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Article

Histopathological Variation on Testis of Sex Reassignment Surgery (SRS) Transgenders on Hormonal Therapy

Preetha Devi Naval Boopathy1, Siva Kaliyamoorthy2, Uma Arumbuliyur Natarajan1★★ Corresponding author

  1. 1Department of Medical Genetics, School of Allied Health Sciences, Sri Balaji Vidyapeeth (Deemed to Be University), Puducherry, INDIA.
  2. 2Department of Pathology, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission’s Research Foundation (Deemed to Be University), Puducherry, INDIA.

CORRESPONDENCE

Uma Arumbuliyur Natarajan

Department of Medical Genetics, School of Allied Health Sciences, Sri Balaji Vidyapeeth (Deemed to Be University), Puducherry, INDIA.

umaan@mgmcri.ac.in

Received: 28-05-2024; Revised: 18-07-2024; Accepted: 06-10-2024.

Volume 17, Issue 1 · pp. 234–238 · PUBLISHED · DOI: 10.5530/jyp.20251268

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ABSTRACT

Background:The purpose of this study was to investigate whether the histopathology of the male transsexual's testis could provide insight into the causes of male transsexualism. Hence, the present study is to planned to investigate significant tissue changes in the male transsexual's testis via histopathological analysis. Materials and Methods:Light microscopy was used to examine histological sections of testicular tissues taken during sex reassignment surgery from phenotypic male transsexuals (n=50, average age range: 39 years) with XY sex chromosomal constitution. The patients had been receiving feminizing hormone (oestrogen) therapy for two to three years when their diagnoses were made based on clinical and psychological data. Results:The fifty participants' notable histological findings included: (i) Spermatozoa with maturation arrest; (ii) Hypo-spermatozoa; (iii) Rete testis hyperplasia; (iv) Epithelial hyperplasia; (v) thicker basement membranes and tubular atrophy; and (vi) seminiferous tubules; primarily displaying sertoli cells with cytoplasmic vacuolization and maturation arrest. Conclusion:The current study, propose that refractoriness to oestrogen and the iatrogenic effects of oestrogen superimposed on normal or altered hypoathalamo-pituitary function are the causes of the observed histological characteristics.

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    Boopathy, P. D. N., Kaliyamoorthy, S., & Natarajan, U. A. (). Histopathological Variation on Testis of Sex Reassignment Surgery (SRS) Transgenders on Hormonal Therapy. Journal of Young Pharmacists, 17(1), 234–238. https://doi.org/10.5530/jyp.20251268