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Novasomes: A Versatile Drug Delivery System for Enhanced Therapeutic Efficacy

Muhammad Abid Mustafa1★, Namra Rasheed1, Maryam Ayesha1, Qurat ul Ain1, Maryam Mughal1, Muhammad Fahad1, Hamda Shakir1, Ansa Ijaz1, Muhammad Ali Tahir1, Meer Muhammad1, Moiz Ali1, Areej Kainat1★ Corresponding author

  1. 1Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, PAKISTAN.

CORRESPONDENCE

Muhammad Abid Mustafa

Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, PAKISTAN.

abidbhatti222@gmail.com

Received: 25-08-2024; Revised: 29-09-2024; Accepted: 03-11-2024.

Volume 17, Issue 1 · pp. 36–45 · PUBLISHED · DOI: 10.5530/jyp.20251440

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ABSTRACT

Novasomes, a new drug carrier developed by Novavax, offers enhanced absorption and reduced side effects compared to traditional forms. These multilayered vesicles, with a diameter of 200-700 nm, maintain stability across pH and temperature ranges. They can be positively, negatively, or neutrally charged, enhancing drug encapsulation efficiency. Novasomes are versatile pharmaceutical tools used for treating ophthalmic conditions and fungal infections, improving drug bioavailability, stability, and penetration. Their ability to encapsulate a variety of drugs makes them suitable for a wide range of therapeutic applications, showing promising results in enhancing drug efficacy and improving patient outcomes. Their unique structural properties enable controlled drug release, and their excellent safety profile, demonstrated in numerous studies, supports their potential use in pharmaceutical technology, providing reassurance to the audience. Novasome's disadvantages include the requirement for specialized equipment for production and the possibility of skin irritation. Nonetheless, they are a good choice for several medicinal applications due to their advantages in improving drug delivery. Characterization techniques include FTIR, permeation studies, DSC, zeta potential measurement, drug release, vivo studies, and stability studies. Innovative drug delivery systems, such as Novasomes, have shown promising results in improving drug efficacy and patient outcomes. They reduce systemic side effects by targeting the affected area and lowering drug dosages, minimizing potential adverse reactions. Future studies can concentrate on examining how novasome technology might be used to deliver a greater variety of drugs and vaccines, as well as creating more effective and efficient processes for developing novasome vesicles.

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    Mustafa, M. A., Rasheed, N., Ayesha, M., Ain, Q. U., Mughal, M., Fahad, M., Shakir, H., Ijaz, A., Tahir, M. A., Muhammad, M., Ali, M., & Kainat, A. (). Novasomes: A Versatile Drug Delivery System for Enhanced Therapeutic Efficacy. Journal of Young Pharmacists, 17(1), 36–45. https://doi.org/10.5530/jyp.20251440