Volume 18, Issue 1

Ashish Kumar Nirmal, Ashish Singhai, Mukesh Singh Sikarwar

pp. 1–16 · DOI: 10.5530/jyp.20260196 · 2026

Diabetes mellitus is a chronic metabolic disorder characterised by the inability to mobilise the glucose in proper way, which severely retards the healing process of the wound. Chronic hyperglycaemia causes vascular dysf…

V Jenanee, S. Nithya, V Hemapriya, P. K Anamika, M Mubeen, S Sindhu, G Divya Neelaambari, Sanjana Sajeevan, M Jithendra

pp. 17–22 · DOI: 10.5530/jyp.20250140 · 2026

Cancer is still one of the leading causes of death worldwide because of adverse effects and inadequate tumor clearance. Oncolytic Viruses (OVs) offer a new and promising approach by selectively infecting and destroying c…

Harjot Singh, Felix Tan Yee Shuen, Sherly Deborah George

pp. 23–27 · DOI: 10.5530/jyp.20260302 · 2026

Trigonelline is a pyridine alkaloid abundant in fenugreek and coffee that has attracted growing interest for its potential cardiometabolic relevance. This narrative review summarizes mechanistic pathways and available ev…

Pandian Paneer Selvam, Usha Kumari, Kueh Chia Shin, Lim Jing Han, Xun Zhen, Mohamed Asem Ameerdin, Nishan Ansari, Subramani Parasuraman

pp. 28–38 · DOI: 10.5530/jyp.20260314 · 2026

Hesperidin is a naturally occurring citrus bioflavonoid that has gained significant interest for its wide range of pharmacological and therapeutic activities. Found abundantly in citrus fruits, hesperidin exhibits potent…

Yaga Maheswar Reddy, Chinthaginjala Haranath, Dasari Bhargavi, Gogula Priya, Subramanyam Nikhila, Uppara Sruthi, Tadipatri Shaik Tasleem, Kamisetty Veekshana

pp. 39–45 · DOI: 10.5530/jyp.20260297 · 2026

Fruit fly, or Drosophila melanogaster, is becoming a cornerstone model organism for biomedical research as a result of its genetic tractability, affordability, and high conservation of genetic pathways with humans. Droso…

Harshini Mandala, Vidyavathi Maruvajala, Krishana Tejaswi Achanta

pp. 46–57 · DOI: 10.5530/jyp.20260261 · 2026

Skin tissue engineering seeks to fabricate neo-tissue and enhance the integration of host tissue for usage in regenerative medicine. In most cases, biocompatible polymers and growth factors induce tissues in the surround…

Pradeep Kumar, Vaibhav Rastogi

pp. 58–63 · DOI: 10.5530/jyp.20260223 · 2026

Background Moisture induced degradation significantly influences the physicochemical stability of pharmaceutical formulations leading to reduced potency, and therapeutic efficacy. Objectives This study methodologically e…

Sree Janardhanan Vaithiyanathan, Rashmi Devanga Ramesh

pp. 64–69 · DOI: 10.5530/jyp.20250384 · 2026

The rising clinical usage of fixed-dose combination drugs including Metformin and Sodium-Glucose Cotransporter-2 (SGLT2) inhibitors, in particular Dapagliflozin, has necessitated the development of reliable, sensitive, a…

Jeetendra Kumar Gupta, Priyanga Jaganath, Ramenani Hari Babu, Konatham Teja Kumar Reddy, Venkata Lakshamana Sagar Dantinapalli, Selvaraja Elumalai, Thota Chandrasekhar Yadav, Venkateswara Rao Rachumallu, Prabakaran Sankar, Jaya Shree Srinivasan, Lokeshvar Ravikumar

pp. 70–79 · DOI: 10.5530/jyp.20260170 · 2026

Graphene-based electrochemical biosensors are emerging as powerful diagnostic platforms for early, non-invasive detection of oral cancer. This review critically evaluates recent advances in graphene-enabled salivary bios…

Thenraja Sankar, Deephiha Elango, Mohamed Jafran Jamal Farook, Mohamed Imrankhan Kameed Kattuva, Kamaladevi Manivannan, P S N Meeran, Tasneem Fathima Mohamed, Karthika Selvaraj, V Kalaiselvi

pp. 80–85 · DOI: 10.5530/jyp.20260253 · 2026

By keeping medication concentrations within a specific therapeutic window, Therapeutic Medication Monitoring (TDM), a crucial part of precision medicine, guarantees the best possible therapeutic results. It is essential …

Diptimayee Jena, Asra Jabeen, Swetha Vegesna, Gowri Sankar Chintapalli, Vikash Dash, Debasis Patra, Kirtimaya Mishra

pp. 86–91 · DOI: 10.5530/jyp.20261657 · 2026

Drug delivery systems are an important part of modern medicine, which aims for maximizing therapeutic efficacy, reduce adverse effects, and increase patient compliance. An important development in this area is the use of…

Niraj Pandit, Varsha Mahavarakar, Sandeep Narwane, Palak Agrawal, Anup Kharde, Deepak Phalke, Rahul Kunkulol

pp. 92–96 · DOI: 10.5530/jyp.20250320 · 2026

Background Pharmacovigilance plays a crucial role in safeguarding public health by detecting, assessing, and preventing Adverse Drug Reactions (ADRs) and related drug problems. Despite the establishment of the Pharmacovi…

Chandana Ganesha, Mohammad Ali, Bharathi Doddla Raghunathanaidu

pp. 97–107 · DOI: 10.5530/jyp.20260098 · 2026

Background Diabetic Nephropathy (DN) is a major complication of diabetes characterized by oxidative stress and inflammation, leading to progressive renal damage. This study aimed to investigate the reno-protective effect…

Pravin Kumar Muthukumaresan, Sujatha Kuppusamy, Sneha Raja, Narmatha Rajarathinam, Lakshana Kolanji, Jayasutha Jayram, Christian Gnanaraj Johnson, Manickavasagam Meenakshisundaram

pp. 108–113 · DOI: 10.5530/jyp.20250204 · 2026

Background Cisplatin is a commonly used chemotherapeutic agent whose clinical utility is limited by dose-related toxicities. The present study aimed to assess the incidence and clinical impact of cisplatin-induced toxici…

Basavaraj Dinnimath, Rohan Singadi, Soumya Biradar, Priyanka Naik, Sunil Doddamani

pp. 114–126 · DOI: 10.5530/jyp.20260124 · 2026

Background Antimicrobial agents occupy a significant importance today due to the increasing challenge posed by microbial resistance to existing drugs. Azo dyes, time tested compounds, known for their antimicrobial effica…

Asish Sahu, Anjan Kumar Mahapatra, Rajeshree Panigrahi, Prasanta Kumar Choudhury, Ajit Nahak

pp. 127–135 · DOI: 10.5530/jyp.20250271 · 2026

Objectives The current research is aimed to design and development of a Floating Drug Delivery System (FDDS) for tramadol HCl by enhancing the gastric residence time and by releasing the drug at the targeted site. Materi…

Sengamalam Ravindran, Vijayan Venugopal, Anbazhagan Sockalingam

pp. 136–142 · DOI: 10.5530/jyp.20260319 · 2026

Background Pulmonary infections need specific strategies which facilitate drug delivery more directly to the lungs and avert systemic toxicity. However, Remdesivir is an antiviral that is found to be potent but has poor …

Mohamed Fathalla Zayed, Amany Mohamed Jouda, Aaeshah Jameel Aljwania, Sedra Hassan Mohamed, Tala Ali Naffa, Amani Ezeldin Mahran, Rifan Aqeel Suwaydi, Aymen Ali Alqurain, Moudi Mubarak Alasmari

pp. 143–149 · DOI: 10.5530/jyp.20260405 · 2026

Background Sodium-Glucose Cotransporter-2 (SGLT-2) inhibitors are modern antidiabetic agents that work by preventing the kidneys from reabsorbing glucose, reducing Blood Glucose (BG) levels, and causing glucose to leave …

Rajesh Hadia, Anuvarsh Nair, Alan Sabu, Varunsingh Saggu, Cyril Sajan, Hemraj Singh Rajput, Manish Rasania

pp. 150–156 · DOI: 10.5530/jyp.20260123 · 2026

Background Neonatal septicemia is a major cause of neonatal mortality, often affecting infants from the first day of life. Given the underdeveloped neonatal immune system, antibiotics must be prescribed judiciously. Time…

Anushree Shrikant Deshpande, Madiwalayya Shivakantayya Ganachari

pp. 157–163 · DOI: 10.5530/jyp.20250042 · 2026

Background Diabetes Mellitus (DM) is a growing global concern, with women in India facing high prevalence and poor medication adherence, which hinders glycemic control and increases complication risk. Objectives To evalu…