunocompromised patients. Future research could focus on elucidating the precise mechanisms of action, molecular interactions, toxic responses and proteomic alterations in response to pathogens and this research extend to clinical trials for validating its efficacy in human subjects. Additionally, evaluating herbo-metallic formulations for potential repurposing as treatments for antimicrobial infections could pave the way for new therapeutic approaches and help combat drug resistance.

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    Annamalai, S., Thavaseelan, J., Ravichandran, D., Jeevanath, S. R. M., Ramasamy, S., Srinivasan, E., & Balasubramaniyan, A. (). Antibacterial and Antifungal Activities of Mercury Based Traditional Siddha Herbo-Metallic Formulation Mega Sanjeevi Mathirai against Selected Urogenital Pathogens. Journal of Young Pharmacists, 17(1), 113–122. https://doi.org/10.5530/jyp.20251413